Septic Knee Arthritis Caused by Group B Salmonella Species in a Patient with Systemic Lupus Erythematosus

2011 ◽  
Vol 46 (4) ◽  
pp. 340
Author(s):  
Choong-Hyeok Choi ◽  
Rae-Hyung Lee ◽  
Jin-Kyu Lee
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Knee Arthritis ◽  
Group B ◽  
Septic Knee Arthritis

Bilateral Femoral Osteomyelitis with Knee Arthritis due to Salmonella enteritidis in a Patient with Systemic Lupus Erythematosus

2001 ◽  
Vol 20 (1) ◽  
pp. 53-56 ◽  
Author(s):  
U. Picillo ◽  
G. Italiano ◽  
M. R. Marcialis ◽  
F. Ginolfi ◽  
G. Abbate ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Salmonella Enteritidis ◽  
Systemic Lupus ◽  
Knee Arthritis

scholarly journals Invasive Group B Streptococcal Disease in Two Pediatric Patients with Systemic Lupus Erythematosus

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Dongning Wu ◽  
Kenneth Bromberg ◽  
Roberto Jodorkovsky
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Pediatric Patients ◽  
High Morbidity ◽  
Systemic Lupus ◽  
Invasive Group ◽  
Pediatric Age Group ◽  
Immunosuppressive Medication ◽  
Group B Streptococcal Disease ◽  
Group B

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with high morbidity and mortality, often caused by infection. We report two patients with SLE who were treated with steroids and immunosuppressive medication and then developed invasive Group BStreptococcus(GBS) infections. While GBS infection is rare in the nonneonatal pediatric age group, GBS should be considered when treating SLE patients presenting with signs of infection.

scholarly journals More Consistent Antimalarial Intake in First 5 Years of Disease Is Associated with Better Prognosis in Patients with Systemic Lupus Erythematosus

2017 ◽  
Vol 45 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Rattapol Pakchotanon ◽  
Dafna D. Gladman ◽  
Jiandong Su ◽  
Murray B. Urowitz
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Multivariable Analysis ◽  
Damage Index ◽  
Retinal Toxicity ◽  
Systemic Lupus ◽  
Group A ◽  
Group B

Objective.To examine whether more consistent use of antimalarial agents (AM) leads to better results in systemic lupus erythematosus (SLE).Methods.From a longitudinal cohort study, we identified inception patients with a minimum of 5 years of followup. They were divided into 3 groups: patients who took AM > 60% of the time (group A), those who took AM < 60% of the time (group B), and those who did not receive AM (group C) during the first 5 years of followup. Outcomes included increase in Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), flare, achieving low disease activity (LDA), adjusted mean Systemic Lupus Erythematosus Disease Activity Index 2000, cumulative doses of steroids (CMS), and AM-related retinal toxicity. Regression analysis models were constructed to identify predictors of the outcomes.Results.There were 459 patients identified: 236 (51.4%) in group A, 88 (19.2%) in group B, and 135 (29.4%) in group C. The changes in SDI, flare event, and CMS were significantly lower in group A, which more often achieved LDA. Multivariable analysis revealed that the patients in group A had a lower risk of increasing SDI and were more likely to achieve LDA at Year 5 compared to the patients in group C. Patients taking AM had lower CMS over the 5 years of followup. There was only 1 patient with AM-related retinal toxicity in each group.Conclusion.More consistent use of an AM over the first 5 years of SLE is associated with better outcomes.

scholarly journals Circulating Endothelial Cells as a Marker of Vascular Dysfunction in Patients With Systemic Lupus Erythematosus by Real-Time Polymerase Chain Reaction

2011 ◽  
Vol 135 (11) ◽  
pp. 1482-1485 ◽  
Author(s):  
Fadia M. Attia ◽  
Ahmed Maaty ◽  
Fawzy Attia Kalil
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Disease Activity Index ◽  
Systemic Lupus ◽  
Double Stranded Dna ◽  
Group A ◽  
Dna Antibodies ◽  
Group B

Context.—Systemic lupus erythematosus (SLE) is associated with an increased risk of atherosclerosis; endothelial dysfunction represents the first step in its pathogenesis. Objective.—To assess endothelial dysfunction in SLE by circulating endothelial cells (CECs) and to characterize SLE-specific factors that contribute to its appearance. Design.—Case-control study was conducted on 60 subjects, divided into 2 groups: group A (30 patients with SLE) and group B (30 healthy sex- and age-matched controls). Total cholesterol, triglycerides, antinuclear antibodies, anti–double-stranded DNA antibodies, and C3 were determined in all patients. Systemic lupus erythematosus activity was assessed using the SLE Disease Activity Index. Endothelial function was assessed by means of flow-mediated dilation of the brachial artery using B-mode ultrasonography and relative quantification of CD 146 mRNA by real-time polymerase chain reaction. Results.—The group of SLE patients was formed of 20 females and 10 males, with a mean age of 31.16 ± 9.69 years. The values of SLE-specific tests and SLE Disease Activity Index were represented by anti–double-stranded DNA antibodies 160 ± 40.5, C3 68.91 ± 11.91 mg/dL, total cholesterol 188.66 ± 49.63 mg/dL, triglycerides 143.41 ± 46.26 mg/dL, and SLE Disease Activity Index 12.66 ± 3.70. Values for flow-mediated dilation were 8.85% ± 2.02% (group A) and 20.33% ± 6.19% (group B), P &lt; .001, and CECs were 300 ± 40.5 μL−1 blood (group A) and 10 ± 2.5 μL−1 blood (group B). The statistical analysis showed a strong inverse correlation between CECs and SLE Disease Activity Index, a strong correlation between CECs and C3, a strong correlation between CECs and anti–double-stranded DNA antibodies, and a moderate inverse correlation between CECs and total cholesterol. Conclusion.—Endothelial dysfunction is present in SLE patients even in the absence of traditional cardiovascular risk factors due to disease activity.

scholarly journals Significance of anti-ribonucleoprotein (RNP) antibody and anti-Smith (anti-Sm) antibody among patients with SLE or MCTD

2020 ◽  
Author(s):  
Natsuki Shima ◽  
Naoki Sawa ◽  
Toshiharu Ueno ◽  
Hiroki Mizuno ◽  
Tatsuya Suwabe ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Membranous Nephropathy ◽  
Antinuclear Antibody ◽  
Systemic Lupus ◽  
Renal Histology ◽  
Group A ◽  
Group B ◽  
Group D

Abstract Background The significance of anti-ribonucleoprotein (RNP) antibody and anti-Smith (anti-Sm) antibody remains unclear in patients with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MCTD). Methods Thirty patients were retrospectively enrolled in this study. They were all positive for antinuclear antibody (ANA) and anti-RNP antibody, were diagnosed with SLE(n = 25) or MCTD(n = 5), and underwent renal biopsy at our hospital between January 1990 and December 2014. These 30 patients were classified into 4 groups based on their anti-dsDNA and anti-Sm status. Renal histology was classified into 3 patterns, including pure subepithelial membranous nephropathy (MN), mesangial and/or subendothelial lesions (MES), and MN combined with MES. Results Comparison between groups A [dsDNA(-)and SM(-)] and B༻dsDNA(-)and SM(+)༽ revealed that group A was with pure MN(n = 5) + MN + MES(n = 4) + MES(n = 1) and normocomplementemia, while group B was with MES + MN(n = 2) + MES(n = 5) and hypocomplementemia. Comparison between groups C༻dsDNA(+)and SM(-)༽ and D༻dsDNA(+)and SM(+)༽showed that group C was with pure MES and normocomplementemia, while group D was with MN + MES(n = 4) + pure MES(n = 3) and hypocomplementemia. Among 10 patients in group A, all 5 patients with MCTD were categorized as pure MN, while the 5 patients with SLE were MN + MES or pure MES. Conclusion Among patients showing positivity for anti-RNP antibody alone, those with MCTD seem likely to develop pure MN, while those with SLE tend to have MES as well as MN.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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