scholarly journals Prostatic Adenocarcinoma Metastatic to Pleomorphic Liposarcoma, a “Collision Phenomenon”: Report of a Case with Review of Pelvic Collision Tumors

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
Somak Roy ◽  
Ronald L. Hrebinko ◽  
Kathleen M. Cieply ◽  
Anil V. Parwani ◽  
Uma N. M. Rao
Keyword(s):  
Pelvic Mass ◽  
Collision Tumor ◽  
The Body ◽  
Pathological Examination ◽  
Prior History ◽  
Pelvic Cavity ◽  
Collision Tumors ◽  
History Of ◽  
Conclusive Diagnosis

“Collision tumor” is an uncommon phenomenon characterized by coexistence of two completely distinct and independent tumors at the same site. Collision tumors have been reported in different sites in the body; however, these are particularly uncommon in the pelvic cavity. A 70-year-old man, with prior history of urothelial and prostate cancer, presented with a large pelvic mass detected on imaging studies. Pathological examination revealed a large liposarcoma with prostatic carcinoma embedded in it. Immunohistochemistry and florescence in situ hybridization studies were performed to reach to a conclusive diagnosis. To the best of our knowledge, this is the second case reported till date. We present the challenges encountered in the diagnosis of this case and review of pelvic collision tumors.

Pleomorphic lobular carcinoma in situ: A distinct entity of controversial significance.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 177-177
Author(s):  
Marina De Brot ◽  
Shirin Muhsen ◽  
Victor P. Andrade ◽  
Starr Koslow Mautner ◽  
Melissa Murray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Previous History ◽  
Prior History ◽  
Lobular Carcinoma In Situ ◽  
Pleomorphic Lobular Carcinoma ◽  
History Of

177 Background: Pleomorphic lobular carcinoma in situ (PLCIS) is an increasingly diagnosed variant of lobular carcinoma in situ. Histologically, it resembles ductal carcinoma in situ (DCIS), leading to controversy over proper management. Yet, the natural history of PLCIS is unknown. Here we describe our experience with PLCIS. Methods: Review of pathology reports (1995–2012) identified 233 cases of LCIS variants. Patients with synchronous ipsilateral DCIS or invasive cancer (IC) were excluded leaving 25 cases for review. Consensus review by 3 pathologists further excluded 7; leaving 18 cases, 12 of which were classified as PLCIS and 6 as LCIS with pleomorphic features (LCIS-PF). (Table) PLCIS was defined by cellular dyshesion, nuclear pleomorphism with a 2-3 fold size variation, conspicuous nucleoli, mitoses and abundant cytoplasm; lesions not meeting all parameters were classified as LCIS-PF. Loss of e-cadherin was confirmed; clinical data were obtained from medical records. Results: Mean patient age at diagnosis of PLCIS/LCIS-PF was 57 yrs (42-67 yrs). All cases presented with imaging abnormalities. A previous history of breast cancer was present in 7/18 (39%) pts (3/7, ipsilateral; 4/7, contralateral). Following PLCIS/LCIS-PF diagnosis, 6/18 (33%) pts underwent mastectomy and 12/18 had excision alone, with (n=3) or without chemoprevention (n=9). Margin status was negative in 4/12 pts; close in 3/12 pts and positive in 5/12 pts undergoing excision. At a median follow-up of 27 mos (2-148 mos), 2/12 pts treated with excision developed ipsilateral breast cancer (1 DCIS; 1 IC). Both had close margins at initial excision; median time to cancer, 54 mos. Conclusions: Pure PLCIS is an uncommon lesion. Synchronous malignancy or prior history of breast cancer are often present in patients with PLCIS, contributing to the difficulty in determining the actual risk conferred by this lesion and appropriate management. Efforts to systematically characterize LCIS variants and prospective documentation of outcomes are needed to clarify the significance of these lesions. [Table: see text]

Crystal-Storing Histiocytosis as a Cause of Symptomatic Cardiac Mass

2009 ◽  
Vol 133 (11) ◽  
pp. 1861-1864 ◽  
Author(s):  
Charles J. Sailey ◽  
Borislav A. Alexiev ◽  
James S. Gammie ◽  
Paula Pinell-Salles ◽  
J. Lawrence Stafford ◽  
...  
Keyword(s):  
Monoclonal Gammopathy ◽  
Plasma Cells ◽  
Periodic Acid ◽  
Right Atrial ◽  
Prior History ◽  
Low Grade ◽  
Periodic Acid Schiff ◽  
Right Atrial Mass ◽  
History Of

Abstract Crystal-storing histiocytosis is a rare disorder that is typically associated with low-grade B-cell lymphomas and monoclonal gammopathy. We present a 64-year-old man with a prior history of weakness and weight loss and hematologic evaluation that had revealed immunoglobulin G κ monoclonal light chains in the serum and negative bone marrow biopsy. He presented with supraventricular tachyarrhythmia and a right atrial mass seen on echocardiogram and excised surgically. Histologically, the tumor was composed of sheets of macrophages infiltrating the atrial myocardium. The histiocytes were filled with multiple needle-shaped, periodic acid-Schiff–negative crystals. These cells and associated plasma cells failed to show clonal light chain restriction by in situ hybridization or immunohistochemistry, and there was no area of lymphoma in the tumor. Ultrastructural examination showed numerous sticklike, trapezoidal, or polygonal dense crystals in the cytoplasm of histiocytes corroborating the diagnosis of crystal-storing histiocytosis. Although rare, crystal-storing histiocytosis should be included in the differential diagnosis of heart masses in patients with hematologic conditions associated with monoclonal gammopathy.

Pleomorphic xanthoastrocytoma and oligodendroglioma: collision of 2 morphologically and genetically distinct anaplastic components

2011 ◽  
Vol 114 (6) ◽  
pp. 1648-1653 ◽  
Author(s):  
Eyas M. Hattab ◽  
Sarah E. Martin ◽  
Scott A. Shapiro ◽  
Liang Cheng
Keyword(s):  
Collision Tumor ◽  
Genetic Alterations ◽  
Pleomorphic Xanthoastrocytoma ◽  
Molecular Signature ◽  
Pathological Examination ◽  
Glial Tumor ◽  
Cystic Changes ◽  
Oligodendroglial Component ◽  
History Of ◽  
Cytological Features

With the exception of oligoastrocytoma, mixed gliomas are rarely encountered, and the astrocytic component of mixed oligoastrocytoma is almost always fibrillary and diffusely infiltrative. Pleomorphic xanthoastrocytoma (PXA) has occasionally been described in conjunction with ganglioglioma, as well as in 1 case of oligodendroglioma. In this latter case, described by Perry et al., 1p/19q codeletions were not detected. The authors report on a 25-year-old woman with a combined PXA/oligodendroglioma in which concurrent 1p/19q codeletions were detected in the oligodendroglial component only. The patient presented with a 1-month history of headaches. Neuroimaging revealed a heterogeneous left temporal mass with focal enhancement, cystic changes, hemorrhage, and left-to-right midline shift. The patient underwent a craniotomy and gross-total resection. Pathological examination revealed a glial tumor composed of 2 apparently distinct components. The largest component exhibited a prominent fascicular, reticulin-rich, spindle cell arrangement admixed with areas of highly pleomorphic cells, with bizarre cytological features reminiscent of PXA. A smaller component was composed of cellular sheets and lobules of oligodendroglial cells. Both components were characterized by anaplastic features. Dual-color fluorescence in situ hybridization for 1p/19q codeletions was performed. Only the oligodendroglial component showed the combined 1p/19q deletions. This case represents the first instance in which PXA has been reported in conjunction with an oligodendroglioma exhibiting the “molecular signature” characteristic of oligodendroglial neoplasms. The different genetic alterations seen in the 2 components of this neoplasm argue in favor of a “collision tumor” rather than a mixed glioma of the same genotype.

scholarly journals Serous Cystadenoma of the Pancreas Presenting as a Third Primary Neoplasm

2003 ◽  
Vol 17 (9) ◽  
pp. 552-554 ◽  
Author(s):  
Aydın Şeref Köksal ◽  
Aysel Ülker ◽  
Mehmet Asıl ◽  
Bilge Tunç ◽  
Arda Kemal ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Previous History ◽  
Serous Cystadenoma ◽  
The Body ◽  
Pathological Examination ◽  
Cystic Neoplasms ◽  
Serous Cystadenomas ◽  
History Of ◽  
Primary Neoplasm ◽  
Other Neoplasms

Serous cystadenomas are the most common cystic neoplasms of the pancreas. They may occur solely or coexist with other neoplasms. A 10 cm mass involving the body of the pancreas was observed in the computed tomography of a 61-year-old man with a previous history of bladder and prostate carcinoma. Ultrasonography and computed tomography of the mass demonstrated multiple small cysts associated with a central calcified scar. A distal pancreatectomy was performed. Pathological examination confirmed the diagnosis of serous microcystic adenoma. This is the first report of a serous cystadenoma of the pancreas with two metachronous neoplasms. This feature should be kept in mind during the diagnosis and evaluation of patients with serous cystadenoma.

scholarly journals Granulocytic Sarcoma of the Male Breast in Acute Myeloblastic Leukemia with Concurrent Deletion of 5q and Trisomy 8

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Muhammad Rizwan ◽  
Md. Monirul Islam ◽  
Zia ur Rehman
Keyword(s):  
Myeloid Leukemia ◽  
Granulocytic Sarcoma ◽  
Clinical History ◽  
The Body ◽  
Male Breast ◽  
Prior History ◽  
Trisomy 8 ◽  
Extramedullary Tumor ◽  
History Of ◽  
Improve Patient

We describe a unique case of Granulocytic Sarcoma (GS) in a male, who presented to us with a painless right breast mass without any prior history of Leukemia. GS is an extramedullary tumor of myeloproliferative precursors and may involve multiple sites of the body, but involvement of male breast is extremely rare. In the absence of clinical history or hematological abnormality, GS may be misdiagnosed, depending on the degree of myeloid differentiation present within the tumor. Often it is misdiagnosed as lymphoma. Diagnosis is made by finding eosinophilic myelocytes, myeloperoxidase, chloroacetate esterase staining, and lysozyme immunostain. Chemotherapy regimens similar to acute myeloid leukemia are recommended to treat GS. Recognition of this rare entity is important because early, aggressive chemotherapy can induce regression of the tumor and improve patient longevity.

scholarly journals Lower weight gain after vaping cessation than after smoking quitting

2019 ◽  
pp. 253-258
Author(s):  
Ewelina Wawryk-Gawda ◽  
Michał K. Zarobkiewicz ◽  
Patrycja Chylińska-Wrzos ◽  
Barbara Jodłowska-Jędrych
Keyword(s):  
Weight Gain ◽  
Electronic Cigarettes ◽  
Mass Gain ◽  
The Body ◽  
Control Group ◽  
Prior History ◽  
History Of ◽  
Group A ◽  
Lower Weight Gain ◽  
Group B

Background. Smoking is frequently a way to control appetite and weight. The data concerning the body mass gain after quitting among the users of electronic cigarettes who have no prior history of smoking traditional cigarettes is inconsistent. Objective. In our study we have compared smoking and vaping impact on weight gain and glycaemia. Material and methods. 3 groups of rats were used. The group A was exposed to vapour and group B were exposed to smoke. Rats in the group C constituted the control group without nicotine exposition. Results. During 6 weeks of experiment weight gain of rats in the A and B groups was comparable, while animals from group C had gained signifi0cantly more. During 2 weeks after cessation of exposition to nicotine animals from group B gained more weight than rats of A and C group. Blood glucose was higher in group B than in groups A and C 24 h after last exposure to nicotine and 2 weeks after nicotine exposure cessation. Conclusion. Effects of vaping on weight increase is similar to smoking, but after vaping cassation weight gain is lower and comparable with nicotine nonusers.

Health Problems Related to Environmental Fibrous Minerals

2003 ◽  
Author(s):  
Gunnar Hillerdal
Keyword(s):  
Common Knowledge ◽  
Asbestos Exposure ◽  
Industrial Applications ◽  
The Body ◽  
Fibrous Materials ◽  
Mineral Fibers ◽  
Fibrous Minerals ◽  
Air Stream ◽  
History Of

Very early in the history of mining and with the industrial applications of asbestos, it was known that a variety of mineral fibers were hazardous to health. By the 1940s, the potential risk of lung cancer, in addition to the fibrosis disorder asbestosis, one of the pneumoconioses, was described. Within twenty years, another malignant disease, mesothelioma, cancer of the tissues that surround the lung, was ascribed to asbestos exposure. It is now common knowledge that inhalation of certain mineral fibers can cause disease (Skinner et al. 1988). Because the fibers are inhaled, the lung and surrounding tissues are the primary targets, but there may be subsequent reactions in many other parts of the body. The information on disease related to fibrous materials emanates from studies of occupational environments where the dose or exposure is likely to be high and continued over long periods of time. However, it has been increasingly realized that domestic or general environmental exposure is also possible and can pose grave dangers. For a mineral fiber to be inhalable it should be less than one micron in diameter, but the length can be 10 microns or greater because the particle can align with the air stream in the bronchi and penetrate far into the lung. The ratio between length and diameter of the fiber is critical. The most dangerous fibers are very thin (one tenth of a micron in diameter or less) with a high length-diameter ratio. Another important factor is biodurability. Typically, the dangerous fibers are not broken down at all or only very slowly, with half-lives in the body of many years. They may remain in situ throughout life and can be found at autopsy. There are many varieties of fibers in the environment today, both naturally occurring and man-made. Only a few, however, fulfill the above criteria and occur in amounts where human exposure is possible. The problem fibers are collectively known as asbestos and the fibrous zeolite, erionite. There are many other fibers (Skinner et al. 1988), but their contributions to human disease are not recognized. Asbestos is not a mineralogical but a commercial term.

Stage I seminoma: Treatment outcomes in a low-income country.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e15024-e15024
Author(s):  
Yazan Asad Abuodeh ◽  
Fadwa Abdelrahman ◽  
Ahmed Abdel-Fattah Salem ◽  
Naim Farah ◽  
Abdelatif Al-Mousa ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Developing Country ◽  
Low Income ◽  
Adjuvant Radiotherapy ◽  
Early Stage ◽  
Pathological Examination ◽  
Cancer Center ◽  
Prior History ◽  
History Of

e15024 Background: The aim of this report is to address treatment outcomes of patients with early-stage seminoma in a developing country with special reference to patients with history of surgical violation of the scrotum and the potential predictors of disease relapse. Methods: Seventy four patients with pure seminoma were treated at King Hussein Cancer Center (Amman, Jordan) between 2003 and 2010. All patients underwent orchiectomy. All but 3 patients received adjuvant radiotherapy. Patients who underwent surgical violation of the scrotum prior to referral were managed by further excision or irradiation of the scrotal scar. The follow-up ranged from 1 to 200 months (mean, 33 months). Results: At the time of follow-up; all but one patient remain alive. The 3-year relapse-free survival for the entire cohort was 95.9%. Three patients were burdened by relapse, all of whom received adjuvant irradiation following inguinal orchiectomy and initially harbored tumors larger than 4cm upon pathological examination. Median time to relapse was 14 months (range, 8-25 months). None were associated with elevated tumor markers prior to detection of relapse. All but one patient were successfully salvaged by chemotherapy. Conclusions: Our results confirm the excellent prognosis for patients with early-stage seminoma treated by orchiectomy and adjuvant radiotherapy in a developing country. Although all patients burdened by relapse demonstrated adverse pathological findings upon initial assessment, no consistent predictor of relapse was found. Scrotal scar re-excision or irradiation in patients with prior history of surgical violation of the scrotum are effective in preventing local failure.

scholarly journals A Unique Case of Testicular Compromise in a Patient with Ovotesticular Disorder of Sexual Development and a Solitary Testicle

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Ethan Vargo ◽  
Lillianne Stanitsas ◽  
Mark Memo
Keyword(s):  
Sexual Development ◽  
Ovarian Tissue ◽  
Prior History ◽  
Unique Case ◽  
The Past ◽  
Vascular Flow ◽  
Disorder Of Sexual Development ◽  
Increased Risk ◽  
History Of

Ovotesticular disorder of sexual development (OT-DSD), previously true hermaphroditism, is a condition in which one or both gonads contain testicular and ovarian tissue. A 23-year-old OT-DSD male patient presented with continuous pain in his right testicle which had been previously intermittent over the past five days. The patient had a prior history of left ovotestis removal with prosthesis placement, a right undescended testicle with aberrant anatomy, and hypospadias repair, all of which were corrected shortly after birth. A lack of blood flow to the testicle on Doppler ultrasound warranted immediate surgical intervention. Intraoperatively, an aberrant tunica vaginalis space with a compressive hematoma secondary to epididymal abscess rupture was identified as the causation for testicular compromise. Return of vascular flow to the testicle was confirmed with intraoperative Doppler after hematoma and epididymis excision, and the testicle was left in situ. It is imperative to consider epididymal etiologies with acute testicular pain, especially in a patient with a medical history that carries an increased risk for gonadal anomalies.

scholarly journals Collision Tumors of the Ovary: Dermoid Cyst with Borderline Epithelial Ovarian Tumor with Metachronous Invasive Epithelial Carcinoma of Ovary- A Case Series

JMS SKIMS ◽  
2018 ◽  
Vol 21 (1) ◽  
pp. 37-39
Author(s):  
Abdul Wahid Mir ◽  
Syed Basina Yasin ◽  
Syed Arshad ◽  
Irfan Robbani
Keyword(s):  
Dermoid Cyst ◽  
Ovarian Tumor ◽  
Case Series ◽  
Collision Tumor ◽  
The Body ◽  
Ovarian Tumors ◽  
Ovarian Malignancy ◽  
Epithelial Ovarian Tumor ◽  
Collision Tumors

Collision tumor is defined as the coexistence of two or more Histologically distinct tumors adjacent to each other in the same organ without any histological intermixing. Although collision tumors can occur in many organs in the body, its occurrence in ovary is extremely rare. In our series of two patients, dermoid cyst was co-existing with borderline epithelial ovarian tumors in one patient, which is rarest of rare variety of collision tumors reported in ovary. In another patient, there was recurrence in the form of invasive epithelial ovarian malignancy. JMS 2018;21(1):37-39

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