scholarly journals An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype

2020 ◽  
Vol 205 (5) ◽  
pp. 1318-1322
Author(s):  
Janardan P. Pandey ◽  
Jan Olsson ◽  
Bodil Weidung ◽  
Ronald T. Kothera ◽  
Anders Johansson ◽  
...  
Keyword(s):  
Risk Factor ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Marker Genotype ◽  
Strong Risk Factor

scholarly journals Correction: An Ig γ Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E ε4 Genotype

2020 ◽  
Vol 205 (11) ◽  
pp. 3230-3230
Author(s):  
Janardan P. Pandey ◽  
Jan Olsson ◽  
Bodil Weidung ◽  
Ronald T. Kothera ◽  
Anders Johansson ◽  
...  
Keyword(s):  
Risk Factor ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Marker Genotype ◽  
Strong Risk Factor

scholarly journals PAŽINTINIŲ GEBĖJIMŲ IR APOLIPOPROTEINO E Ɛ4 GENOTIPO SĄSAJOS: SISTEMINĖ APŽVALGA

Psichologija ◽  
2012 ◽  
Vol 46 ◽  
pp. 123-134
Author(s):  
Laura Sapranavičiūtė ◽  
Abdonas Tamošiūnas
Keyword(s):  
Risk Factor ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Longitudinal Studies ◽  
Cognitive Functions ◽  
Prognostic Value ◽  
Healthy Adults ◽  
Cognitively Impaired

Senėjimo problemos kontekste pažintinių gebėjimų prastėjimas tampa vis aktualesnė tema. Yra duomenų, kad APOE ɛ4 genotipas prognozuoja prastesnius pažintinius gebėjimus. Taigi, kyla poreikis išsiaiškinti, kurie pažintinių gebėjimų komponentai ir jų pokyčiai siejasi su APOE ɛ4 genotipu. Šio straipsnio tikslas – sisteminės analizės metodu apžvelgti mokslinius tyrimus, analizavusius pažintinių gebėjimų ir APOE ɛ4 genotipo sąsajas.Ankstesnių tyrimų rezultatai atskleidžia, kad turintieji APOE ɛ4 alelį pasižymi prastesniais pažintiniais gebėjimais, palyginti su asmenimis, neturinčiais APOE ɛ4. Dauguma tyrimų įrodo, kad APOE ɛ4 genotipas susijęs su prastesne atmintimi ir vykdomosios funkcijos rezultatais. Kiek rečiau aptinkami APOE ɛ4 ir dėmesio ryšiai. O verbaliniai ir samprotavimo gebėjimai su šio geno polimorfizmu dažniausiai nesiejami. Manoma, kad APOE ɛ4 genotipas gali turėti įtakos pažintinių gebėjimų prastėjimui, tačiau lieka neaiški šio geno polimorfizmo įtaka pažintinių gebėjimų prastėjimui, pasireiškus Alzheimerio ligai.Taigi, APOE ɛ4 genotipas gali būti rizikos veiksnys, susijęs tiek su natūraliu, tiek su patologiniu pažintinių gebėjimų prastėjimu. Tačiau tolesni APOE ɛ4 genotipo ir pažintinių gebėjimų sąsajų tyrimai yra būtimi.Pagrindiniai žodžiai: pažintiniai gebėjimai, APOE ɛ4 genotipas.ASSOCIATIONS BETWEEN COGNITIVE FUNCTIONS AND APOLIPOPROTEIN E Ɛ4 GENOTYPE: SYSTEMIC REVIEWLaura Sapranavičiūtė, Abdonas TamošiūnasSummaryDeterioration of cognitive functions is becoming more and more important issue in context of aging. So there is the growing interest in studies looking for the risk factors of deterioration of cognitive functions. Apolipoprotein E is a plasma protein whose major function is lipids transportation. APOE ɛ4 allele of the Apolipoprotein E gene is known as a risk factor of Alzheimer disease. Previous researchers stated, that APOE ɛ4 also might be related to cognitive performance in normal aging. However results of previous studies are quit confusing: different studies established various associations between APOE ɛ4 and specific cognitive functions. Moreover, longitudinal studies failed to establish prognostic value of APOE ɛ4 genotype to different levels of cognitive functions deterioration. So the purpose of this study is to review prospective, observational, cohort studies that had researched association between APOE ɛ4 and cognitive functions using systematic analysis method.The weight of evidence suggests that APOE ɛ4 is associated with cognitive functions in healthy adults. APOE ɛ4 carriers are likely to have lower level of cognitive functions. Associations between specific cognitive functions and APOE ɛ4 genotype are quit confusing. The most consistent finding was a negative relationship between APOE ɛ4 genotype and performance of memory and executive functioning. Presence of APOE ɛ4 and attention test results was less likely to be associated. Reasoning and verbal abilities were mostly not connected to APOE ɛ4 genotype. Associations between APOE ɛ4 and cognitive function differ in the groups of healthy adults, adults with mild cognitive impairment or Alzheimer disease. There were established that APOE ɛ4 is associated with cognitive functions in cognitively impaired population. People with mild cognitive impairment or Alzheimer disease more often tended to be APOE ɛ4 carriers in comparison with people who are not cognitively impaired. Longitudinal studies revealed different links between APOE ɛ4 and cognitive functions. Although APOE ɛ4 might be a risk factor of deterioration of cognitive functions in healthy and impaired cognitive functions groups. Yet prognostic value of APOE ɛ4 in deterioration of cognitive functions in Alzheimer population is confusing.The current review suggests that APOE ɛ4 has an effect on cognitive functions. It might be a risk factor for deterioration of cognitive functions in healthy adults and cognitively impaired population. However further researches are needed to establish specific associations between APOE ɛ4 genotype and different cognitive functions in healthy adults and disease populations.Keywords: cognitive functions, APOE ɛ4 genotype.

The Th1/E47cs-G apolipoprotein E (APOE) promoter allele is a risk factor for Alzheimer disease of very later onset

2002 ◽  
Vol 326 (3) ◽  
pp. 187-190 ◽  
Author(s):  
Katrin Beyer ◽  
José I. Lao ◽  
Milagros Gómez ◽  
Nadal Riutort ◽  
Pilar Latorre ◽  
...  
Keyword(s):  
Risk Factor ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Promoter Allele

scholarly journals Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 635
Author(s):  
Monica L. Hu ◽  
Joel Quinn ◽  
Kanmin Xue
Keyword(s):  
Risk Factor ◽  
Apolipoprotein E ◽  
Macular Degeneration ◽  
Amyloid Beta ◽  
Complement System ◽  
Genetic Risk ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Retinal Inflammation ◽  
The Complement System

Age-related macular degeneration (AMD) is a multifactorial retinal disorder that is a major global cause of severe visual impairment. The development of an effective therapy to treat geographic atrophy, the predominant form of AMD, remains elusive due to the incomplete understanding of its pathogenesis. Central to AMD diagnosis and pathology are the hallmark lipid and proteinaceous deposits, drusen and reticular pseudodrusen, that accumulate in the subretinal pigment epithelium and subretinal spaces, respectively. Age-related changes and environmental stressors, such as smoking and a high-fat diet, are believed to interact with the many genetic risk variants that have been identified in several major biochemical pathways, including lipoprotein metabolism and the complement system. The APOE gene, encoding apolipoprotein E (APOE), is a major genetic risk factor for AMD, with the APOE2 allele conferring increased risk and APOE4 conferring reduced risk, in comparison to the wildtype APOE3. Paradoxically, APOE4 is the main genetic risk factor in Alzheimer's disease, a disease with features of neuroinflammation and amyloid-beta deposition in common with AMD. The potential interactions of APOE with the complement system and amyloid-beta are discussed here to shed light on their roles in AMD pathogenesis, including in drusen biogenesis, immune cell activation and recruitment, and retinal inflammation.

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease

1995 ◽  
Vol 33 (1) ◽  
pp. 174-178 ◽  
Author(s):  
Philippe Bertrand ◽  
Judes Poirier ◽  
Tomiichiro Oda ◽  
Caleb E. Finch ◽  
Giulio Maria Pasinetti
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Brain Levels ◽  
Apolipoprotein J ◽  
Apolipoprotein E Genotype

Lack of Association of Apolipoprotein E ε4 Allele Dose with Cerebral Glucose Metabolism in Alzheimer Disease

1998 ◽  
Vol 12 (4) ◽  
pp. 362-367 ◽  
Author(s):  
Nobutsugu Hirono ◽  
Etsuro Mori ◽  
Minoru Yasuda ◽  
Kazunari Ishii ◽  
Yoshitaka Ikejiri ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Cerebral Glucose Metabolism ◽  
Ε4 Allele

scholarly journals Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 ◽  
Vol 91 (23) ◽  
pp. 11183-11186 ◽  
Author(s):  
W. J. Strittmatter ◽  
A. M. Saunders ◽  
M. Goedert ◽  
K. H. Weisgraber ◽  
L. M. Dong ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Specific Interactions ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau
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