scholarly journals Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer

2019 ◽  
Vol 202 (12) ◽  
pp. 3458-3467 ◽  
Author(s):  
Vid Leko ◽  
Lucas A. McDuffie ◽  
Zhili Zheng ◽  
Jared J. Gartner ◽  
Todd D. Prickett ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Primary Bladder ◽  
Infiltrating Lymphocytes ◽  
Primary Bladder Cancer

scholarly journals Gender Differences in Pathologic Outcomes At Primary Bladder Cancer Detection

2015 ◽  
Author(s):  
Rahmi Gökhan Ekin ◽  
Zübeyde Yıldırım Ekin ◽  
Gökhan Koç ◽  
Ayşe Gülden Diniz Ünlü ◽  
Yusuf Özlem İlbey ◽  
...  
Keyword(s):  
Gender Differences ◽  
Bladder Cancer ◽  
Cancer Detection ◽  
Primary Bladder ◽  
Primary Bladder Cancer

scholarly journals PELVIC LYMPH NODE INVOLVEMENT IN PRIMARY BLADDER CANCER

1995 ◽  
Vol 86 (4) ◽  
pp. 919-926 ◽  
Author(s):  
Osamu Kuriki ◽  
Yoshinari Ono ◽  
Norio Katoh ◽  
Masafumi Sahashi ◽  
Tsuneo Kinukawa ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Pelvic Lymph Node ◽  
Node Involvement ◽  
Primary Bladder ◽  
Pelvic Lymph Node Involvement ◽  
Primary Bladder Cancer

scholarly journals Preoperative Glasgow prognostic score as a predictor of primary bladder cancer recurrence

2016 ◽  
Vol 5 (1) ◽  
pp. 201-206 ◽  
Author(s):  
OZGUR HAKI YUKSEL ◽  
SERKAN AKAN ◽  
AHMET URKMEZ ◽  
CAGLAR YILDIRIM ◽  
AYTAC SAHIN ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Cancer Recurrence ◽  
Primary Bladder ◽  
Bladder Cancer Recurrence ◽  
Primary Bladder Cancer

scholarly journals Spatial heterogeneity and organization of tumor mutation burden and immune infiltrates within tumors based on whole slide images correlated with patient survival in bladder cancer

2019 ◽  
Author(s):  
Hongming Xu ◽  
Sunho Park ◽  
Jean René Clemenceau ◽  
Jinhwan Choi ◽  
Nathan Radakovich ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Spatial Heterogeneity ◽  
Tumor Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
The Cancer Genome Atlas ◽  
Mutation Burden ◽  
Prognostic Utility ◽  
Cancer Genome Atlas ◽  
Infiltrating Lymphocytes ◽  
Whole Slide Images

AbstractHigh-TMB (TMB-H) could result in an increased number of neoepitopes from somatic mutations expressed by a patient’s own tumor cell which can be recognized and targeted by neighboring tumor-infiltrating lymphocytes (TILs). Deeper understanding of spatial heterogeneity and organization of tumor cells and their neighboring immune infiltrates within tumors could provide new insights into tumor progression and treatment response. Here we developed and applied computational approaches using digital whole slide images (WSIs) to investigate spatial heterogeneity and organization of regions harboring TMB-H tumor cells and TILs within tumors, and its prognostic utility. In experiments using WSIs from The Cancer Genome Atlas bladder cancer (BLCA), our findings show that WSI-based approaches can reliably predict patient-level TMB status and delineate spatial TMB heterogeneity and co-organization with TILs. TMB-H patients with low spatial heterogeneity enriched with high TILs show improved overall survival indicating a prognostic role of spatial TMB and TILs information in BLCA.

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