scholarly journals Cutting Edge: ROR1/CD19 Receptor Complex Promotes Growth of Mantle Cell Lymphoma Cells Independently of the B Cell Receptor–BTK Signaling Pathway

2019 ◽  
Vol 203 (8) ◽  
pp. 2043-2048 ◽  
Author(s):  
Qian Zhang ◽  
Hong Y. Wang ◽  
Xiaobin Liu ◽  
Selene Nunez-Cruz ◽  
Mowafaq Jillab ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Signaling Pathway ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Cutting Edge ◽  
Receptor Complex ◽  
Lymphoma Cells ◽  
Mantle Cell

scholarly journals The B-cell Receptor Autoantigen LRPAP1 Can Replace Variable Antibody Regions to Target Mantle Cell Lymphoma Cells

HemaSphere ◽  
2021 ◽  
Vol 5 (8) ◽  
pp. e620
Author(s):  
Moritz Bewarder ◽  
Maximilian Kiefer ◽  
Helene Will ◽  
Kathrin Olesch ◽  
Clara Moelle ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Lymphoma Cells ◽  
Mantle Cell

scholarly journals Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1143 ◽  
Author(s):  
Laia Sadeghi ◽  
Gustav Arvidsson ◽  
Magali Merrien ◽  
Agata M. Wasik ◽  
André Görgens ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Stromal Cells ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Model Framework ◽  
Lymphoma Cells ◽  
Mantle Cell

Interactions between lymphoma cells and stromal cells play a key role in promoting tumor survival and development of drug resistance. We identified differences in key signaling pathways between the JeKo-1 and REC-1 mantle cell lymphoma (MCL) cell lines, displaying different patterns of stromal cell adhesion and chemotaxis towards stroma-conditioned medium. The identified adhesion-regulated genes reciprocated important aspects of microenvironment-mediated gene modulation in MCL patients. Five-hundred and ninety genes were differently regulated between the cell lines upon adhesion to stromal cells, while 32 genes were similarly regulated in both cell lines. Regulation of B-cell Receptor (BCR) signature genes in adherent cells was specific for JeKo-1. Inhibition of BCR using siRNA or clinically approved inhibitors, Ibrutinib and Acalabrutinib, decreased adhesion of JeKo-1, but not REC-1 cells. Cell surface levels of chemokine receptor CXCR4 were higher in JeKo-1, facilitating migration and adhesion of JeKo-1 but not REC-1 cells. Surface levels of ICAM1 adhesion protein differ for REC-1 and JeKo-1. While ICAM1 played a positive role in adherence of both cell lines to stromal cells, S1PR1 had an inhibitory effect. Our results provide a model framework for further investigation of mechanistic differences in patient-response to new pathway-specific drugs.

scholarly journals Differential B-cell receptor signaling requirement for adhesion of mantle cell lymphoma cells to stromal cells

2020 ◽  
Author(s):  
Laia Sadeghi ◽  
Gustav Arvidsson ◽  
Magali Merrien ◽  
Agata M. Wasik ◽  
André Görgens ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Stromal Cells ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Model Framework ◽  
Lymphoma Cells ◽  
Mantle Cell

AbstractInteractions between lymphoma cells and stromal cells play a key role in promoting tumor survival and development of drug resistance. We identified differences in key signaling pathways between the JeKo-1 and REC-1 mantle cell lymphoma (MCL) cell lines, which exhibited different patterns of stromal cell adhesion and chemotactic migration towards stroma-conditioned medium. The identified adhesion-regulated genes reciprocated important aspects of microenvironment-mediated gene modulation in MCL patients. 590 genes were differently regulated between the cell lines upon adhesion to stromal cells, while 32 genes were similarly regulated in both cell lines. Regulation of B-cell Receptor (BCR) signature genes in adherent cells was specific for JeKo-1. Inhibition of BCR signaling by siRNA or clinically approved inhibitors, Ibrutinib and Acalabrutinib, decreased adhesion of JeKo-1 but not REC-1 cells to stromal cells. Cell surface levels of CXCR4 were higher in JeKo-1 cells and CXCR4 was important for migration and adhesion of JeKo-1 but not REC-1 cells. Surface levels of ICAM1 adhesion protein differ for REC-1 and JeKo-1. While ICAM1 plays a positive role in adherence of both cell lines to stromal cells, S1PR1 had an inhibitory effect. The results presented here provide a model framework for further investigation of mechanistic differences in patient-response to new pathway-specific drugs.

scholarly journals The B cell receptor signaling pathway in mantle cell lymphoma

Oncotarget ◽  
2018 ◽  
Vol 9 (38) ◽  
pp. 25332-25341 ◽  
Author(s):  
Maria I. Merolle ◽  
Makhdum Ahmed ◽  
Krystle Nomie ◽  
Michael L. Wang
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Signaling Pathway ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell ◽  
Receptor Signaling Pathway ◽  
B Cell Receptor Signaling ◽  
Cell Receptor Signaling

Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma

Oncogene ◽  
2020 ◽  
Vol 39 (14) ◽  
pp. 2934-2947
Author(s):  
Gregory Lazarian ◽  
Chloe Friedrich ◽  
Anne Quinquenel ◽  
Julie Tran ◽  
Souhail Ouriemmi ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Target Genes ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Receptor Signaling ◽  
Mantle Cell ◽  
B Cell Receptor Signaling ◽  
Cell Receptor Signaling

scholarly journals Constitutive and B-cell receptor-induced activation of STAT3 are important signaling pathways targeted by bortezomib in leukemic mantle cell lymphoma

Haematologica ◽  
2010 ◽  
Vol 95 (11) ◽  
pp. 1865-1872 ◽  
Author(s):  
F. Baran-Marszak ◽  
M. Boukhiar ◽  
S. Harel ◽  
C. Laguillier ◽  
C. Roger ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Signaling Pathways ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell

scholarly journals Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling

2011 ◽  
Vol 34 (2) ◽  
pp. 141-153 ◽  
Author(s):  
Chiara Pighi ◽  
Ting-Lei Gu ◽  
Irene Dalai ◽  
Stefano Barbi ◽  
Claudia Parolini ◽  
...  
Keyword(s):  
B Cell ◽  
Mantle Cell Lymphoma ◽  
Proteomic Analysis ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Mantle Cell ◽  
B Cell Receptor Signaling ◽  
Cell Receptor Signaling
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