scholarly journals Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses against Cryptosporidium Infection

2018 ◽  
Vol 201 (12) ◽  
pp. 3630-3640 ◽  
Author(s):  
Min Li ◽  
Ai-Yu Gong ◽  
Xin-Tian Zhang ◽  
Yang Wang ◽  
Nicholas W. Mathy ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Gene Transcription ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Cryptosporidium Infection ◽  
Defense Gene ◽  
Cell Responses ◽  
Rna Transcript

171 Intestinal Epithelial Cell-derived TSLP Regulates DC and CD4 T Cell Responses in the Gastrointestinal Tract

Cytokine ◽  
2007 ◽  
Vol 39 (1) ◽  
pp. 47
Author(s):  
Colby Zaph ◽  
Amy E. Troy ◽  
Betsy C. Taylor ◽  
Lisa D. Berman-Booty ◽  
Katherine J. Guild ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
T Cell Responses ◽  
Cd4 T Cell ◽  
Intestinal Epithelial ◽  
Cell Responses

scholarly journals A novel role for the Rho-associated kinase, ROCK, in IL-1-stimulated intestinal epithelial cell responses

2012 ◽  
Vol 280 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Brian J. Rafferty ◽  
Benjamin L. Unger ◽  
Aaron C. Perey ◽  
Steven P. Tammariello ◽  
Savvas Pavlides ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Cell Responses

scholarly journals Cryptosporidial Infection Suppresses Intestinal Epithelial Cell MAPK Signaling Impairing Host Anti-Parasitic Defense

2021 ◽  
Vol 9 (1) ◽  
pp. 151
Author(s):  
Wei He ◽  
Juan Li ◽  
Ai-Yu Gong ◽  
Silu Deng ◽  
Min Li ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial Cells ◽  
Mapk Signaling ◽  
Host Cells ◽  
Intestinal Epithelial ◽  
Cryptosporidium Infection ◽  
Cryptosporidial Infection

Cryptosporidium is a genus of protozoan parasites that infect the gastrointestinal epithelium of a variety of vertebrate hosts. Intestinal epithelial cells are the first line of defense and play a critical role in orchestrating host immunity against Cryptosporidium infection. To counteract host defense response, Cryptosporidium has developed strategies of immune evasion to promote parasitic replication and survival within epithelial cells, but the underlying mechanisms are largely unclear. Using various models of intestinal cryptosporidiosis, we found that Cryptosporidium infection caused suppression of mitogen-activated protein kinase (MAPK) signaling in infected murine intestinal epithelial cells. Whereas expression levels of most genes encoding the key components of the MAPK signaling pathway were not changed in infected intestinal epithelial cells, we detected a significant downregulation of p38/Mapk, MAP kinase-activated protein kinase 2 (Mk2), and Mk3 genes in infected host cells. Suppression of MAPK signaling was associated with an impaired intestinal epithelial defense against C. parvum infection. Our data suggest that cryptosporidial infection may suppress intestinal epithelial cell MAPK signaling associated with the evasion of host antimicrobial defense.

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