Allergic Contact Dermatitis Due to Topical Application of Corticosteroids: Review and Clinical Implications

1997 ◽  
Vol 72 (12) ◽  
pp. 1141-1144 ◽  
Author(s):  
Michael E. Lutz ◽  
Rokea A. El-Azhary
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Topical Application ◽  
Clinical Implications ◽  
Allergic Contact

scholarly journals Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mao-Qiang Man ◽  
Melanie Hupe ◽  
Richard Sun ◽  
George Man ◽  
Theodora M. Mauro ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Stratum Corneum ◽  
Allergic Contact Dermatitis ◽  
Topical Application ◽  
Therapeutic Effects ◽  
Irritant Contact Dermatitis ◽  
Murine Models ◽  
Cutaneous Inflammation ◽  
Allergic Contact ◽  
Topical Applications

Herbal medicines have been used in preventing and treating skin disorders for centuries. It has been demonstrated that systemic administration of chrysanthemum extract exhibits anti-inflammatory properties. However, whether topical applications of apigenin, a constituent of chrysanthemum extract, influence cutaneous inflammation is still unclear. In the present study, we first tested whether topical applications of apigenin alleviate cutaneous inflammation in murine models of acute dermatitis. The murine models of acute allergic contact dermatitis and acute irritant contact dermatitis were established by topical application of oxazolone and phorbol 12-myristate 13-acetate (TPA), respectively. Inflammation was assessed in both dermatitis models by measuring ear thickness. Additionally, the effect of apigenin on stratum corneum function in a murine subacute allergic contact dermatitis model was assessed with an MPA5 physiology monitor. Our results demonstrate that topical applications of apigenin exhibit therapeutic effects in both acute irritant contact dermatitis and allergic contact dermatitis models. Moreover, in comparison with the vehicle treatment, topical apigenin treatment significantly reduced transepidermal water loss, lowered skin surface pH, and increased stratum corneum hydration in a subacute murine allergic contact dermatitis model. Together, these results suggest that topical application of apigenin could provide an alternative regimen for the treatment of dermatitis.

scholarly journals Allergic Contact Dermatitis and Autoeczematization to Proctosedyl® Cream and Proctomyxin® Cream

2018 ◽  
Vol 10 (3) ◽  
pp. 238-246 ◽  
Author(s):  
J.D. Matthew Hughes ◽  
Melanie D. Pratt
Keyword(s):  
Contact Dermatitis ◽  
Patient Education ◽  
Topical Corticosteroid ◽  
Allergic Contact Dermatitis ◽  
Topical Application ◽  
Perianal Region ◽  
Allergic Contact

Proctosedyl® and Proctomyxin® are two commonly prescribed hemorrhoid therapies. Their topical application to the perianal region may be complicated by a local allergic contact dermatitis and subsequent autoeczematization reaction. We present three cases of an autoeczematization (ID) reaction to varying topical allergens found in Proctosedyl®/Proctomyxin®. It is our recommendation that physician and patient education, avoidance of allergens (or cross-reactants), and appropriate choice of topical corticosteroid is important in preventing and avoiding flares.

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