scholarly journals Skin Wounding–Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency

2019 ◽  
Vol 202 (9) ◽  
pp. 2720-2727 ◽  
Author(s):  
Pijus K. Barman ◽  
Jingbo Pang ◽  
Norifumi Urao ◽  
Timothy J. Koh
Keyword(s):  
Skin Wounding

Ephrin-A4 inhibits sensory neurite outgrowth and is regulated by neonatal skin wounding

2005 ◽  
Vol 22 (10) ◽  
pp. 2413-2421 ◽  
Author(s):  
Andrew Moss ◽  
Debie Alvares ◽  
Jacqueta Meredith-Middleton ◽  
Michelle Robinson ◽  
Rebeccah Slater ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Neonatal Skin ◽  
Skin Wounding

Survival and endogenous spleen colonies of irradiated mice after skin wounding and hydroxyurea treatment

1982 ◽  
Vol 38 (10) ◽  
pp. 1228-1230 ◽  
Author(s):  
G. D. Ledney ◽  
H. M. Gelston ◽  
S. R. Weinberg ◽  
E. D. Exum
Keyword(s):  
Hydroxyurea Treatment ◽  
Endogenous Spleen Colonies ◽  
Skin Wounding

scholarly journals A Pilot Evaluation of Scalp Skin Wounding to Promote Hair Growth in Female Pattern Hair Loss

2020 ◽  
Author(s):  
Laura J. Burns ◽  
Dina Hagigeorges ◽  
Kelly E. Flanagan ◽  
James Pathoulas ◽  
Maryanne M. Senna
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Female Pattern Hair Loss ◽  
Scalp Skin ◽  
Skin Wounding

scholarly journals 957 Local skin wounding reduces systemic antibody-mediated neutrophil depletion

2019 ◽  
Vol 139 (5) ◽  
pp. S165
Author(s):  
E.M. Wier ◽  
B. Pielstick ◽  
C. Hintelmann ◽  
N. Archer ◽  
R. Ortines ◽  
...  
Keyword(s):  
Local Skin ◽  
Neutrophil Depletion ◽  
Skin Wounding

C57BL/6 mice are resistant to tumor promotion by full thickness skin wounding

1993 ◽  
Vol 14 (2) ◽  
pp. 319-321 ◽  
Author(s):  
J. DiGiovanni ◽  
T. S.Bhatt ◽  
S. E.Walker
Keyword(s):  
Tumor Promotion ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Skin Wounding

scholarly journals Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding

2009 ◽  
Vol 4 (2) ◽  
pp. 205-223 ◽  
Author(s):  
Gautam S Ghatnekar ◽  
Michael P O’Quinn ◽  
L Jane Jourdan ◽  
Abhijit A Gurjarpadhye ◽  
Robert L Draughn ◽  
...  
Keyword(s):  
Carboxyl Terminal ◽  
Skin Wounding

scholarly journals Transcriptomic Insights on the Preventive Action of Apple (cv Granny Smith) Skin Wounding on Superficial Scald Development

2021 ◽  
Vol 22 (24) ◽  
pp. 13425
Author(s):  
Nadia Cainelli ◽  
Cristian Forestan ◽  
Dario Angeli ◽  
Tomas Villegas ◽  
Fabrizio Costa ◽  
...  
Keyword(s):  
Time Course ◽  
Mechanistic Explanation ◽  
Rna Seq ◽  
Preventive Action ◽  
Superficial Scald ◽  
Post Harvest ◽  
Local Inhibition ◽  
Transcriptional Changes ◽  
Skin Wounding ◽  
Preventive Role

Superficial scald is a post-harvest chilling storage injury leading to browning of the surface of the susceptible cv Granny Smith apples. Wounding of skins has been reported to play a preventive role on scald development however its underlying molecular factors are unknown. We have artificially wounded the epidermal and sub-epidermal layers of apple skins consistently obtaining the prevention of superficial scald in the surroundings of the wounds during two independent vintages. Time course RNA-Seq analyses of the transcriptional changes in wounded versus unwounded skins revealed that two transcriptional waves occurred. An early wave included genes up-regulated by wounding already after 6 h, highlighting a specific transcriptional rearrangement of genes connected to the biosynthesis and signalling of JA, ethylene and ABA. A later transcriptional wave, occurring after three months of cold storage, included genes up-regulated exclusively in unwounded skins and was prevented from its occurrence in wounded skins. A significant portion of these genes was related to decay of tissues and to the senescence hormones ABA, JA and ethylene. Such changes suggest a wound-inducible reversed hormonal balance during post-harvest storage which may explain the local inhibition of scald in wounded tissues, an aspect that will need further studies for its mechanistic explanation.

scholarly journals Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

2020 ◽  
Vol 6 (12) ◽  
pp. eaay3704 ◽  
Author(s):  
Denise Gay ◽  
Giulia Ghinatti ◽  
Christian F. Guerrero-Juarez ◽  
Rubén A. Ferrer ◽  
Federica Ferri ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Wound Repair ◽  
Skin Condition ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Single Cell Rna Sequencing ◽  
Wnt Inhibitor ◽  
Skin Healing ◽  
Skin Wounding ◽  
Regenerative Repair

Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN wounds, increased expression of phagocytic/lysosomal genes in macrophages associated with predominance of fibrotic myofibroblasts in fibrotic wounds. Investigation revealed that macrophages in the late wound drive fibrosis by phagocytizing dermal Wnt inhibitor SFRP4 to establish persistent Wnt activity. In accordance, phagocytosis abrogation resulted in transient Wnt activity and a more regenerative healing. Phagocytosis of SFRP4 was integrin-mediated and dependent on the interaction of SFRP4 with the EDA splice variant of fibronectin. In the human skin condition hidradenitis suppurativa, phagocytosis of SFRP4 by macrophages correlated with fibrotic wound repair. These results reveal that macrophages can modulate a key signaling pathway via phagocytosis to alter the skin wound healing fate.

scholarly journals 814 Circadian factors BMAL1 and CLOCK control transcriptional innate antiviral immunity programs in response to skin wounding

2020 ◽  
Vol 140 (7) ◽  
pp. S107
Author(s):  
S. Kirchner ◽  
V. Lei ◽  
M. Coates ◽  
C. Handfield ◽  
D. Corcoran ◽  
...  
Keyword(s):  
Antiviral Immunity ◽  
Innate Antiviral Immunity ◽  
Skin Wounding

scholarly journals Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block

1999 ◽  
Vol 83 (4) ◽  
pp. 662-664 ◽  
Author(s):  
J De Lima ◽  
D Alvares ◽  
D J Hatch ◽  
M Fitzgerald
Keyword(s):  
Sciatic Nerve ◽  
Nerve Block ◽  
Sciatic Nerve Block ◽  
Neonatal Skin ◽  
Skin Wounding
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