scholarly journals Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Matthew J. Crawford ◽  
Srinivas Rapireddy ◽  
Raman Bahal ◽  
Iulia Sacui ◽  
Danith H. Ly
Keyword(s):  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Side Chains ◽  
Spectroscopic Techniques ◽  
Sterically Hindered ◽  
Steric Constraint

Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations and hybridization properties of PNAs were determined using a combination of CD and UV-Vis spectroscopic techniques. Our results show that the γ-position can accommodate varying degrees of sterically hindered side-chains, reaffirming the bimodal function of PNAs as the true hybrids of “peptides” and “nucleic acids.”

scholarly journals Peptide nucleic acids and their structural modifications.

1999 ◽  
Vol 46 (3) ◽  
pp. 509-529 ◽  
Author(s):  
B Falkiewicz
Keyword(s):  
Amino Acid ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Potential Usefulness ◽  
Side Chains ◽  
Type I ◽  
Type Ii ◽  
Amino Acid Residues ◽  
Structural Modifications

Peptide (polyamide) analogues of nucleic acids (PNAs) make very promising groups of natural nucleic acid (NA) ligands and show many other interesting properties. Two types of these analogues may be highlighted as particularly interesting: the first, containing a polyamide with alternating peptide/pseudopeptide bonds as its backbone, consisting of N-(aminoalkyl)amino-acid units (type I), with nucleobases attached to the backbone nitrogen with the carboxyalkyl linker; and the second, containing a backbone consisting of amino-acid residues carrying the nucleobases in their side chains (type II). So far, these two groups have been studied most intensively. The paper describes main groups of peptide nucleic acids, as well as various other amino acid-derived nucleobase monomers or their oligomers, which were either studied in order to determine their hybridisation to nucleic acids, or only discussed with respect to their potential usefulness in the oligomerisation and nucleic acids binding.

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

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