IL-9 Abrogates the Metastatic Potential of Breast Cancer by Controlling Extracellular Matrix Remodeling and Cellular Contractility

2021 ◽  
pp. ji2000383
Author(s):  
Sreya Das ◽  
Vishakha Surve ◽  
Soumitra Marathe ◽  
Siddhi Wad ◽  
Atharva Karulkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Metastatic Potential ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals Tracking Extracellular Matrix Remodeling in Lungs Induced by Breast Cancer Metastasis. Fourier Transform Infrared Spectroscopic Studies

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 236 ◽  
Author(s):  
Karolina Chrabaszcz ◽  
Katarzyna Kaminska ◽  
Karolina Augustyniak ◽  
Monika Kujdowicz ◽  
Marta Smeda ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Fourier Transform ◽  
Cancer Metastasis ◽  
Fourier Transform Infrared ◽  
Muscle Cells ◽  
Breast Cancer Metastasis ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Large Area

This work focused on a detailed assessment of lung tissue affected by metastasis of breast cancer. We used large-area chemical scanning implemented in Fourier transform infrared (FTIR) spectroscopic imaging supported with classical histological and morphological characterization. For the first time, we differentiated and defined biochemical changes due to metastasis observed in the lung parenchyma, atelectasis, fibrous, and muscle cells, as well as bronchi ciliate cells, in a qualitative and semi-quantitative manner based on spectral features. The results suggested that systematic extracellular matrix remodeling with the progress of the metastasis process evoked a decrease in the fraction of the total protein in atelectasis, fibrous, and muscle cells, as well as an increase of fibrillar proteins in the parenchyma. We also detected alterations in the secondary conformations of proteins in parenchyma and atelectasis and changes in the level of hydroxyproline residues and carbohydrate moieties in the parenchyma. The results indicate the usability of FTIR spectroscopy as a tool for the detection of extracellular matrix remodeling, thereby enabling the prediction of pre-metastatic niche formation.

Estrogen-regulated extracellular matrix remodeling genes in MCF-7 breast cancer cells

Gene Reports ◽  
2016 ◽  
Vol 3 ◽  
pp. 14-21 ◽  
Author(s):  
J.M. Dixcy Jaba Sheeba ◽  
C.M. Mohan ◽  
Hussain Marine ◽  
Deb Gauri ◽  
Kumar Neeraj ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Mcf 7

scholarly journals The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.

1992 ◽  
Vol 119 (4) ◽  
pp. 997-1002 ◽  
Author(s):  
O Lefebvre ◽  
C Wolf ◽  
J M Limacher ◽  
P Hutin ◽  
C Wendling ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Extracellular Matrix ◽  
Mammary Gland ◽  
Mouse Mammary Gland ◽  
Limb Bud ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Breast Carcinomas ◽  
Stromelysin 3

We have cloned from a mouse placenta cDNA library a mouse homologue of the human stromelysin-3 (ST3) cDNA, which codes for a putative matrix metalloproteinase expressed in breast carcinomas. The ST3 protein is well conserved between humans and mice, and the pattern of ST3 gene expression is similar in both species, and shows expression in the placenta, in the uterus, and during limb bud morphogenesis. We show that the ST3 gene can also be expressed in the normal mouse mammary gland. ST3 gene expression was not detected during mammary growth, neither in virgin nor in pregnant mice, but was specifically observed during postlactating involution of the gland, an apoptotic process associated with intense extracellular matrix remodeling. ST3 transcripts were found in fibroblasts immediately surrounding degenerative ducts, suggesting that ST3 gene expression may be associated with the basement membrane dissolution, which occurs during mammary gland involution. Since the ST3 gene is also specifically expressed in fibroblastic cells surrounding invasive neoplastic cells of breast carcinomas, we suggest that ST3 is implicated in extracellular matrix remodeling processes common to mammary apoptosis and breast cancer progression.

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

scholarly journals Aryl Hydrocarbon Receptor Activation Impairs Extracellular Matrix Remodeling during Zebra Fish fin Regeneration

2006 ◽  
Vol 95 (1) ◽  
pp. 215-226 ◽  
Author(s):  
Eric A. Andreasen ◽  
Lijoy K. Mathew ◽  
Christiane V. Löhr ◽  
Rachelle Hasson ◽  
Robert L. Tanguay
Keyword(s):  
Extracellular Matrix ◽  
Aryl Hydrocarbon Receptor ◽  
Receptor Activation ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Zebra Fish ◽  
Fin Regeneration ◽  
Aryl Hydrocarbon
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