scholarly journals Free Thyroxine Level in the High Normal Reference Range Prescribed for Nonpregnant Women May Reduce the Preterm Delivery Rate in Multiparous

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
P. Torremante ◽  
F. Flock ◽  
W. Kirschner
Keyword(s):  
Serum Level ◽  
Preterm Delivery ◽  
Reference Range ◽  
Free Thyroxine ◽  
Delivery Rate ◽  
Control Group ◽  
Normal Reference Range ◽  
Autoimmune Antibodies ◽  
Normal Reference ◽  
Thyroxine Replacement

Preterm birth is the most common reason for perinatal morbidity and mortality in the western world. It has been shown that in euthyreotic pregnant women with thyroid autoimmune antibodies, L-Thyroxine replacement reduces preterm delivery rate in singleton pregnancies. We investigated in a nonrandomized retrospective observational study whether L-Thyroxine replacement, maintaining maternal free thyroxine serum level in the high normal reference range prescribed for nonpregnant women also influences the rate of preterm delivery in women without thyroid autoimmune antibodies. As control group for preterm delivery rate, data from perinatal statistics of the State of Baden-Württemberg from 2006 were used. The preterm delivery rate in the study group was significantly reduced. The subgroup analysis shows no difference in primiparous but a decline in multiparous by approximately 61% with L-Thyroxine replacement. Maintaining free thyroxine serum level in the high normal reference range prescribed for nonpregnant women may reduce the preterm delivery rate.

Free thyroxine within the normal reference range predicts risk of atrial fibrillation

2019 ◽  
Vol 31 (1) ◽  
pp. 18-29
Author(s):  
Jeffrey L. Anderson ◽  
Victoria Jacobs ◽  
Heidi T. May ◽  
Tami L. Bair ◽  
Barry A. Benowitz ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Reference Range ◽  
Free Thyroxine ◽  
Normal Reference Range ◽  
Normal Reference

scholarly journals Subclinical Hypothyroidism During Valproic Acid Therapy in Children with Epilepsy

2019 ◽  
Vol 17 (2) ◽  
pp. 14-20
Author(s):  
Dhananjoy Das ◽  
Meah Monjur Ahmed ◽  
Pranab Kumar Chowdhury ◽  
Pradip Kumar Dutta ◽  
MA Chowwdhury
Keyword(s):  
Valproic Acid ◽  
Subclinical Hypothyroidism ◽  
Reference Range ◽  
Control Group ◽  
Base Line ◽  
Normal Reference Range ◽  
Normal Reference ◽  
Epileptic Children ◽  
The Mean

Background : Valproic Acid (VPA) is an effective anticonvulsant widely used for the treatment of epilepsy in children, but there are pitfalls in VPA therapy, especially in case of various endocrine organs like thyroid. So the aim of this study was to evaluate the thyroid dysfunction in terms of subclinical hypothyroidism during Valproic Acid (VPA) therapy in children with epilepsy. Methods: The study was conducted in the Department of Paediatrics, and Shishu Bikas Kendra, Chittagong Medical College Hospital (CMCH) over one year duration on 50 newly diagnosed idiopathic epileptic children who were decided to start Valproate at the dose of 20mg/kg/day. At the same time similar number (n=50) of age and sex matched children visited the paediatric OPD for other health events(e.g. acute upper respiratory infection, Influenza like illness and Acute watery diarrhoea) other than epilepsy were included in the study as control group. Thyroid function status like serum levels of Thyroid-Stimulating Hormone (TSH) Free Triiodothyronine (FT3) and Free Thyroxin (FT4) were evaluated at baseline and after six months. Moreover, serum VPA level was also measured in children receiving valproate at follow up visit. Anti thyroid peroxidise antibody (Anti TPO ab) was checked at follow up visit in those having TSH level beyond normal reference range. After collecting all data it was analyzed by SPSS-19. Results: In the current study, cases consisted of 30(60%) male and 20(40%) female children. Male to female ratio was 1.5:1. Gender and age were matched in cases and control group (p>0.05). Most of the population in the cases were from rural areas 29(58%) and most of them 40(80%) belonged to middle class family. The mean±SD of TSH level significantly increased after six months in comparison with base line values (1.76±0.57μIU/ml vs. 2.70±1.50μIU/ml, p<0.05) and with control group at follow up visit (1.74±0.73μIU/ml vs 2.70±1.50μIU, p<0.05). On the other hand, in the control group there were no significant changes of TSH level in comparison with base line (1.82±0.55μIU vs 1.74±0.73μIU/ml, p=0.16). The mean±SD of FT4 value decreased significantly in the cases after six months though remained within normal reference range (1.24±0.27ng/dl vs1.11±0.13ng/dl, p<0.05) FT3 level remained unchanged. Five (10%) epileptic children in the cases were found to have subclinical hypothyroidism at follow up who had TSH level beyond the normal reference range. Anti thyroid peroxidase antibody was negative among them. In contrast, no one in control group was found to have TSH level beyond the normal limit. All cases were clinically euthyroid. No significant correlations were found between TSH level and serum VPA level (r2 = 0.035 p= 0.193). Conclusion: Subclinical hypothyroidism develops in children with epilepsy during VPA therapy. Proper attention should be given so that development of overt hypothyroidism can be avoided. Chatt Maa Shi Hosp Med Coll J; Vol.17 (2); Jul 2018; Page 14-20

Evaluation of normal reference range for thyroid uptake of technetium-99 m in a single centre UK population

2017 ◽  
Author(s):  
Mavin Macauley ◽  
Mohamed Shagwi ◽  
Kim Howe ◽  
Andrew Curry ◽  
Elizabeth Howell ◽  
...  
Keyword(s):  
Reference Range ◽  
Single Centre ◽  
Normal Reference Range ◽  
Normal Reference ◽  
Thyroid Uptake

scholarly journals The Short Cosyntropin Test Revisited: New Normal Reference Range Using LC-MS/MS

2018 ◽  
Vol 103 (4) ◽  
pp. 1696-1703 ◽  
Author(s):  
Grethe Å Ueland ◽  
Paal Methlie ◽  
Marianne Øksnes ◽  
Hrafnkell B Thordarson ◽  
Jørn Sagen ◽  
...  
Keyword(s):  
Reference Range ◽  
Normal Reference Range ◽  
New Normal ◽  
Normal Reference

scholarly journals EP08.08: Ventricular occupying ratio at 18-30 weeks' gestation: normal reference range and ventriculomegaly

2018 ◽  
Vol 52 ◽  
pp. 224-224
Author(s):  
R.K. Pooh ◽  
T. Nakamura ◽  
M. Machida ◽  
K. Uenishi ◽  
K. Kusunoki ◽  
...  
Keyword(s):  
Reference Range ◽  
Normal Reference Range ◽  
Normal Reference

Assessing the haematology and serum chemistry of Uda rams fed different Kanwa based mineral licks

2021 ◽  
Vol 6 (6) ◽  
pp. 209-215
Author(s):  
A. Abdulkarim ◽  
◽  
K. M. Aljameel ◽  
Keyword(s):  
Reference Range ◽  
Health Hazard ◽  
Serum Biochemistry ◽  
Serum Chemistry ◽  
Normal Range ◽  
Blood Profile ◽  
Normal Reference Range ◽  
Normal Reference ◽  
Mineral Licks ◽  
Sheep Production

This study was conducted at the Department of Animal Science’s Teaching and Research farm of Usmanu Danfodiyo University, Sokoto to evaluate the effect of feeding different kanwa based mineral licks on blood profile of Uda rams. Blood of twenty (20) yearlings Uda rams aged by dentition were used to evaluate the effect of Kanwa¬-based mineral blocks. Four (4) animals were allotted to each treatment (Kanwa block) with each animal serving as a replicate. The Kanwa used were Kanwan Bai-Bai, Kanwan Kolo, Hogga, Balma and conventional mineral lick to represent treatment 1, 2, 3, 4 and 5 respectively. Data was collected at the end of the experiment. The result of haematological analysis showed significant (p<0.05) differences in all the parameters analysed except PCV, MCH, WBC and eosinophil; the result indicated that all the values where within the normal reference range except in MCHC where animals placed in T2 and T3 shows values slightly above the normal range. The result of serum biochemistry showed that all the values measured were within the normal reference range for sheep except the albumin of animals placed in T3 which had values slightly above the normal range. The serum mineral composition showed that Potassium levels were higher in T2 and lower in T4; however, there was no difference between animals placed in treatments 1, 2 and 3, so also between treatments 1, 3 and 4. The study concluded that Kanwa positively affected sheep production with no adverse effect on both haematological and serum chemistry, hence little health hazard is associated with feeding Kanwa-based blocks on growing Uda rams.

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