scholarly journals Enhanced Tendon-to-Bone Healing of Chronic Rotator Cuff Tears by Bone Marrow Aspirate Concentrate in a Rabbit Model

2018 ◽  
Vol 10 (1) ◽  
pp. 99 ◽  
Author(s):  
Xiao Ning Liu ◽  
Cheol-Jung Yang ◽  
Ji Eui Kim ◽  
Zhen Wu Du ◽  
Ming Ren ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Bone Marrow Aspirate ◽  
Rabbit Model ◽  
Rotator Cuff Tears ◽  
Bone Marrow Aspirate Concentrate

scholarly journals Bone marrow mesenchymal stem cell-derived exosomes promote rotator cuff tendon-bone healing by promoting angiogenesis and regulating M1 macrophages in rats

2020 ◽  
Author(s):  
Yao Huang ◽  
Bing He ◽  
Lei Wang ◽  
Bin Yuan ◽  
Hao Shu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Rotator Cuff ◽  
Mesenchymal Stem Cell ◽  
Bone Healing ◽  
Umbilical Vein ◽  
Rotator Cuff Tears ◽  
M1 Macrophages ◽  
Rotator Cuff Tendon ◽  
Bone Interface

Abstract Background: Rotator cuff tears (RCTs) often require reconstructive surgery. Tendon-bone healing is critical for the outcome of rotator cuff reconstruction, but the process of tendon-bone healing is complex and difficult. Mesenchymal stem cells (MSCs) are considered to be an effective method to promote tendon-bone healing. MSCs have strong paracrine, anti-inflammatory, immunoregulatory, and angiogenic potential. Recent studies have shown that MSCs achieve many regulatory functions through exosomes. The purpose of this study was to explore the role of bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) in tendon-bone healing. Methods: Our study found that BMSC-Exos promote the proliferation, migration, and angiogenic tube formation of Human Umbilical Vein Endothelial Cells (HUVECs). The mechanism by which BMSC-Exos achieve this may be through the regulation of the angiogenic signaling pathway. In addition, BMSC-Exos can inhibit the polarization of M1 macrophages and inhibit the secretion of proinflammatory factors by M1 macrophages. After rotator cuff reconstruction in rats, BMSC-Exos were injected into the tail vein to analyze their effect on the rotator cuff tendon-bone interface healing. Results: It was confirmed that BMSC-Exos increased the breaking load and stiffness of the rotator cuff after reconstruction in rats, induced angiogenesis around the rotator cuff endpoint, and promoted growth of the tendon-bone interface. Conclusion: BMSC-Exos promote tendon-bone healing after rotator cuff reconstruction in rats by promoting angiogenesis and inhibiting inflammation.

Bone Marrow Aspirate Concentrate in Animal Long Bone Healing

2016 ◽  
Vol 30 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Arianna Gianakos ◽  
Amelia Ni ◽  
Lester Zambrana ◽  
John G. Kennedy ◽  
Joseph M. Lane
Keyword(s):  
Bone Marrow ◽  
Bone Healing ◽  
Bone Marrow Aspirate ◽  
Long Bone ◽  
Bone Marrow Aspirate Concentrate

Bone Marrow Aspirate Concentrate for Bone Healing in Foot and Ankle Surgery

2016 ◽  
Vol 21 (4) ◽  
pp. 839-845 ◽  
Author(s):  
Joshua S. Harford ◽  
Travis J. Dekker ◽  
Samuel B. Adams
Keyword(s):  
Bone Marrow ◽  
Bone Healing ◽  
Bone Marrow Aspirate ◽  
Foot And Ankle ◽  
Bone Marrow Aspirate Concentrate ◽  
Ankle Surgery
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