Development of Fluorescent Substrate for Glycan Processing Glycosidase, and Screening of the Novel Glycosidase Inhibitor

2020 ◽  
Vol 32 (190) ◽  
pp. E201-E204
Author(s):  
Kazuki Miura ◽  
Wataru Hakamata
Keyword(s):  
The Novel ◽  
Fluorescent Substrate ◽  
Glycosidase Inhibitor

Synthesis of zwitterionic selenonium and sulfonium sulfates from D-mannose as potential glycosidase inhibitors

2006 ◽  
Vol 84 (4) ◽  
pp. 497-505 ◽  
Author(s):  
Hui Liu ◽  
B Mario Pinto
Keyword(s):  
Membered Ring ◽  
The Novel ◽  
Glycosidase Inhibitors ◽  
Naturally Occurring ◽  
Structure Activity ◽  
Glycosidase Inhibitor ◽  
Ring Core

Four chain-extended analogues of the naturally occurring glycosidase inhibitor salacinol were synthesized for structure–activity studies with different glycosidase enzymes. The syntheses involved the reaction of isopropylidene-protected 1,4-thio- and 1,4-seleno-D-talitols and 1,5-thio- and 1,5-seleno-L-gulitols, derived from D-mannose, with a benzylidene- and isopropylidene-protected 1,3-cyclic sulfate, also derived from D-mannose. Deprotection of the products afforded the novel selenonium and sulfonium sulfates composed of heterocyclic five- and six-membered ring core structures with pendant polyhydroxylated, acyclic chains of six carbon atoms.Key words: glycosidase inhibitors, zwitterionic selenonium and sulfonium sulfates, cyclic sulfate

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon

The Involuntary Capture of Attention by Sound

2010 ◽  
Vol 57 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Fabrice B. R. Parmentier ◽  
Pilar Andrés
Keyword(s):  
Older Adults ◽  
Mismatch Negativity ◽  
Visual Task ◽  
The Novel ◽  
Auditory Oddball ◽  
Current Trial ◽  
Electrophysiological Responses ◽  
Electrophysiological Studies ◽  
The Cross ◽  
Task Sets

The presentation of auditory oddball stimuli (novels) among otherwise repeated sounds (standards) triggers a well-identified chain of electrophysiological responses: The detection of acoustic change (mismatch negativity), the involuntary orientation of attention to (P3a) and its reorientation from the novel. Behaviorally, novels reduce performance in an unrelated visual task (novelty distraction). Past studies of the cross-modal capture of attention by acoustic novelty have typically discarded from their analysis the data from the standard trials immediately following a novel, despite some evidence in mono-modal oddball tasks of distraction extending beyond the presentation of deviants/novels (postnovelty distraction). The present study measured novelty and postnovelty distraction and examined the hypothesis that both types of distraction may be underpinned by common frontally-related processes by comparing young and older adults. Our data establish that novels delayed responses not only on the current trial and but also on the subsequent standard trial. Both of these effects increased with age. We argue that both types of distraction relate to the reconfiguration of task-sets and discuss this contention in relation to recent electrophysiological studies.

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