scholarly journals Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal

2018 ◽  
Vol 202 (3) ◽  
pp. 736-746 ◽  
Author(s):  
Benedikt Jacobs ◽  
Aline Pfefferle ◽  
Dennis Clement ◽  
Axel Berg-Larsen ◽  
Michelle L. Saetersmoen ◽  
...  
Keyword(s):  
Nk Cells ◽  
Splice Variant ◽  
Short Splice Variant

Scaffold protein enigma homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes

2015 ◽  
Vol 27 (12) ◽  
pp. 2425-2433 ◽  
Author(s):  
Jumpei Ito ◽  
Masumi Iijima ◽  
Nobuo Yoshimoto ◽  
Tomoaki Niimi ◽  
Shun’ichi Kuroda ◽  
...  
Keyword(s):  
Splice Variant ◽  
Scaffold Protein ◽  
Creb Activation ◽  
Short Splice Variant

scholarly journals Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia

2019 ◽  
Vol 46 (3) ◽  
pp. 690-698
Author(s):  
Cassidy L Moody ◽  
Adam J Funk ◽  
Emily Devine ◽  
Ryan C Devore Homan ◽  
Detlev Boison ◽  
...  
Keyword(s):  
Protein Expression ◽  
Frontal Cortex ◽  
Splice Variant ◽  
Adenosine Kinase ◽  
Anterior Cingulate ◽  
Gene And Protein Expression ◽  
Significant Difference ◽  
Dorsolateral Prefrontal ◽  
Kinase Expression ◽  
Short Splice Variant

Abstract The adenosine hypothesis of schizophrenia posits that reduced availability of the neuromodulator adenosine contributes to dysregulation of dopamine and glutamate transmission and the symptoms associated with schizophrenia. It has been proposed that increased expression of the enzyme adenosine kinase (ADK) may drive hypofunction of the adenosine system. While animal models of ADK overexpression support such a role for altered ADK, the expression of ADK in schizophrenia has yet to be examined. In this study, we assayed ADK gene and protein expression in frontocortical tissue from schizophrenia subjects. In the dorsolateral prefrontal cortex (DLPFC), ADK-long and -short splice variant expression was not significantly altered in schizophrenia compared to controls. There was also no significant difference in ADK splice variant expression in the frontal cortex of rats treated chronically with haloperidol-decanoate, in a study to identify the effect of antipsychotics on ADK gene expression. ADK protein expression was not significantly altered in the DLPFC or anterior cingulate cortex (ACC). There was no significant effect of antipsychotic medication on ADK protein expression in the DLPFC or ACC. Overall, our results suggest that increased ADK expression does not contribute to hypofunction of the adenosine system in schizophrenia and that alternative mechanisms are involved in dysregulation of this system in schizophrenia.

scholarly journals The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36412 ◽  
Author(s):  
Li Peng ◽  
Michael D. Oberst ◽  
Jiaqi Huang ◽  
Philip Brohawn ◽  
Chris Morehouse ◽  
...  
Keyword(s):  
Splice Variant ◽  
Bispecific Antibody ◽  
Full Length ◽  
Short Splice Variant

scholarly journals BECN1s, a short splice variant of BECN1, functions in mitophagy

Autophagy ◽  
2015 ◽  
Vol 11 (11) ◽  
pp. 2048-2056 ◽  
Author(s):  
Bing Cheng ◽  
An Xu ◽  
Mengran Qiao ◽  
Qiao Wu ◽  
Wenyu Wang ◽  
...  
Keyword(s):  
Splice Variant ◽  
Short Splice Variant

scholarly journals Genetic Analysis of the Short Splice Variant of the Inhibitor of Caspase-activated DNase (ICAD-S) in Chicken DT40 Cells

2007 ◽  
Vol 282 (37) ◽  
pp. 27374-27382 ◽  
Author(s):  
Alexander V. Ageichik ◽  
Kumiko Samejima ◽  
Scott H. Kaufmann ◽  
William C. Earnshaw
Keyword(s):  
Genetic Analysis ◽  
Splice Variant ◽  
Caspase Activated Dnase ◽  
Dt40 Cells ◽  
Short Splice Variant
Sign in / Sign up

Export Citation Format

Share Document