scholarly journals Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses

2020 ◽  
Vol 204 (12) ◽  
pp. 3149-3159 ◽  
Author(s):  
Ricardo de Mendonça Vieira ◽  
Ava Meagher ◽  
Ângela C. Crespo ◽  
Sarika K. Kshirsagar ◽  
Vidya Iyer ◽  
...  
Keyword(s):  
Nk Cells ◽  
Term Pregnancy ◽  
Cytotoxic Responses

scholarly journals Classification of human natural killer cells based on migration behavior and cytotoxic response

Blood ◽  
2013 ◽  
Vol 121 (8) ◽  
pp. 1326-1334 ◽  
Author(s):  
Bruno Vanherberghen ◽  
Per E. Olofsson ◽  
Elin Forslund ◽  
Michal Sternberg-Simon ◽  
Mohammad Ali Khorshidi ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Serial Killer ◽  
Migration Behavior ◽  
Killer Cells ◽  
Key Points ◽  
Human Natural Killer Cells ◽  
Cytotoxic Responses

Key Points Activated NK cells display heterogeneity in their cytotoxic responses that justifies grouping them into 5 distinct classes of NK cells. A subpopulation of particularly active “serial killer” NK cells deliver their lytic hits faster and release more perforin in each hit.

scholarly journals Mirc11 Disrupts Inflammatory but Not Cytotoxic Responses of NK Cells

2019 ◽  
Vol 7 (10) ◽  
pp. 1647-1662 ◽  
Author(s):  
Arash Nanbakhsh ◽  
Anupallavi Srinivasamani ◽  
Sandra Holzhauer ◽  
Matthew J. Riese ◽  
Yongwei Zheng ◽  
...  
Keyword(s):  
Nk Cells ◽  
Cytotoxic Responses

scholarly journals HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts

Blood ◽  
2007 ◽  
Vol 110 (4) ◽  
pp. 1207-1214 ◽  
Author(s):  
Jeffrey Ward ◽  
Matthew Bonaparte ◽  
Jennifer Sacks ◽  
Jacqueline Guterman ◽  
Manuela Fogli ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Target Cells ◽  
Nk Cell Receptors ◽  
Infected Cells ◽  
Cytotoxic Responses

AbstractThe ability of natural killer (NK) cells to kill virus-infected cells depends on the presence of ligands for activation receptors on the target cells. We found the presence of few, if any, NKp30 and NK46 ligands on T cell blasts infected with HIV, although NKp44 ligands were found on infected cells. HIV does induce the NKG2D ligands ULBP-1, -2, and -3. These ligands are involved in triggering NK cells to kill autologous HIV-infected cells, because interfering with the interaction between NKG2D, but not NKp46, on NK cells and its ligands on HIV-infected cells drastically reduced the lysis of infected cells. Interfering with the binding of the NK-cell coreceptors NTB-A and 2B4 to their ligands also decreased destruction by NK cells. The coreceptor ligands, NTB-A and CD48, were also found to be down-regulated during the course of HIV infection. Thus, ligands for NK-cell receptors are modulated during the course of HIV infection, which may greatly alter NK cells' ability to kill the infected cells.

Differential distribution of NK cells in decidua basalis compared with decidua parietalis after uncomplicated human term pregnancy

2003 ◽  
Vol 64 (10) ◽  
pp. 921-929 ◽  
Author(s):  
Aliana P Sindram-Trujillo ◽  
Sicco A Scherjon ◽  
Paula P van Hulst-van Miert ◽  
Jolien J van Schip ◽  
Humphrey H.H Kanhai ◽  
...  
Keyword(s):  
Nk Cells ◽  
Term Pregnancy ◽  
Differential Distribution ◽  
Decidua Basalis

CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells

Blood ◽  
1999 ◽  
Vol 94 (11) ◽  
pp. 3864-3871 ◽  
Author(s):  
Giuseppe Sconocchia ◽  
Julie A. Titus ◽  
Alessandra Mazzoni ◽  
Alberto Visintin ◽  
Federica Pericle ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Adhesion Molecules ◽  
De Novo ◽  
Interleukin 2 ◽  
Innate Immune ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Lytic Function ◽  
Human Natural Killer Cells ◽  
Cytotoxic Responses

Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined, although it is now clear that a number of adhesion molecules can serve this function. CD38 transduces signals on T- and B-cell lines, and we asked whether it could trigger lytic and secretory responses in human NK cells. By using an anti-CD38 monoclonal antibody in reverse antibody-dependent cellular cytotoxicity experiments, it is shown that CD38 engagement triggers cytotoxic responses by activated NK cells, but not by cytotoxic T lymphocytes or fresh NK cells. Cross-linking with anti-CD38 F(ab′)2 caused activated NK cells to release granzymes and cytokines, but did not trigger an increase in intracellular Ca2+. Fresh NK cells acquired CD38-dependent lytic function during activation with interleukin-2 (IL-2), and inhibitor studies suggested that IL-2 stimulated the de novo expression of proteins that act between CD38 and the lytic machinery in NK cells. The induction of proteins that link commonly expressed adhesion molecules to effector mechanisms could provide a paradigm for pathogen recognition by the innate immune system.

Changes of natural cytotoxicity receptors in decidual NK cells at term pregnancy

2015 ◽  
Vol 111 ◽  
pp. 29
Author(s):  
H. Takahashi ◽  
T. Yamamoto ◽  
T. Matsuno ◽  
T. Murase ◽  
M. Yamazaki ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Cytotoxicity ◽  
Term Pregnancy ◽  
Natural Cytotoxicity Receptors

scholarly journals CD16 aggregation induced by therapeutic antibody-opsonised targets impairs cytotoxic responses in human NK cells

2013 ◽  
Vol 4 ◽  
Author(s):  
Capuano Cristina ◽  
Romanelli Maddalena ◽  
Pighi Chiara ◽  
Molfetta Rosa ◽  
Paolini Rossella ◽  
...  
Keyword(s):  
Nk Cells ◽  
Therapeutic Antibody ◽  
Cytotoxic Responses

CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells

Blood ◽  
1999 ◽  
Vol 94 (11) ◽  
pp. 3864-3871 ◽  
Author(s):  
Giuseppe Sconocchia ◽  
Julie A. Titus ◽  
Alessandra Mazzoni ◽  
Alberto Visintin ◽  
Federica Pericle ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Adhesion Molecules ◽  
De Novo ◽  
Interleukin 2 ◽  
Innate Immune ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Lytic Function ◽  
Human Natural Killer Cells ◽  
Cytotoxic Responses

Abstract Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined, although it is now clear that a number of adhesion molecules can serve this function. CD38 transduces signals on T- and B-cell lines, and we asked whether it could trigger lytic and secretory responses in human NK cells. By using an anti-CD38 monoclonal antibody in reverse antibody-dependent cellular cytotoxicity experiments, it is shown that CD38 engagement triggers cytotoxic responses by activated NK cells, but not by cytotoxic T lymphocytes or fresh NK cells. Cross-linking with anti-CD38 F(ab′)2 caused activated NK cells to release granzymes and cytokines, but did not trigger an increase in intracellular Ca2+. Fresh NK cells acquired CD38-dependent lytic function during activation with interleukin-2 (IL-2), and inhibitor studies suggested that IL-2 stimulated the de novo expression of proteins that act between CD38 and the lytic machinery in NK cells. The induction of proteins that link commonly expressed adhesion molecules to effector mechanisms could provide a paradigm for pathogen recognition by the innate immune system.

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