scholarly journals Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth

2019 ◽  
Vol 203 (7) ◽  
pp. 1793-1807 ◽  
Author(s):  
Nardhy Gomez-Lopez ◽  
Roberto Romero ◽  
Yi Xu ◽  
Derek Miller ◽  
Marcia Arenas-Hernandez ◽  
...  
Keyword(s):  
Preterm Birth ◽  
T Cell ◽  
T Cell Activation ◽  
Preterm Labor ◽  
Cell Activation ◽  
Potential Mechanism ◽  
Amniotic Cavity

scholarly journals In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth

2016 ◽  
Vol 76 (5) ◽  
pp. 386-390 ◽  
Author(s):  
Nardhy Gomez-Lopez ◽  
Roberto Romero ◽  
Marcia Arenas-Hernandez ◽  
Hyunyoung Ahn ◽  
Bogdan Panaitescu ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Preterm Labor ◽  
Cell Activation

scholarly journals Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege

2014 ◽  
Vol 134 (3) ◽  
pp. 736-745 ◽  
Author(s):  
Xiaojie Wang ◽  
Alexandra K. Marr ◽  
Trisia Breitkopf ◽  
Gigi Leung ◽  
Jianqiang Hao ◽  
...  
Keyword(s):  
T Cell ◽  
Hair Follicle ◽  
T Cell Activation ◽  
Cell Activation ◽  
Immune Privilege ◽  
Potential Mechanism ◽  
Induced Apoptosis

scholarly journals Preterm Labor and Chorioamnionitis Are Associated with Neonatal T Cell Activation

PLoS ONE ◽  
2011 ◽  
Vol 6 (2) ◽  
pp. e16698 ◽  
Author(s):  
Angel A. Luciano ◽  
Haiyan Yu ◽  
Leila W. Jackson ◽  
Lisa A. Wolfe ◽  
Helene B. Bernstein
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Preterm Labor ◽  
Cell Activation

scholarly journals Integrative analysis of transcriptomic data for identification of T-cell activation-related mRNA signatures indicative of preterm birth

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae Young Yoo ◽  
Do Young Hyeon ◽  
Yourae Shin ◽  
Soo Min Kim ◽  
Young-Ah You ◽  
...  
Keyword(s):  
Preterm Birth ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Sequencing Analysis ◽  
Mortality And Morbidity ◽  
Activation Pathway ◽  
The Core

AbstractPreterm birth (PTB), defined as birth at less than 37 weeks of gestation, is a major determinant of neonatal mortality and morbidity. Early diagnosis of PTB risk followed by protective interventions are essential to reduce adverse neonatal outcomes. However, due to the redundant nature of the clinical conditions with other diseases, PTB-associated clinical parameters are poor predictors of PTB. To identify molecular signatures predictive of PTB with high accuracy, we performed mRNA sequencing analysis of PTB patients and full-term birth (FTB) controls in Korean population and identified differentially expressed genes (DEGs) as well as cellular pathways represented by the DEGs between PTB and FTB. By integrating the gene expression profiles of different ethnic groups from previous studies, we identified the core T-cell activation pathway associated with PTB, which was shared among all previous datasets, and selected three representative DEGs (CYLD, TFRC, and RIPK2) from the core pathway as mRNA signatures predictive of PTB. We confirmed the dysregulation of the candidate predictors and the core T-cell activation pathway in an independent cohort. Our results suggest that CYLD, TFRC, and RIPK2 are potentially reliable predictors for PTB.

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