scholarly journals Zinc Supplementation againstEimeria acervulina-Induced Oxidative Damage in Broiler Chickens

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Nedyalka V. Georgieva ◽  
Margarita Gabrashanska ◽  
Ventsislav Koinarski ◽  
Zvezdelina Yaneva
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Oxidative Damage ◽  
Broiler Chickens ◽  
Antioxidant Status ◽  
Zinc Supplementation ◽  
Eimeria Acervulina ◽  
Cu And Zn

This study was undertaken to determine the dietary supplements of Zn containing diet on the antioxidant status in chickens experimentally infected withEimeria acervulina. The antioxidant status was monitored via determination of MDA concentrations and erythrocyte SOD and CAT activities, as well as vitamin E, vitamin C, Cu, and Zn in liver, muscle, and serum. The results showed increased MDA (), CAT (), and decreased SOD () in the infected birds. Significant changes in Cu and Zn concentrations and dramatically reduction of vitamin C and E concentrations in the infected chickens were found. The observed deviations in the studied enzymes and nonenzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of chickens, infected withEimeria acervulina. Our results proved the ameliorating role of CuZn(OH)3Cl (0.170 g per kg food) againstEimeria acervulina-induced oxidative damage in infected chickens.

Role of antioxidant supplementation in oxidant/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers

2019 ◽  
Vol 16 (4) ◽  
Author(s):  
Amal Saad-Hussein ◽  
Gehan Moubarz ◽  
Sh. Abdalla Mohgah ◽  
Gh. Shousha Wafaa ◽  
H. Mohamed Aya
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Aflatoxin B1 ◽  
Antioxidant Status ◽  
Liver Enzymes ◽  
P53 Protein ◽  
Oral Supplementation ◽  
Group I ◽  
Ameliorative Effect

Abstract Background Aflatoxin B1 (AFB1) is classified as a Group I carcinogen. A Previous study found that oxidative stress from the metabolism of AFB1 induced hepatotoxic effects in wheat miller workers. Zinc and vitamin C may play a significant role in the activation of detoxification and overcoming the oxidative stress of AFB1. Objectives A prospective clinical trial was designed to evaluate the role of zinc and vitamin C oral supplementation on the oxidant-antioxidant status and the hepatotoxic effects of AFB1 in wheat miller workers. Methods Liver enzymes (ALT, AST, ALP, and GGT), P53 protein, malondialdehyde (MDA), glutathione S transferase (GST), Superoxide dismutase (SOD), zinc and vitamin C were estimated in 35 wheat miller workers before and after zinc and vitamin C supplementation for 1 month. Results The results revealed that zinc and vitamin C were significantly increased after the one-month supplementation, while liver enzymes (AST, ALP, and GGT), MDA, and GST of the workers were significantly decreased. SOD and P53 were also decreased but not to a significant level; SOD was decreased in 56% and P53 was decreased in 58% of the total workers. Conclusions Zinc and vitamin C oral supplementation for 1 month had an ameliorative effect on the hepatotoxicity of AFB1 in wheat miller workers, through decreasing MDA, SOD, and GST levels that in turn led to an improvement in their liver enzymes. Further study on a larger scale is needed to confirm these results.

Multigenerational selection towards longevity changes the protective role of vitamin C against graphene oxide-induced oxidative stress in house crickets

2021 ◽  
pp. 117996
Author(s):  
Barbara Flasz ◽  
Marta Dziewięcka ◽  
Andrzej Kędziorski ◽  
Monika Tarnawska ◽  
Jan Augustyniak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Vitamin C ◽  
Protective Role

scholarly journals Effects of Caloric Restriction on Cardiac Oxidative Stress and Mitochondrial Bioenergetics: Potential Role of Cardiac Sirtuins

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Ken Shinmura
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Oxidative Damage ◽  
Caloric Restriction ◽  
Functional Decline ◽  
Cellular Damage ◽  
Free Radical Theory ◽  
Radical Theory ◽  
Stress Theory

The biology of aging has not been fully clarified, but the free radical theory of aging is one of the strongest aging theories proposed to date. The free radical theory has been expanded to the oxidative stress theory, in which mitochondria play a central role in the development of the aging process because of their critical roles in bioenergetics, oxidant production, and regulation of cell death. A decline in cardiac mitochondrial function associated with the accumulation of oxidative damage might be responsible, at least in part, for the decline in cardiac performance with age. In contrast, lifelong caloric restriction can attenuate functional decline with age, delay the onset of morbidity, and extend lifespan in various species. The effect of caloric restriction appears to be related to a reduction in cellular damage induced by reactive oxygen species. There is increasing evidence that sirtuins play an essential role in the reduction of mitochondrial oxidative stress during caloric restriction. We speculate that cardiac sirtuins attenuate the accumulation of oxidative damage associated with age by modifying specific mitochondrial proteins posttranscriptionally. Therefore, the distinct role of each sirtuin in the heart subjected to caloric restriction should be clarified to translate sirtuin biology into clinical practice.

scholarly journals The Role Of Dietary Zinc Restriction On Antioxidant Status And Oxidative Stress

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Richard S Bruno ◽  
Yang Song ◽  
Scott W Leonard ◽  
Alan W Taylor ◽  
Maret G Traber ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Dietary Zinc ◽  
And Oxidative Stress

Role of Vitamins in Neurodegenerative Diseases: A Review

2021 ◽  
Vol 20 ◽  
Author(s):  
Ravi Ranjan Kumar ◽  
Lovekesh Singh ◽  
Amandeep Thakur ◽  
Shamsher Singh ◽  
Bhupinder Kumar
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Vitamin D ◽  
Vitamin C ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Vitamin D Deficiency ◽  
Neurological Disorders ◽  
The Brain

Background: Vitamins are the micronutrients required for boosting the immune system and managing any future infection. Vitamins are involved in neurogenesis, a defense mechanism working in neurons, metabolic reactions, neuronal survival, and neuronal transmission. Their deficiency leads to abnormal functions in the brain like oxidative stress, mitochondrial dysfunction, accumulation of proteins (synuclein, Aβ plaques), neurodegeneration, and excitotoxicity. Methods: In this review, we have compiled various reports collected from PubMed, Scholar Google, Research gate, and Science direct. The findings were evaluated, compiled, and represented in this manuscript. Conclusion: The deficiency of vitamins in the body causes various neurological disorders like Alzheimer’s disease, Parkinson’s disease, Huntington's disease, and depression. We have discussed the role of vitamins in neurological disorders and the normal human body. Depression is linked to a deficiency of vitamin-C and vitamin B. In the case of Alzheimer’s disease, there is a lack of vitamin-B1, B12, and vitamin-A, which results in Aβ-plaques. Similarly, in Parkinson’s disease, vitamin-D deficiency leads to a decrease in the level of dopamine, and imbalance in vitamin D leads to accumulation of synuclein. In MS, Vitamin-C and Vitamin-D deficiency causes demyelination of neurons. In Huntington's disease, vitamin- C deficiency decreases the antioxidant level, enhances oxidative stress, and disrupts the glucose cycle. Vitamin B5 deficiency in Huntington's disease disrupts the synthesis of acetylcholine and hormones in the brain.

Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver

2018 ◽  
Vol 106 ◽  
pp. 232-238 ◽  
Author(s):  
Marija D. Milošević ◽  
Milica G. Paunović ◽  
Miloš M. Matić ◽  
Branka I. Ognjanović ◽  
Zorica S. Saičić
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Rat Liver
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