scholarly journals Local Attachment Explains Small World–like Properties of Fibroblastic Reticular Cell Networks in Lymph Nodes

2019 ◽  
Vol 202 (11) ◽  
pp. 3318-3325 ◽  
Author(s):  
Kasper M. W. Soekarjo ◽  
Johannes Textor ◽  
Rob J. de Boer
Keyword(s):  
Lymph Nodes ◽  
Small World ◽  
Reticular Cell ◽  
Fibroblastic Reticular Cell ◽  
Cell Networks

scholarly journals Local Attachment Explains Small-World-Like Properties of Fibroblastic Reticular Cell Networks in Lymph Nodes

2018 ◽  
Author(s):  
Kasper M.W. Soekarjo ◽  
Johannes Textor ◽  
Rob J. de Boer
Keyword(s):  
Lymph Nodes ◽  
Preferential Attachment ◽  
Small World ◽  
Network Size ◽  
Reticular Cell ◽  
Lymphocyte Migration ◽  
Fibroblastic Reticular Cell ◽  
Reticular Cells ◽  
2D And 3D ◽  
Cell Networks

AbstractFibroblastic reticular cells (FRCs) form a cellular network that serves as the structural backbone of lymph nodes and facilitates lymphocyte migration. This FRC network has been found to have small-world properties. Using a model based on geographical preferential attachment, we simulated the formation of a variety of cellular networks and show that similar small-world properties robustly emerge under such natural conditions. By estimating the parameters of this model, we generated FRC network representations with realistic topological properties. We found that these properties change markedly when the network is expanded from a thin slice to a 3D cube. Typical small-world properties were found to persist as network size was increased. The simulated networks were very similar to 2D and 3D lattice networks. According to the used metrics, these lattice networks also have small-world properties, indicating that lattice-likeness is sufficient to become classified as a small-world network. Our results explain why FRC networks have small-world properties and provide a framework for simulating realistic FRC networks.

scholarly journals Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

PLoS Biology ◽  
2016 ◽  
Vol 14 (7) ◽  
pp. e1002515 ◽  
Author(s):  
Mario Novkovic ◽  
Lucas Onder ◽  
Jovana Cupovic ◽  
Jun Abe ◽  
David Bomze ◽  
...  
Keyword(s):  
Lymph Node ◽  
Small World ◽  
Reticular Cell ◽  
Cell Network ◽  
Fibroblastic Reticular Cell ◽  
World Organization

scholarly journals Development of follicular dendritic cells in lymph nodes depends on retinoic acid mediated signaling

2020 ◽  
Author(s):  
Jasper J. Koning ◽  
Anusha Rajaraman ◽  
Rogier M. Reijmers ◽  
Tanja Konijn ◽  
Junliang Pan ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Lymph Nodes ◽  
Retinoic Acid Receptor ◽  
Follicular Dendritic Cell ◽  
Reticular Cell ◽  
Lineage Differentiation ◽  
Common Precursor ◽  
Fibroblastic Reticular Cell ◽  
Selective Generation ◽  
Follicular Dendritic

AbstractSpecialized stromal cells occupy and help define B- and T cell domains, which is crucial for proper functioning of our immune system. Signaling through lymphotoxin and TNF-receptors is crucial for development of different stromal subsets which are thought to arise from a common precursor. However, mechanisms that control the selective generation of the different stromal phenotypes are not known.Here we show that in mice, retinoic acid mediated signaling is important for the differentiation of precursors towards the Cxcl13pos follicular dendritic cell (FDC) lineage, while blocking lymphotoxin mediated Ccl19pos fibroblastic reticular cell (FRC) lineage differentiation. Consequently, we see at day of birth Cxcl13posCcl19neg/low and Cxcl13neg/lowCcl19pos cells within neonatal lymph nodes.Furthermore, ablation of retinoic acid receptor signaling in stromal precursors early after birth reduces Cxcl13 expression, while in addition, complete blockade of retinoic acid signaling prevents formation of FDC networks in lymph nodes.

scholarly journals Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity

2021 ◽  
Vol 22 (4) ◽  
pp. 510-519
Author(s):  
Alejandro Prados ◽  
Lucas Onder ◽  
Hung-Wei Cheng ◽  
Urs Mörbe ◽  
Mechthild Lütge ◽  
...  
Keyword(s):  
Cell Lineage ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Reticular Cell ◽  
Intestinal Immunity ◽  
Fibroblastic Reticular Cell

IL-17–dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10–producing B cells

2021 ◽  
Vol 6 (66) ◽  
Author(s):  
Dongwen Wu ◽  
Catherine H. Poholek ◽  
Saikat Majumder ◽  
Qixing Liu ◽  
Shankar K. Revu ◽  
...  
Keyword(s):  
B Cells ◽  
Mucosal Immunity ◽  
Reticular Cell ◽  
Fibroblastic Reticular Cell

Spontaneous Malignant Lymphoma in a New-World Primate

1974 ◽  
Vol 11 (1) ◽  
pp. 52-59 ◽  
Author(s):  
R. C. Page ◽  
L. Schectman ◽  
W. F. Ammons ◽  
L. Dillingham
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
New World ◽  
Reticulum Cell ◽  
Reticular Cell ◽  
Cell Type ◽  
Saguinus Oedipus ◽  
World Primate ◽  
Perivascular Infiltration

A spontaneous hematopoietic neoplasm in a cotton-top marmoset (Saguinus oedipus) was characterized by perivascular infiltration and invasion of the liver, kidneys, adrenals, spleen, lymph nodes, bone marrow, and lungs by a pleomorphic primitive reticular cell. A significant fraction of the circulating white cells was of the same cell type. The disease was diagnosed as lymphosarcoma of the reticulum-cell type with features similar to viral-induced malignancy previously described.

scholarly journals Metastatic Inflammatory Myofibroblastic Tumor of the Spleen: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Luca Koechlin ◽  
Andreas Zettl ◽  
Dieter Koeberle ◽  
Markus von Flüe ◽  
Martin Bolli
Keyword(s):  
Hepatic Metastasis ◽  
Spindle Cell ◽  
R0 Resection ◽  
Reticular Cell ◽  
Spindle Cell Neoplasm ◽  
Fibroblastic Reticular Cell ◽  
Cell Neoplasm ◽  
Inflammatory Myofibroblastic Tumors ◽  
Upper Abdomen ◽  
And Behavior

Introduction. Inflammatory myofibroblastic tumors (IMT) of the spleen are rare neoplasms and only little is known about the origin and behavior of these tumors. Here we report the case of a 37-year-old woman with an atypical spindle cell neoplasm showing features strongly suggesting an IMT of the spleen with hepatic metastasis. Methods. A 37-year-old patient had been complaining about pain in the left upper abdomen for the last two months. A CT scan revealed a tumor mass in her spleen and liver. After complete staging, a splenectomy and atypical liver resection of segments VII and VIII were performed. Literature was screened for similar cases and existing further literature. Results. A R0 resection was achieved. Histological analysis showed a multinodular infiltration of the spleen by an atypical mesenchymal neoplasia. Immunohistochemically there was an expression of histiocytic markers (CD4, CD68) as well as smooth muscle cell markers (SMA, H-Caldesmon) in the tumor cells. A diagnosis of an atypical spindle cell neoplasm showing features most suggestive of an IMT was rendered. Conclusion. Synchronous hepatic metastasis of an IMT of the spleen is a rarity. Therefore no experience in the treatment of these tumors exists. Fibroblastic reticular cell tumor is a differential diagnosis, but differentiation of these two entities is difficult.

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