The Biosynthetic Pathway of 1,6-Branched β-(1,3)-Glucan, the Biopolymer That Constitutes the Core Structure of Fungal Cell Walls

2020 ◽  
Vol 32 (188) ◽  
pp. E119-E125
Author(s):  
Rui Tada ◽  
Vishukumar Aimanianda
Keyword(s):  
Cell Walls ◽  
Biosynthetic Pathway ◽  
Core Structure ◽  
Fungal Cell ◽  
The Core ◽  
Fungal Cell Walls

Rapid determination of binding parameters of chitin binding domains using chitin-coated quartz crystal microbalance sensor chips

The Analyst ◽  
2018 ◽  
Vol 143 (21) ◽  
pp. 5255-5263 ◽  
Author(s):  
Stephan Vogt ◽  
Marco Kelkenberg ◽  
Tanja Nöll ◽  
Benedikt Steinhoff ◽  
Holger Schönherr ◽  
...  
Keyword(s):  
Cell Walls ◽  
Quartz Crystal ◽  
Fungal Infections ◽  
Rapid Determination ◽  
Binding Parameters ◽  
Fungal Cell ◽  
Binding Domains ◽  
Quartz Crystal Microbalance Sensor ◽  
Fungal Cell Walls

Chitin present in fungal cell walls has been considered as a diagnostic polymer for the detection of fungal infections.

scholarly journals Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Kátia Santana Cruz ◽  
Emerson Silva Lima ◽  
Marcia de Jesus Amazonas da Silva ◽  
Erica Simplício de Souza ◽  
Andreia Montoia ◽  
...  
Keyword(s):  
Cell Wall ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Cryptococcus Neoformans ◽  
Active Compound ◽  
Cell Walls ◽  
Human Fibroblasts ◽  
Lead Compound ◽  
Fungal Cell ◽  
Fungal Cell Walls

Background. Cryptococcosis is a fungal disease of bad prognosis due to its pathogenicity and the toxicity of the drugs used for its treatment. The aim of this study was to investigate the medicinal potential of carbazole and β-carboline alkaloids and derivatives against Cryptococcus neoformans and C. gattii. Methods. MICs were established in accordance with the recommendations of the Clinical and Laboratory Standards Institute for alkaloids and derivatives against C. neoformans and C. gattii genotypes VNI and VGI, respectively. A single active compound was further evaluated against C. neoformans genotypes VNII, VNIII, and VNIV, C. gattii genotypes VGI, VGIII, and VGIV, Candida albicans ATCC 36232, for cytotoxicity against the MRC-5 lineage of human fibroblasts and for effects on fungal cells (cell wall, ergosterol, and leakage of nucleic acids). Results. Screening of 11 compounds revealed 8-nitroharmane as a significant inhibitor (MIC 40 μg/mL) of several C. neoformans and C. gattii genotypes. It was not toxic to fibroblasts (IC50 > 50 µg/mL) nor did it alter fungal cell walls or the concentration of ergosterol in C. albicans or C. neoformans. It increased leakage of substances that absorb at 260 nm. Conclusions. The synthetic β-carboline 8-nitroharmane significantly inhibits pathogenic Cryptococcus species and is interesting as a lead compound towards new therapy for Cryptococcus infections.

scholarly journals Autolytic Enzymes in Fungal Cell Walls

1966 ◽  
Vol 42 (1) ◽  
pp. 39-42 ◽  
Author(s):  
R. MITCHELL ◽  
N. SABAR
Keyword(s):  
Cell Walls ◽  
Fungal Cell ◽  
Fungal Cell Walls

Polymorphism in crystalline (1→3)-α-d-glucan from fungal cell-walls

1979 ◽  
Vol 71 (1) ◽  
pp. 51-64 ◽  
Author(s):  
Jaap Jelsma ◽  
Dirk R. Kreger
Keyword(s):  
Cell Walls ◽  
Fungal Cell ◽  
Fungal Cell Walls

scholarly journals Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls

2020 ◽  
Vol 16 (1) ◽  
pp. e1007927 ◽  
Author(s):  
Ingrida Vendele ◽  
Janet A. Willment ◽  
Lisete M. Silva ◽  
Angelina S. Palma ◽  
Wengang Chai ◽  
...  
Keyword(s):  
Cell Walls ◽  
Fungal Cell ◽  
Lectin Receptor ◽  
Fungal Cell Walls
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