scholarly journals Virology, Pathogenetic Mechanisms, and Associated Diseases of Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)

2002 ◽  
Vol 77 (9) ◽  
pp. 941-949 ◽  
Author(s):  
Ronit Sarid ◽  
Avraham Klepfish ◽  
Ami Schattner
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Pathogenetic Mechanisms ◽  
Associated Diseases

Changes in the Immune Responses Against Human Herpesvirus-8 in the Disease Course of Posttransplant Kaposi Sarcoma

2008 ◽  
Vol 86 (5) ◽  
pp. 738-744 ◽  
Author(s):  
Patrizia Barozzi ◽  
Chiara Bonini ◽  
Leonardo Potenza ◽  
Michele Masetti ◽  
Gianni Cappelli ◽  
...  
Keyword(s):  
Immune Responses ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Disease Course ◽  
Herpesvirus 8

Presence of Human Herpesvirus 8 DNA Sequences in Renal Transplantation-Associated Pleural Kaposi Sarcoma

1999 ◽  
Vol 123 (12) ◽  
pp. 1269-1273
Author(s):  
J. Javier Gómez-Román ◽  
J. Gonzalo Ocejo-Vinyals ◽  
Pablo Sánchez-Velasco ◽  
Francisco Leyva-Cobián ◽  
J. Fernando Val-Bernal
Keyword(s):  
Kidney Transplantation ◽  
Pleural Effusion ◽  
Dna Sequences ◽  
Blot Hybridization ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Southern Blot Hybridization ◽  
Pulmonary Involvement ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8

Abstract Objective.—To describe one case of symptomatic skin and pleural Kaposi sarcoma (KS) associated with kidney transplantation. Diagnosis was supported by morphologic study and human herpesvirus 8 (HHV-8) detection in both tissues. Pulmonary involvement was not present. Design.—The presence of HHV-8 DNA sequences was proved using polymerase chain reaction (PCR), Southern blot hybridization, and in situ hybridization. Setting.—Human herpesvirus 8 is found in most KS from patients with and without the acquired immunodeficiency syndrome. Clinically significant pulmonary infiltration by KS is diagnosed uncommonly antemortem, and pleural disease is exceptional. Patient.—A 49-year-old man who had renal transplant with immunosuppressive therapy (tacrolimus and prednisone) and developed a cutaneous KS. A pleural effusion appeared without pulmonary involvement. Both lesions disappeared when immunosuppressive drugs were suspended. Later, the pleural effusion and the cutaneous lesions reappeared. Pleural biopsy specimens showed KS infiltration. Outcome.—The patient refused treatment and was lost to follow-up. Results.—The skin and pleural biopsies showed a proliferation of spindle-shaped cells positive for CD34. The HHV-8 sequences were detected by nested PCR. No amplification was detected in uninvolved skin from the patient or in peripheral blood mononuclear cells from 10 healthy individuals used as controls. The Southern blot hybridization confirmed these results. Conclusions.—To our knowledge, this is the first report of HHV-8 in symptomatic pleural KS, which was probably associated with immunosuppression after kidney transplantation. The demonstration of HHV-8 DNA in biopsy material in the appropriate cells could be diagnostic when the morphologic setting is consistent with KS.

scholarly journals Human Herpesvirus-8 Infection Associated with Kaposi Sarcoma, Multicentric Castleman's Disease, and Plasmablastic Microlymphoma in a Man with AIDS: A Case Report with Review of Pathophysiologic Processes

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Christian Eaton ◽  
Russell Dorer ◽  
David M. Aboulafia
Keyword(s):  
Lymph Node ◽  
Highly Active Antiretroviral Therapy ◽  
Castleman’S Disease ◽  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Castleman's Disease ◽  
Multicentric Castleman’S Disease ◽  
Herpesvirus 8 ◽  
Multicentric Castleman's Disease

Kaposi sarcoma (KS), multicentric Castleman's disease (MCD), and plasmablastic microlymphoma, are all linked to human herpesvirus-8 (HHV-8) infection and HIV-induced immunodeficiency. Herein, we describe the case of a Kenyan man diagnosed with HIV in 2000. He deferred highly active antiretroviral therapy (HAART) and remained in good health until his CD4+ count declined in 2006. He was hospitalized with bacterial pneumonia in 2008, after which he agreed to take HAART but did so sporadically. In 2010, he was hospitalized with fever, lymphadenopathy, pancytopenia, and an elevated HHV-8 viral load. A lymph node biopsy showed findings consistent with KS, MCD, and plasmablastic microlymphoma. Eight months after starting liposomal doxorubicin, Rituximab, and a new HAART regimen, he has improved clinically, and his HIV and HHV-8 viral loads are suppressed. These three conditions, found in the same lymph node, underscore the inflammatory and malignant potential of HHV-8, particularly in the milieu of HIV-induced immunodeficiency.

scholarly journals Human Herpesvirus 8 in Italian HIV-Seronegative Patients With Kaposi Sarcoma

1998 ◽  
Vol 134 (6) ◽  
Author(s):  
Paola Cattani ◽  
Maria Capuano ◽  
Ilaria Lesnoni La Parola ◽  
Roberto Guido ◽  
Rosaria Santangelo ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8

Absence of Kaposi Sarcoma Among Ethiopian Immigrants to Israel Despite High Seroprevalence of Human Herpesvirus 8

2002 ◽  
Vol 77 (9) ◽  
pp. 905-909 ◽  
Author(s):  
Zehava Grossman ◽  
Jose Iscovich ◽  
Fidi Schwartz ◽  
Esther Azizi ◽  
Avraham Klepfish ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
High Seroprevalence ◽  
Herpesvirus 8 ◽  
Ethiopian Immigrants

scholarly journals A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1997 ◽  
Vol 94 (2) ◽  
pp. 690-694 ◽  
Author(s):  
E. H.- Y. Cheng ◽  
J. Nicholas ◽  
D. S. Bellows ◽  
G. S. Hayward ◽  
H.-G. Guo ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Kaposi Sarcoma ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8
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