scholarly journals Heparan Sulfate Proteoglycans Regulate the Switching of Axon Guidance Cues

2014 ◽  
Vol 26 (150) ◽  
pp. 99-101
Author(s):  
Michiru Ida-Eto
Keyword(s):  
Heparan Sulfate ◽  
Axon Guidance ◽  
Heparan Sulfate Proteoglycans ◽  
Guidance Cues

scholarly journals Axonal Heparan Sulfate Proteoglycans Regulate the Distribution and Efficiency of the Repellent Slit during Midline Axon Guidance

2004 ◽  
Vol 14 (6) ◽  
pp. 499-504 ◽  
Author(s):  
Karl G Johnson ◽  
Aurnab Ghose ◽  
Elizabeth Epstein ◽  
John Lincecum ◽  
Michael B O'Connor ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Axon Guidance ◽  
Heparan Sulfate Proteoglycans

scholarly journals Sugar Antennae for Guidance Signals: Syndecans and Glypicans Integrate Directional Cues for Navigating Neurons

2006 ◽  
Vol 6 ◽  
pp. 1024-1036 ◽  
Author(s):  
Christa Rhiner ◽  
Michael O. Hengartner
Keyword(s):  
Cell Surface ◽  
Axon Guidance ◽  
Neuronal Network ◽  
Neuronal Migration ◽  
Synapse Formation ◽  
Nerve Cells ◽  
Heparan Sulfate Proteoglycans ◽  
Vast Number ◽  
Guidance Cues

Attractive and repulsive signals guide migrating nerve cells in all directions when the nervous system starts to form. The neurons extend thin processes, axons, that connect over wide distances with other brain cells to form a complicated neuronal network. One of the most fascinating questions in neuroscience is how the correct wiring of billions of nerve cells in our brain is controlled. Several protein families are known to serve as guidance cues for navigating neurons and axons. Nevertheless, the combinatorial potential of these proteins seems to be insufficient to sculpt the entire neuronal network and the appropriate formation of connections. Recently, heparan sulfate proteoglycans (HSPGs), which are present on the cell surface of neurons and in the extracellular matrix through which neurons and axons migrate, have been found to play a role in regulating cell migration and axon guidance. Intriguingly, the large number of distinct modifications that can be put onto the sugar side chains of these PGs would in principle allow for an enormous diversity of HSPGs, which could help in regulating the vast number of guidance choices taken by individual neurons. In this review, we will focus on the role of the cell surface HSPGs syndecan and glypican and specific HS modifications in promoting neuronal migration, axon guidance, and synapse formation.

scholarly journals The Heparan Sulfate Proteoglycans Dally-like and Syndecan Have Distinct Functions in Axon Guidance and Visual-System Assembly in Drosophila

2005 ◽  
Vol 15 (9) ◽  
pp. 833-838 ◽  
Author(s):  
Joel M. Rawson ◽  
Brian Dimitroff ◽  
Karl G. Johnson ◽  
Jaime M. Rawson ◽  
Xuecai Ge ◽  
...  
Keyword(s):  
Visual System ◽  
Heparan Sulfate ◽  
Axon Guidance ◽  
Heparan Sulfate Proteoglycans

Localization of cell-surface and basement-membrane heparan-sulfate proteoglycans using the malaria circumsporozoite protein

1994 ◽  
Vol 52 ◽  
pp. 294-295
Author(s):  
U. Frevert ◽  
S. Sinnis ◽  
C. Cerami ◽  
V. Nussenzweig
Keyword(s):  
Heparan Sulfate ◽  
Protein A ◽  
Kidney Tissue ◽  
Plasmodium Species ◽  
Its Region ◽  
Basement Membranes ◽  
Heparan Sulfate Proteoglycans ◽  
Infected Mosquito ◽  
Complement Components ◽  
Region Ii

Malaria sporozoites, which invade hepatocytes within minutes after transmission by an infected mosquito, are covered with the circumsporozoite (CS) protein, which in all Plasmodium species contains the conserved region II-plus. This region is also found as a cell-adhesive motif in a variety of host proteins like thrombospondin, properdin and the terminal complement components.The CS protein with its region II-plus specifically binds to heparan sulfate proteoglycans (HSPG) on the basolateral surface of hepatocytes in the space of Disse (FIG. 1), to certain basolateral cell membranes and basement membranes of the kidney (FIG. 2) as well as to heparin in the granules of connective tissue mast cells. The distribution of the HSPG receptors for the CS protein was examined by incubation of Lowicryl K4M or LR White sections of liver and kidney tissue with the recombinant CS ligand, whose binding sites were detected with a monoclonal anti-CS antibody and protein A gold.

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