scholarly journals Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes

2019 ◽  
Vol 202 (7) ◽  
pp. 2057-2068
Author(s):  
Qinglai Meng ◽  
Asifa K. Zaidi ◽  
John Sedy ◽  
Armand Bensussan ◽  
Daniel L. Popkin
Keyword(s):  
Nk Cells ◽  
Cross Talk ◽  
Herpes Virus ◽  
Virus Entry ◽  
Herpes Virus Entry Mediator ◽  
Herpès Virus

scholarly journals TMIC-38. CLINICAL AND IMMUNOLOGICAL CHARACTERIZATION OF HERPES VIRUS ENTRY MEDIATOR IN HUMAN GLIOMAS

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi256-vi256
Author(s):  
Ming-Zhi Han ◽  
Shuai Wang ◽  
Dong-Hai Wang
Keyword(s):  
Immune Checkpoint ◽  
Herpes Virus ◽  
Cox Regression ◽  
Virus Entry ◽  
Immune Checkpoints ◽  
Cell Mediated Immunity ◽  
Human Gliomas ◽  
Genomic Databases ◽  
Herpes Virus Entry Mediator ◽  
Herpès Virus

Abstract BACKGROUND Dysregulation of immune checkpoint members within tumors, including glioblastoma (GBM), is related to immune evasion. Herpes virus entry mediator (HVEM) is a novel identified immune checkpoint molecule which plays essential roles in both innate and acquired immunity. Despite recent advances in exploring the function HVEM in a variety cancer types, the clinical and immunological importance of HVEM in human gliomas remain largely unknown. METHODS Molecular and clinical data was obtained from publicly genomic databases. Immunohistochemistry was applied to assess the protein level of HVEM. Matlab software as well as R language were used for statistical analysis. RESULTS HVEM was found to be elevated in aggressive gliomas, especially in isocitrate dehydrogenase (IDH) wild-type GBM. High expression of HVEM was associated with Mesenchymal subtype and showed promising prognostic values based on Cox regression model and nomogram model. HVEM showed intra-tumor heterogeneity with abundant in peri-necrotic zone and microvascular region. In addition, HVEM high patients were more frequent with genomic aberrations of oncogenic events. Gene ontology and pathway analysis uncovered the enrichment of HVEM in multiple immune regulation process, especially in the suppression of T cell mediated immunity in GBM. Moreover, HVEM was tightly associated with several infiltrating immune and stromal cell lineages in microenvironment, and showed high correlation with other immune checkpoints. CONCLUSIONS Our data highlights the importance of HVEM in GBM progression and that targeting HVEM combined with current immune checkpoint blockades might be a novel therapeutic strategy for GBM.

Expression and Clinical Significance of Herpes Virus Entry Mediator (HVEM) in Breast Cancer

2017 ◽  
Vol 24 (13) ◽  
pp. 4042-4050 ◽  
Author(s):  
Julia Y. S. Tsang ◽  
Kit-Wing Chan ◽  
Yun-Bi Ni ◽  
Thazin Hlaing ◽  
Jintao Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Significance ◽  
Herpes Virus ◽  
Virus Entry ◽  
Herpes Virus Entry Mediator ◽  
Herpès Virus

scholarly journals Absence of Herpes Virus Entry Mediator (HVEM) Increases Bone Mass by Attenuating Receptor Activator of Nuclear Factor-κB ligand (RANKL)-Induced Osteoclastogenesis

Endocrinology ◽  
2012 ◽  
Vol 153 (10) ◽  
pp. 4808-4817 ◽  
Author(s):  
Woon-Ki Kim ◽  
Ok-Joo Sul ◽  
Eun-Kyung Choi ◽  
Mi-Hyun Lee ◽  
Choon-Soo Jeong ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Mass ◽  
Knockout Mice ◽  
Herpes Virus ◽  
Virus Entry ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Herpes Virus Entry Mediator ◽  
Receptor Activator ◽  
Herpès Virus

Abstract Herpes virus entry mediator (HVEM), which is constitutively expressed at a high level on myeloid lineage cells, is also expressed on bone marrow-derived macrophages, suggesting that it may play a role in bone metabolism by affecting osteoclasts (OC) derived from bone marrow-derived macrophages. To address this question, we evaluated bone mass by micro-computed tomography and the number and activity of OC by tartrate-resistant acid phosphatase (TRAP) and pit formation on dentine slices, comparing HVEM-knockout mice with wild-type mice. The absence of HVEM led to a higher bone mass and to decreased levels of serum collagen type I fragments and serum TRACP5b in vivo. In vitro HVEM deficiency resulted in a reduced number and activity of OC and an impaired receptor activator of nuclear factor-κB ligand signaling through reduced activation of nuclear factor-κB and of nuclear factor of activated T-cells cytoplasmic 1. Exogenous soluble HVEM decreased expression of TRAP, whereas soluble LIGHT (a ligand of HVEM) increased it, indicating the occurrence of a positive signaling through HVEM during osteoclastogenesis. Our findings indicate that HVEM regulates bone remodeling via action on OC. The higher bone mass in the femurs of HVEM-knockout mice could be, at least in part, due to attenuated osteoclastogenesis and bone resorption resulting from decreased receptor activator of nuclear factor-κB ligand signaling in the OC.

scholarly journals High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases

2003 ◽  
Vol 35 (6) ◽  
pp. 501-508 ◽  
Author(s):  
Hyo Won Jung ◽  
Su Jin La ◽  
Ji Young Kim ◽  
Suk Kyeung Heo ◽  
Ju Yang Kim ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Herpes Virus ◽  
Virus Entry ◽  
Herpes Virus Entry Mediator ◽  
Herpès Virus

The paradoxical changes of membrane and soluble herpes virus entry mediator in hepatocellular carcinoma patients

2017 ◽  
Vol 32 (8) ◽  
pp. 1520-1524 ◽  
Author(s):  
Qiyi Zhao ◽  
Geng-lin Zhang ◽  
Xiang Zhu ◽  
Di Su ◽  
Zhan-Lian Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Herpes Virus ◽  
Virus Entry ◽  
Herpes Virus Entry Mediator ◽  
Herpès Virus
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