TLR9-Signaling Pathways Are Involved in Kilham Rat Virus-Induced Autoimmune Diabetes in the Biobreeding Diabetes-Resistant Rat

2007 ◽  
Vol 178 (2) ◽  
pp. 693-701 ◽  
Author(s):  
Danny Zipris ◽  
Egil Lien ◽  
Anjali Nair ◽  
Jenny X. Xie ◽  
Dale L. Greiner ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Autoimmune Diabetes ◽  
Tlr9 Signaling ◽  
Kilham Rat Virus

scholarly journals Immunoregulatory Role of Nitric Oxide in Kilham Rat Virus-Induced Autoimmune Diabetes in DR-BB Rats

2004 ◽  
Vol 173 (2) ◽  
pp. 1327-1335 ◽  
Author(s):  
Israel I. Mendez ◽  
Young-Hwa Chung ◽  
Hee-Sook Jun ◽  
Ji-Won Yoon
Keyword(s):  
Nitric Oxide ◽  
Autoimmune Diabetes ◽  
Bb Rats ◽  
Kilham Rat Virus

Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways

2013 ◽  
Vol 146 (1) ◽  
pp. 379-392 ◽  
Author(s):  
Jun Wang ◽  
Jingli Lu ◽  
Yan Lan ◽  
Hong Zhou ◽  
Weijie Li ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Autoimmune Diabetes ◽  
Tlr4 Signaling

scholarly journals Cellular and Molecular Mechanism for Kilham Rat Virus-Induced Autoimmune Diabetes in DR-BB Rats

2000 ◽  
Vol 165 (5) ◽  
pp. 2866-2876 ◽  
Author(s):  
Young-Hwa Chung ◽  
Hee Sook Jun ◽  
Mike Son ◽  
Min Bao ◽  
Hak Yeon Bae ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Autoimmune Diabetes ◽  
Bb Rats ◽  
Kilham Rat Virus

Kilham Rat Virus Triggers T-Cell-Dependent Autoimmune Diabetes in Multiple Strains of Rat

Diabetes ◽  
1996 ◽  
Vol 45 (5) ◽  
pp. 557-562 ◽  
Author(s):  
K. E. Ellerman ◽  
C. A. Richards ◽  
D. L. Guberski ◽  
W. R. Shek ◽  
A. A. Like
Keyword(s):  
T Cell ◽  
Autoimmune Diabetes ◽  
Multiple Strains ◽  
Kilham Rat Virus

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

2020 ◽  
Vol 134 (5) ◽  
pp. 473-512 ◽  
Author(s):  
Ryan P. Ceddia ◽  
Sheila Collins
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Signaling Pathways ◽  
G Protein ◽  
Uncoupling Protein ◽  
Beige Adipocytes ◽  
Nucleotide Regulation ◽  
Ucp1 Expression ◽  
Thermogenic Adipocytes ◽  
G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

Abstract #265 Clinical Characteristic of 31 Patients Diagnosed with Latent Autoimmune Diabetes in Adults (Lada) in a Multicentric Study in Mexico

2019 ◽  
Vol 25 ◽  
pp. 103
Author(s):  
Raquel Faradji ◽  
Carmen Castillo-Galindo ◽  
Natalia De la Garza-Hernandez ◽  
Sigfrido Miracle-Lopez ◽  
Claudia Ramirez-Renteria ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Multicentric Study ◽  
Latent Autoimmune Diabetes ◽  
Clinical Characteristic
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