scholarly journals Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection

2018 ◽  
Vol 200 (10) ◽  
pp. 3635-3646 ◽  
Author(s):  
Morgan Grau ◽  
Séverine Valsesia ◽  
Julien Mafille ◽  
Sophia Djebali ◽  
Martine Tomkowiak ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Lung Parenchyma ◽  
Memory Cd8 T Cells

scholarly journals Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection

2017 ◽  
Author(s):  
Morgan Grau ◽  
Séverine Valsesia ◽  
Julien Mafille ◽  
Sophia Djebali ◽  
Martine Tomkowiak ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Lung Parenchyma ◽  
Surface Expression ◽  
Comprehensive Analysis ◽  
Memory Cells ◽  
Memory Cd8 T Cells ◽  
Memory Phenotype

AbstractThe pool of memory-phenotype CD8 T cells is composed of antigen-induced (AI) and cytokine-induced innate (IN) cells. IN have been described as having similar properties to AI memory cells. However, we found that pathogen-induced AI memory cells can be distinguished from naturally-generated IN memory cells by surface expression of NKG2D. Using this marker, we described the increased functionalities of AI and IN memory CD8 T cells compared to naive cells, as shown by comprehensive analysis of cytokine secretion and gene expression. However, AI differed from IN memory CD8 T cells by their capacity to migrate to the lung parenchyma upon inflammation or infection, a process dependent on their expression of ITGA1/CD49a and ITGA4/CD49d integrins.

scholarly journals The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

Cell Reports ◽  
2020 ◽  
Vol 31 (13) ◽  
pp. 107827 ◽  
Author(s):  
Kristen E. Pauken ◽  
Jernej Godec ◽  
Pamela M. Odorizzi ◽  
Keturah E. Brown ◽  
Kathleen B. Yates ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Respiratory Viral Infection ◽  
Memory Cd8 T Cells ◽  
And Function

scholarly journals Programmed Death 1 Regulates Development of Central Memory CD8 T Cells after Acute Viral Infection

2011 ◽  
Vol 186 (11) ◽  
pp. 6280-6286 ◽  
Author(s):  
S. Rameeza Allie ◽  
Weijun Zhang ◽  
Shinchiro Fuse ◽  
Edward J. Usherwood
Keyword(s):  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Central Memory ◽  
Memory Cd8 T Cells ◽  
Acute Viral Infection ◽  
Programmed Death ◽  
Programmed Death 1

scholarly journals Antigen-independent memory CD8 T cells do not develop during chronic viral infection

2004 ◽  
Vol 101 (45) ◽  
pp. 16004-16009 ◽  
Author(s):  
E. J. Wherry ◽  
D. L. Barber ◽  
S. M. Kaech ◽  
J. N. Blattman ◽  
R. Ahmed
Keyword(s):  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Chronic Viral Infection ◽  
Memory Cd8 T Cells

scholarly journals CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

Immunity ◽  
2014 ◽  
Vol 41 (4) ◽  
pp. 633-645 ◽  
Author(s):  
Brian J. Laidlaw ◽  
Nianzhi Zhang ◽  
Heather D. Marshall ◽  
Mathew M. Staron ◽  
Tianxia Guan ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Cd4 T Cell ◽  
Memory Cd8 T Cells ◽  
Cd4 T Cell Help ◽  
Influenza Viral Infection ◽  
T Cell Help
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