scholarly journals MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eleni Antzoulatos ◽  
Michael W. Jakowec ◽  
Giselle M. Petzinger ◽  
Ruth I. Wood
Keyword(s):  
Tyrosine Hydroxylase ◽  
Left Hemisphere ◽  
Dendritic Morphology ◽  
Neuronal Morphology ◽  
Medium Spiny Neurons ◽  
Protective Effects ◽  
Spine Density ◽  
Spiny Neurons ◽  
The Right ◽  
Gonadal Status

Nigrostriatal damage is increased in males relative to females. While estrogen is neuroprotective in females, less is known about potential protective effects of testosterone in males. We determined if castration enhances neuronal injury to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Castrates or sham-castrated mice were sacrificed 1 week following injection of MPTP (4×20 mg/kg) or saline (n=11-12/group). The right striatum was immunostained for tyrosine hydroxylase (TH). The left hemisphere was stained by Golgi Cox to quantify neuronal morphology in medium spiny neurons (MSNs) of the dorsolateral striatum. MPTP reduced TH, but there was no effect of castration and no interaction. For MSN dendritic morphology, MPTP decreased the highest branch order and increased spine density on 2nd-order dendrites. Castrated males had shorter 5th-order dendrites. However, there was no interaction between gonadal status and MPTP. Thus, castration and MPTP exert nonoverlapping effects on MSN morphology with castration acting on distal dendrites and MPTP acting proximally.

scholarly journals Severely Impaired Learning and Altered Neuronal Morphology in Mice Lacking NMDA Receptors in Medium Spiny Neurons

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e28168 ◽  
Author(s):  
Lisa R. Beutler ◽  
Kiara C. Eldred ◽  
Albert Quintana ◽  
C. Dirk Keene ◽  
Shannon E. Rose ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Neuronal Morphology ◽  
Medium Spiny Neurons ◽  
Spiny Neurons

Periadolescent nicotine administration produces enduring changes in dendritic morphology of medium spiny neurons from nucleus accumbens

2005 ◽  
Vol 385 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Craig G. McDonald ◽  
Vernon K. Dailey ◽  
Hadley C. Bergstrom ◽  
Tracey L. Wheeler ◽  
Amy K. Eppolito ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dendritic Morphology ◽  
Medium Spiny Neurons ◽  
Nicotine Administration ◽  
Spiny Neurons

scholarly journals Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model

2019 ◽  
Author(s):  
Julie E Anderson ◽  
Madison Trujillo ◽  
Taylor McElroy ◽  
Thomas Groves ◽  
Tyler Alexander ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Cognitive Impairments ◽  
Dendritic Morphology ◽  
Neuronal Morphology ◽  
Long Term Memory ◽  
Spine Density ◽  
Term Memory ◽  
Female Mice ◽  
Cytokine Analysis ◽  
Early Effects

Abstract Breast cancer (BC) is the most common cancer among women. Fortunately, BC survival rates have increased because the implementation of adjuvant chemotherapy leading to a growing population of survivors. However, chemotherapy-induced cognitive impairments (CICIs) affect up to 75% of BC survivors and may be driven by inflammation and oxidative stress. Chemotherapy-induced cognitive impairments can persist 20 years and hinder survivors’ quality of life. To identify early effects of CMF administration in mice, we chose to evaluate adult female mice at 2-week postchemotherapy. Mice received weekly IP administration of CMF (or saline) for 4 weeks, completed behavioral testing, and were sacrificed 2 weeks following their final CMF injection. Behavioral results indicated long-term memory (LTM) impairments postchemotherapy, but did not reveal short-term memory deficits. Dendritic morphology and spine data found increases in overall spine density within CA1 basal and CA3 basal dendrites, but no changes in DG, CA1 apical, or CA3 apical dendrites. Further analysis revealed decreases in arborization across the hippocampus (DG, CA1 apical and basal, CA3 apical and basal). These physiological changes within the hippocampus correlate with our behavioral data indicating LTM impairments following CMF administration in female mice 2-week postchemotherapy. Hippocampal cytokine analysis identified decreases in IL-1α, IL-1β, IL-3, IL-10, and TNF-α levels.

scholarly journals Striatal D2 Receptors Regulate Dendritic Morphology of Medium Spiny Neurons via Kir2 Channels

2012 ◽  
Vol 32 (7) ◽  
pp. 2398-2409 ◽  
Author(s):  
M. Cazorla ◽  
M. Shegda ◽  
B. Ramesh ◽  
N. L. Harrison ◽  
C. Kellendonk
Keyword(s):  
Dendritic Morphology ◽  
D2 Receptors ◽  
Medium Spiny Neurons ◽  
Spiny Neurons

scholarly journals Effects of Ethanol Exposure and Withdrawal on Neuronal Morphology in the Agranular Insular and Prelimbic Cortices: Relationship with Withdrawal-Related Structural Plasticity in the Nucleus Accumbens

2019 ◽  
Vol 9 (8) ◽  
pp. 180 ◽  
Author(s):  
Madeline E. Frost ◽  
Veronica L. Peterson ◽  
Clark W. Bird ◽  
Brian McCool ◽  
Derek A. Hamilton
Keyword(s):  
Nucleus Accumbens ◽  
Insular Cortex ◽  
Ethanol Exposure ◽  
Dendritic Morphology ◽  
Neuronal Morphology ◽  
Prelimbic Cortex ◽  
Spine Density ◽  
Sprague Dawley ◽  
Nucleus Accumbens Core ◽  
Dendritic Length

The present study investigated the effects of chronic intermittent ethanol exposure and withdrawal on dendritic morphology and spine density in the agranular insular and prelimbic cortices. Adult male Sprague–Dawley rats were passively exposed to vaporized ethanol (~37 mg/L; 12 h/day) or air (control) for ten consecutive days. Dendritic length, branching, and spine density were quantified in layer II/III pyramidal neurons 24 hours or seven days following the final ethanol exposure. Compared to unexposed control animals there were structural alterations on neurons in the prelimbic cortex, and to a lesser extent the agranular insular cortex. The most prominent ethanol-related differences were the transient increases in dendritic length and branching in prelimbic neurons at 24 h post-cessation, and increased mushroom-shaped spines at seven days post-cessation. The results obtained in the prelimbic cortex are the opposite of those previously reported in the nucleus accumbens core (Peterson, et al. 2015), suggesting that these regions undergo distinct functional adaptations following ethanol exposure and withdrawal.

Changes in Dendritic Spine Density and Inhibitory Perisomatic Connectivity onto Medium Spiny Neurons in l-Dopa-Induced Dyskinesia

2019 ◽  
Vol 56 (9) ◽  
pp. 6261-6275 ◽  
Author(s):  
G. Gomez ◽  
M. V. Escande ◽  
L. M. Suarez ◽  
L. Rela ◽  
J. E. Belforte ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Medium Spiny Neurons ◽  
Spine Density ◽  
Spiny Neurons ◽  
Dendritic Spine Density

scholarly journals Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training

2016 ◽  
Vol 113 (42) ◽  
pp. E6516-E6525 ◽  
Author(s):  
Paola C. Bello-Medina ◽  
Gonzalo Flores ◽  
Gina L. Quirarte ◽  
James L. McGaugh ◽  
Roberto A. Prado Alcalá
Keyword(s):  
Memory Consolidation ◽  
Dorsal Striatum ◽  
Inhibitory Avoidance ◽  
Brain Structures ◽  
Brain Regions ◽  
Medium Spiny Neurons ◽  
Spine Density ◽  
Spiny Neurons ◽  
Intense Training ◽  
Transfer Of Information

A growing body of evidence indicates that treatments that typically impair memory consolidation become ineffective when animals are given intense training. This effect has been obtained by treatments interfering with the neural activity of several brain structures, including the dorsal striatum. The mechanisms that mediate this phenomenon are unknown. One possibility is that intense training promotes the transfer of information derived from the enhanced training to a wider neuronal network. We now report that inhibitory avoidance (IA) induces mushroom spinogenesis in the medium spiny neurons (MSNs) of the dorsal striatum in rats, which is dependent upon the intensity of the foot-shock used for training; that is, the effect is seen only when high-intensity foot-shock is used in training. We also found that the relative density of thin spines was reduced. These changes were evident at 6 h after training and persisted for at least 24 h afterward. Importantly, foot-shock alone did not increase spinogenesis. Spine density in MSNs in the accumbens was also increased, but the increase did not correlate with the associative process involved in IA; rather, it resulted from the administration of the aversive stimulation alone. These findings suggest that mushroom spines of MSNs of the dorsal striatum receive afferent information that is involved in the integrative activity necessary for memory consolidation, and that intense training facilitates transfer of information from the dorsal striatum to other brain regions through augmented spinogenesis.

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