scholarly journals COVID-19 as an Acute Inflammatory Disease

2020 ◽  
Vol 205 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Rose H. Manjili ◽  
Melika Zarei ◽  
Mehran Habibi ◽  
Masoud H. Manjili
Keyword(s):  
Inflammatory Disease ◽  
Acute Inflammatory Disease

Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease

Blood ◽  
2004 ◽  
Vol 104 (5) ◽  
pp. 1375-1382 ◽  
Author(s):  
Jack H. Crawford ◽  
Balu K. Chacko ◽  
Heather M. Pruitt ◽  
Barbora Piknova ◽  
Neil Hogg ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Inflammatory Disease ◽  
Cyclic Guanosine Monophosphate ◽  
Experimental Models ◽  
Guanosine Monophosphate ◽  
Vascular Pathology ◽  
Integral Role ◽  
Plasma Nitrite ◽  
Acute Inflammatory Disease

Abstract Sepsis is an acute inflammatory disease characterized by dysfunctional blood flow and hypotension. Nitric oxide (NO) is elevated during sepsis and plays an integral role in the associated vascular pathology. However, precise mechanisms and functions of NO in sepsis remain unclear. In this study, we show that red blood cells (RBCs) are foci for nitrosative reactions during acute inflammation, resulting in the formation of cells that can promote systemic vascular relaxation in an uncontrolled manner. Specifically, using experimental models of endotoxemia and surgical sepsis, NO adducts were found in the RBCs, including S-nitrosohemoglobin (SNOHb). These RBCs, referred to as septic RBCs, spontaneously stimulated vasodilation in a manner consistent with elevated SNOHb concentrations. Moreover, relaxation was cyclic guanosine monophosphate (cGMP) dependent and was inhibited by RBC lysis and glutathione but not by the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5 tetramethylimidazoline 1-oxyl 3-oxide (C-PTIO). The potential mechanism of septic RBC–mediated vasorelaxation is discussed and may involve the intermediate, nitroxyl (HNO). Coupled with data showing that NO adducts in septic RBCs were dependent on the inducible nitric oxide synthase and correlated with plasma nitrite, these findings provide a novel framework to understand mechanisms underlying dysfunctional blood flow responses during sepsis. Specifically, the concept that RBCs directly mediate systemic hypotension through NO-dependent mechanisms is discussed.

scholarly journals Resistin - concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease

2003 ◽  
Vol 147 (1) ◽  
pp. 63-69 ◽  
Author(s):  
David Stejskal ◽  
Sylva Adamovska ◽  
Josef Bartek ◽  
Renata Jurakova ◽  
Jitka Proskova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Inflammatory Disease ◽  
Acute Inflammatory Disease

scholarly journals Correction to: Influence of cancer and acute inflammatory disease on taste perception: a clinical pilot study

2019 ◽  
Vol 27 (4) ◽  
pp. 1579-1579 ◽  
Author(s):  
P. Schalk ◽  
M. Kohl ◽  
H. J. Herrmann ◽  
R. Schwappacher ◽  
M. E. Rimmele ◽  
...  
Keyword(s):  
Pilot Study ◽  
Inflammatory Disease ◽  
Taste Perception ◽  
Acute Inflammatory Disease

scholarly journals Nutrition, Inflammation, and Acute Pancreatitis

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Max Petrov
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Disease ◽  
Clinical Management ◽  
Treatment Modality ◽  
Anti Inflammatory ◽  
Acute Inflammatory Disease

Acute pancreatitis is acute inflammatory disease of the pancreas. Nutrition has a number of anti-inflammatory effects that could affect outcomes of patients with pancreatitis. Further, it is the most promising nonspecific treatment modality in acute pancreatitis to date. This paper summarizes the best available evidence regarding the use of nutrition with a view of optimising clinical management of patients with acute pancreatitis.

scholarly journals Free erythrocyte porphyrin: hemoglobin ratios, serum ferritin, and transferrin saturation levels during treatment of infants with iron- deficiency anemia

Blood ◽  
1977 ◽  
Vol 49 (3) ◽  
pp. 455-462
Author(s):  
WJ Thomas ◽  
HM Koenig ◽  
AL Jr Lightsey ◽  
R Green
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Inflammatory Disease ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Serum Transferrin ◽  
Present Measurement ◽  
Prompt Diagnosis ◽  
Acute Inflammatory Disease

Free erythrocyte porphyrin:hemoglobin (FEP:Hb) ratios were determined on 20 infants with iron-deficiency anemia. FEB:Hb ratios were compared with simultaneously drawn serum ferritin and serum transferrin saturation levels. FEP:Hb ratios dropped steadily during treatment of the anemic infants, but remained elevated compared to age-matched nonanemic infants, until the anemia was corrected. FEP:Hb ratios detected iron deficiency when acute inflammatory disease was present. Serum ferritin levels and transferrin saturation failed to detect iron deficiency after iron therapy was started or when acute inflammatory disease was present. Measurement of FEP:Hb ratios is a reliable and practical way to make a prompt diagnosis of iron-deficiency anemia in infants.

scholarly journals Correction to: Influence of cancer and acute inflammatory disease on taste perception: a clinical pilot study

2020 ◽  
Vol 28 (5) ◽  
pp. 2431-2431
Author(s):  
P. Schalk ◽  
M. Kohl ◽  
H. J. Herrmann ◽  
R. Schwappacher ◽  
M. E. Rimmele ◽  
...  
Keyword(s):  
Pilot Study ◽  
Inflammatory Disease ◽  
Taste Perception ◽  
Acute Inflammatory Disease

scholarly journals DIAGNOSIS SEPSIS MENGGUNAKAN PROCALCITONIN

2018 ◽  
Vol 12 (3) ◽  
pp. 127
Author(s):  
Buchori . ◽  
Prihatini .
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Critically Ill ◽  
Sedimentation Rate ◽  
Inflammatory Disease ◽  
Critically Ill Patients ◽  
Clinical Signs ◽  
Erythrocyte Sedimentation ◽  
Conventional Methods ◽  
Sepsis Detection ◽  
Acute Inflammatory Disease

Sepsis can be difficult to distinguish from non-infections conditions in critically ill patients with clinical signs of inflammation.Diagnosis of sepsis by conventional methods (erythrocyte sedimentation rate, CRP) are difficult to be confirmed. Procalcitonin (PCT)was found in 1990s, which number was enhanced in bacterial and fungi infections. Procalcitonin (PCT) is calcitonin (PCT) prohormonwhich presence increasing in sepsis and severe diseases. Procalcitonin (PCT) can be measured in serum and plasma by immunolometricmethods (immunoassay). The process needs 30 minutes to 1.5 hours depends on the selected method. It can be hope in the future,that methods of Procalcitonin (PCT) measurement can used as a means for early sepsis detection and can distinguish between systemicinfection and acute inflammatory disease.

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