IL-10 as a Th2 Cytokine: Differences Between Mice and Humans

2021 ◽  
Vol 207 (9) ◽  
pp. 2205-2215
Author(s):  
Mahima T. Rasquinha ◽  
Meghna Sur ◽  
Ninaad Lasrado ◽  
Jay Reddy
Keyword(s):  
Th2 Cytokine

The impact of Zataria multiflora Boiss extract on in vitro and in vivo Th1/Th2 cytokine (IFN-γ/IL4) balance

2013 ◽  
Vol 150 (3) ◽  
pp. 1024-1031 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Sakine Shahmohammadi Mehrjardi ◽  
Abadorrahim Rezaee ◽  
Houshang Rafatpanah ◽  
Sediqeh Jalali
Keyword(s):  
Zataria Multiflora ◽  
Th2 Cytokine ◽  
Ifn Γ ◽  
The Impact

scholarly journals Transcription Factors in the Development and Function of Group 2 Innate Lymphoid Cells

2019 ◽  
Vol 20 (6) ◽  
pp. 1377 ◽  
Author(s):  
Takashi Ebihara ◽  
Ichiro Taniuchi
Keyword(s):  
Transcription Factors ◽  
Physiological State ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Th2 Cytokine ◽  
Parasitic Worm ◽  
Group 2 ◽  
And Function

Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells and are a major source of innate TH2 cytokine secretion upon allergen exposure or parasitic-worm infection. Accumulating studies have revealed that transcription factors, including GATA-3, Bcl11b, Gfi1, RORα, and Ets-1, play a role in ILC2 differentiation. Recent reports have further revealed that the characteristics and functions of ILC2 are influenced by the physiological state of the tissues. Specifically, the type of inflammation strongly affects the ILC2 phenotype in tissues. Inhibitory ILC2s, memory-like ILC2s, and ex-ILC2s with ILC1 features acquire their characteristic properties following exposure to their specific inflammatory environment. We have recently reported a new ILC2 population, designated as exhausted-like ILC2s, which emerges after a severe allergic inflammation. Exhausted-like ILC2s are featured with low reactivity and high expression of inhibitory receptors. Therefore, for a more comprehensive understanding of ILC2 function and differentiation, we review the recent knowledge of transcriptional regulation of ILC2 differentiation and discuss the roles of the Runx transcription factor in controlling the emergence of exhausted-like ILC2s. The concept of exhausted-like ILC2s sheds a light on a new aspect of ILC2 biology in allergic diseases.

Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis

1996 ◽  
Vol 26 (7) ◽  
pp. 1511-1518 ◽  
Author(s):  
Claudia Mauri ◽  
Richard O. Williams ◽  
Marita Walmsley ◽  
Marc Feldmann
Keyword(s):  
Collagen Induced Arthritis ◽  
Th2 Cytokine

scholarly journals The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

Immunity ◽  
1998 ◽  
Vol 8 (1) ◽  
pp. 115-124 ◽  
Author(s):  
Hiroki Yoshida ◽  
Hiroshi Nishina ◽  
Hiroaki Takimoto ◽  
Luc E.M Marengère ◽  
Andrew C Wakeham ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lymphocyte Proliferation ◽  
Cytokine Production ◽  
Th2 Cytokine
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