scholarly journals Differential Pulse Voltammetric Determination of Fulvestrant in Pharmaceutical Dosage Forms and Serum Samples

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Dilek Kul ◽  
Burcu Doğan-Topal ◽  
Sibel A. Özkan ◽  
Bengi Uslu
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Oxidation Mechanism ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Serum Samples ◽  
Standard Samples ◽  
Pharmaceutical Dosage Forms ◽  
Diffusion Controlled

The electrooxidation behavior and determination of fulvestrant at a glassy carbon electrode were investigated. The voltammetric study of the model compounds allowed elucidating the possible oxidation mechanism of fulvestrant. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate was determined. The oxidation of fulvestrant showed a single and irreversible peak at glassy carbon electrode, and the process was found diffusion controlled. Linear responses were obtained for the concentrations between4×10−6M and6×10−5M in standard samples and between2×10−5M and1×10−4M in serum samples. The repeatability of the method was found 0.93 RSD%. The repeatability, reproducibility, precision, and accuracy of proposed method were investigated.

Electrochemical studies of ascorbic acid, dopamine, and uric acid at a dl-norvaline-deposited glassy carbon electrode

2014 ◽  
Vol 92 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Mahmoud Mohamed Kamel ◽  
Ehab Mahmoud Abdalla ◽  
Mohamed Sayed Ibrahim ◽  
Yassin Mohamed Temerk
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Solution Ph

The electrochemical behavior of ascorbic acid (AA), dopamine (DA), and uric acid (UA) on a dl-norvaline-modified glassy carbon electrode (GCE) was studied by cyclic voltammetry. The bare GCE failed to distinguish the oxidation peaks of AA, DA, and UA in phosphate-buffered solution (pH 5.0), while the dl-norvaline-modified GCE could separate them efficiently. In differential pulse voltammetric (DPV) measurements, the modified electrode resolved the overlapped voltammetric responses of AA, DA, and UA into three well-defined voltammetric peaks. Under optimum conditions, the anodic peak currents of DPV for AA, DA, and UA were proportional to the concentration in the range of 20–400, 1–40, and 15–180 μmol/L, respectively, with a correlation coefficient (r) of around 0.998. The detection limits were 5, 0.3, and 10 μmol/L (S/N = 3) for AA, DA, and UA, respectively. Satisfactory results were achieved for the determination of AA in vitamin C tablets, DA in a dopamine ampoule sample, and UA in human blood serum samples.

scholarly journals ELECTROCHEMICAL DETERMINATION OF KETOROLAC - A NON-OPIOID ANALGESIC AT GLASSY CARBON ELECTRODE

2019 ◽  
pp. 199-204
Author(s):  
ROHINI M HANABARATTI ◽  
JAYANT I GOWDA ◽  
SURESH M TUWAR
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Low Cost ◽  
Opioid Analgesic ◽  
Oxidation Mechanism ◽  
Differential Pulse ◽  
Electrochemical Determination ◽  
Carbon Electrode ◽  
Peak Current

Objectives: The study has been carried to investigate the electro-oxidation mechanism and to develop a selective and sensitive method for determination of ketorolac (KTL), a non-opioid analgesic drug,.Methods: A simple electro analytical method was used for the determination of ketorolac (KTL) using glassy carbon electrode by cyclic and differential pulse voltammetric techniques (DPV). The effect of various experimental parameters such as accumulation time, pH, scan rate, on the voltammetric responses of KTL was evaluated.Results: In the optimized conditions, variation of peak current with respect to concentration was studied and the calibration curve of the peak current vs. KTL concentration was drawn with a linear range of 10- 350 μM with an excellent detection limit of 8.08×10-8 M. This method was successfully tested for the determination of KTL in pharmaceuticals and human urine samples.Conclusion: From the results, it was observed that, the selected method is rapid, sensitive and low cost.

Differential pulse voltammetric determination of fenobucarb at the glassy carbon electrode, after its alkaline hydrolysis to a phenolic product

1997 ◽  
Vol 9 (12) ◽  
pp. 952-955 ◽  
Author(s):  
Agustina Guiberteau Cabanillas ◽  
Teresa Galeano Díaz ◽  
Francisco Salinas ◽  
Juan Manuel Ortiz ◽  
Jean Michel Kauffmann
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Alkaline Hydrolysis ◽  
Differential Pulse ◽  
Voltammetric Determination ◽  
Carbon Electrode

scholarly journals The effect of tamoxifen on the electrochemical behavior of Bi+3/Bi on the glassy carbon electrode and its determination via differential pulse anodic stripping voltammetry

2019 ◽  
Vol 63 (1) ◽  
Author(s):  
Mehdi Jalali ◽  
Zeinab Deris Falahieh ◽  
Mohammad Alimoradi ◽  
Jalal Albadi ◽  
Ali Niazi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Electrochemical Behavior ◽  
Electrochemical Impedance ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Peak Height ◽  
Carbon Electrode

The electrochemical behavior of Bi+3 ions on the surface of a glassy carbon electrode, in acidic media and in the presence of tamoxifen, was investigated. Cyclic voltammetry, chronoamperometry, differential pulse voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy with energy-dispersive X-ray spectroscopy were used to find the probable mechanism contributing to the reduction of the peak height of bismuth oxidation with an increase in the concentration of tamoxifen. The obtained results show a slight interaction between the bismuth species and tamoxifen which co-deposit on the surface of glassy carbon electrode. Therefore, the reduction in the peak height of bismuth oxidation as a function of tamoxifen concentration was used to develop a new differential pulse anodic striping voltammetry method for determination of trace amount of tamoxifen. The effects of experimental parameters on the in situ DPASV of Bi+3 ions in the presence of tamoxifen shown the optimal conditions as: 2 mol L-1 H2SO4 (1% v v-1 MeOH), a deposition potential of -0.5 V, a deposition time of 60 s, and a glassy carbon electrode rotation rate of 300 rpm. The calibration curve was plotted in the range of 0.5 to 6 µg mL-1 and the limits of detection and quantitation were calculated to be 3.1 × 10-5 µg mL-1 and 1.0 × 10-4 µg mL-1, respectively. The mean, RSD, and relative bias for 0.5 µg mL-1 (n=5) were found to be 0.49 µg mL-1, 0.3%, and 2%, respectively. Finally, the proposed method was successfully used for the determination of tamoxifen in serum and pharmaceutical samples.

Sign in / Sign up

Export Citation Format

Share Document