scholarly journals Associations between Ambulatory Blood Pressure Parameters and Cerebral White Matter Lesions

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Cristina Sierra
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
White Matter Lesions ◽  
The Elderly ◽  
Organ Damage ◽  
Common Finding ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

Silent cerebral white matter lesions (WMLs) are a common finding on magnetic resonance imaging of the brain in the elderly. However, in patients with hypertension, WMLs tend to occur earlier in life and appear to be more severe. There is a body of evidence that supports the idea that WMLs in asymptomatic hypertensive patients should be considered a silent early marker of brain damage. It is known that ambulatory blood pressure monitoring (ABPM) correlates more closely with hypertension-related organ damage than office blood pressure. This paper focuses on the associations between blood pressure parameters obtained by 24-hour ABMP and cerebral WMLs.

Cerebral white matter lesions and hypertension status in the elderly Korean: the Ansan Study

2005 ◽  
Vol 40 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Min Kyu Park ◽  
Inho Jo ◽  
Moon Ho Park ◽  
Taik Kun Kim ◽  
Sangmee Ahn Jo ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
The Elderly ◽  
Cerebral White Matter ◽  
Hypertension Status ◽  
Cerebral White Matter Lesions

scholarly journals White Matter Lesions and Cognitive Impairment as Silent Cerebral Disease in Hypertension

2006 ◽  
Vol 6 ◽  
pp. 494-501 ◽  
Author(s):  
Cristina Sierra ◽  
Antonio Coca
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
White Matter ◽  
Indirect Evidence ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cognitive Changes ◽  
Cerebral Disease ◽  
Functional Changes ◽  
Cerebral White Matter Lesions

Although the pathogenesis and clinical significance of cerebral white matter lesions remain controversial, it is well established that age and hypertension are the most important factors related to the presence of these lesions. Hypertension is known to be the most important factor for developing stroke and vascular dementia. In addition, the presence of cerebral white matter lesions is an important prognostic factor for the development of stroke, and also for cognitive impairment and dementia. The mechanisms underlying hypertension-related cognitive changes are complex and are not yet fully understood. Correlations between cerebral white matter lesions and elevated blood pressure provide indirect evidence that structural and functional changes in the brain over time may lead to lowered cognitive functioning when blood pressure control is poor or lacking.Some authors have suggested that the presence of white matter lesions in hypertensive patients could be considered an early marker of brain damage.

A follow-up study of blood pressure and cerebral white matter lesions

1999 ◽  
Vol 46 (6) ◽  
pp. 827-833 ◽  
Author(s):  
Frank-Erik De Leeuw ◽  
Jan Cees De Groot ◽  
Matthijs Oudkerk ◽  
Jacqueline C. M. Witteman ◽  
Albert Hofman ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Follow Up Study ◽  
Cerebral White Matter Lesions

scholarly journals Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions

JAMA ◽  
2019 ◽  
Vol 322 (6) ◽  
pp. 524 ◽  
Author(s):  
◽  
Ilya M. Nasrallah ◽  
Nicholas M. Pajewski ◽  
Alexander P. Auchus ◽  
Gordon Chelune ◽  
...  
Keyword(s):  
Blood Pressure ◽  
White Matter ◽  
Blood Pressure Control ◽  
White Matter Lesions ◽  
Pressure Control ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

scholarly journals Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Cristina Sierra ◽  
Alfons López-Soto ◽  
Antonio Coca
Keyword(s):  
Risk Factor ◽  
White Matter ◽  
Brain Damage ◽  
White Matter Lesions ◽  
Organ Damage ◽  
Left Ventricular ◽  
Cerebral White Matter ◽  
Chronic Hypertension ◽  
Cerebral White Matter Lesions ◽  
The Brain

Chronic hypertension leads to concomitant remodeling of the cardiac and vascular systems and various organs, especially the brain, kidney, and retina. The brain is an early target of organ damage due to high blood pressure, which is the major modifiable risk factor for stroke and small vessel disease. Stroke is the second leading cause of death and the number one cause of disability worldwide and over 80% of strokes occur in the elderly. Preclinical hypertensive lesions in most target organs are clearly identified: left ventricular hypertrophy for the heart, microalbuminuria for the kidney, fundus abnormalities for the eye, and intima-media thickness and pulse wave velocity for the vessels. However, early hypertensive brain damage is not fully studied due to difficulties in access and the expense of techniques. After age, hypertension is the most-important risk factor for cerebral white matter lesions, which are an important prognostic factor for stroke, cognitive impairment, dementia, and death. Studies have shown an association between white matter lesions and a number of extracranial systems affected by high BP and also suggest that correct antihypertensive treatment could slow white matter lesions progression. There is strong evidence that cerebral white matter lesions in hypertensive patients should be considered a silent early marker of brain damage.

scholarly journals White Matter Lesions in Adults – a Differential Diagnostic Approach

2020 ◽  
Vol 192 (12) ◽  
pp. 1154-1173 ◽  
Author(s):  
Stefan Weidauer ◽  
Marlies Wagner ◽  
Elke Hattingen
Keyword(s):  
Image Analysis ◽  
White Matter ◽  
White Matter Lesions ◽  
Common Finding ◽  
Cerebral White Matter ◽  
Neoplastic Disease ◽  
Laboratory Findings ◽  
Cerebral White Matter Lesions ◽  
Characteristic Imaging ◽  
The One

Objective Cerebral white matter lesions on MRI in adults are a common finding. On the one hand, they may correspond to a clinically incidental feature, be physiologically or age-associated, or on the other hand they may be the overture to a severe neurological disease. With regard to pathophysiological aspects, practical hints for the differential diagnostic interpretation of lesions in daily clinical practice are presented. Material and Methods With special regard to the vascular architecture and supply of the cerebral white matter, physiological structures are schematically represented and pathophysiological processes are highlighted by comparative image analysis of equally angulated MR sequences. Results The most frequent vascular, inflammatory, metabolic, and neoplastic disease entities are presented on the basis of characteristic imaging findings and corresponding clinical- neurological constellations. The details of signal intensities and localization essential for differential diagnosis are highlighted. Conclusion By means of comparative image analysis and the recognition of characteristic lesion patterns, taking into account anatomical principles and pathophysiological processes, the differential diagnostic classification of cerebral white matter lesions and associated diseases can be significantly facilitated. The additional consideration of clinical and laboratory findings is essential. Key Points:  Citation Format

Increased adiponectin is associated with cerebral white matter lesions in the elderly with cognitive impairment

2018 ◽  
Vol 33 (4) ◽  
pp. 1385-1388 ◽  
Author(s):  
Youshi Fujita ◽  
Takashi Toyomoto ◽  
Tomomi Sakoh-Goshima ◽  
Yutaka Kohno ◽  
Masafumi Okada ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
The Elderly ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions
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