scholarly journals Glycosphingolipid Biosynthesis during Mitosis

1993 ◽  
Vol 5 (22) ◽  
pp. 143-144
Author(s):  
H. Higashi
Keyword(s):  
Glycosphingolipid Biosynthesis

scholarly journals Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases

2021 ◽  
Vol 22 (5) ◽  
pp. 2737
Author(s):  
Daisy Sproviero ◽  
Stella Gagliardi ◽  
Susanna Zucca ◽  
Maddalena Arigoni ◽  
Marta Giannini ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Extracellular Vesicles ◽  
Small Rnas ◽  
Biomarker Discovery ◽  
Toll Like Receptor ◽  
Neurotrophin Signaling ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing ◽  
Lateral Sclerosis ◽  
Glycosphingolipid Biosynthesis

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common and different miRNA signatures in plasma derived LEVs and SEVs of Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD) patients. LEVs and SEVs were isolated from plasma of patients and healthy volunteers (CTR) by filtration and differential centrifugation and RNA was extracted. Small RNAs libraries were carried out by Next Generation Sequencing (NGS). MiRNAs discriminate all NDs diseases from CTRs and they can provide a signature for each NDs. Common enriched pathways for SEVs were instead linked to ubiquitin mediated proteolysis and Toll-like receptor signaling pathways and for LEVs to neurotrophin signaling and Glycosphingolipid biosynthesis pathway. LEVs and SEVs are involved in different pathways and this might give a specificity to their role in the spreading of the disease. The study of common and different miRNAs transported by LEVs and SEVs can be of great interest for biomarker discovery and for pathogenesis studies in neurodegeneration.

scholarly journals Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis

1984 ◽  
Vol 25 (13) ◽  
pp. 1541-1547
Author(s):  
J D Burczak ◽  
R M Soltysiak ◽  
C C Sweeley
Keyword(s):  
Membrane Bound ◽  
Membrane Bound Enzymes ◽  
Glycosphingolipid Biosynthesis

ChemInform Abstract: Inhibitors of Glycosphingolipid Biosynthesis

ChemInform ◽  
2010 ◽  
Vol 28 (25) ◽  
pp. no-no
Author(s):  
T. KOLTER ◽  
K. SANDHOFF
Keyword(s):  
Glycosphingolipid Biosynthesis

scholarly journals Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide

2005 ◽  
Vol 280 (30) ◽  
pp. 28110-28117 ◽  
Author(s):  
Irfan Y. Tamboli ◽  
Kai Prager ◽  
Esther Barth ◽  
Michael Heneka ◽  
Konrad Sandhoff ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Amyloid Β Peptide ◽  
Β Amyloid ◽  
Glycosphingolipid Biosynthesis

scholarly journals Enhancing the sialylation of recombinant EPO produced in CHO cells via the inhibition of glycosphingolipid biosynthesis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chan-Yeong Kwak ◽  
Seung-Yeol Park ◽  
Chung-Geun Lee ◽  
Nozomu Okino ◽  
Makoto Ito ◽  
...  
Keyword(s):  
Cho Cells ◽  
Glycosphingolipid Biosynthesis

Glycosphingolipid biosynthesis in early chick embryos

1986 ◽  
Vol 160 (3) ◽  
pp. 651-658 ◽  
Author(s):  
Brunhilde FELDING-HABERMANN ◽  
Richard JENNEMANN ◽  
Jurgen SCHMITT ◽  
Herbert WIEGANDT
Keyword(s):  
Chick Embryos ◽  
Glycosphingolipid Biosynthesis
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