scholarly journals Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model

2017 ◽  
Vol 199 (10) ◽  
pp. 3592-3603 ◽  
Author(s):  
Bing Catherine Wu ◽  
Amy Huei-Yi Lee ◽  
Robert E. W. Hancock
Keyword(s):  
Mouse Model ◽  
Sterile Inflammation ◽  
Inflammatory Activity ◽  
Innate Defense ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-Induced Low-Grade Chronic Inflammation

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2791 ◽  
Author(s):  
Hann ◽  
Zeng ◽  
Zong ◽  
Sakurai ◽  
Taniguchi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Expression ◽  
Tight Junction ◽  
Chronic Inflammation ◽  
Inflammatory Mediators ◽  
Macrophage Infiltration ◽  
Inflammatory Activity ◽  
Low Grade ◽  
Junction Protein ◽  
Anti Inflammatory

：The purpose of this study was to identify the anti-inflammatory activity and mechanism of isomaltodextrin (IMD) in a C57BL/6NCrl mouse model with lipopolysaccharide (LPS)-induced systemic low-grade chronic inflammation and the effect on inflammation-induced potential risk of metabolic disorders. Pre-treatment of IMD decreased the production of pro-inflammatory mediators, TNF-α and MCP-1, and stimulated the production of the anti-inflammatory mediator, adiponectin by increasing the protein expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) in the white adipose tissues. IMD administration reduced plasma concentrations of endotoxin, decreased macrophage infiltration into adipocytes, and increased expression of mucin 2, mucin 4, and the tight junction protein claudin 4. These results suggest that IMD administration exerted an anti-inflammatory effect on mice with LPS-induced inflammation, potentially by decreasing circulating endotoxin, suppressing pro-inflammatory mediators and macrophage infiltration, or by improving mucus or tight junction integrity. IMD exerted protein expression of insulin receptor subset-1 (IRS-1). IMD alleviated the disturbance of gut microflora in LPS-treated mice, as the number of B. bifidum, L. casei, and B. fragilis increased, and E. coli and C. difficile decreased, when compared to LPS-treated mice. The analysis of short chain fatty acids (SCFAs) further supported that the concentrations of acetic and butyric acids were positively correlated with IMD, as well as the number of beneficial bacteria. This study provides evidence that IMD possesses anti-inflammatory properties and exerts beneficial functions to prevent systemic low-grade chronic inflammation and reduces the risk of developing insulin resistance and associated metabolic diseases.

Anti-inflammatory Activity of Ursolic Acid in MPTP-Induced Parkinsonian Mouse Model

2019 ◽  
Vol 36 (3) ◽  
pp. 452-462 ◽  
Author(s):  
Sachchida Nand Rai ◽  
Walia Zahra ◽  
Saumitra Sen Singh ◽  
Hareram Birla ◽  
Chetan Keswani ◽  
...  
Keyword(s):  
Mouse Model ◽  
Ursolic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Anti‐inflammatory activity of arctigenin against PCV2 infection in a mouse model

2021 ◽  
Author(s):  
Lijun Wu ◽  
Jie Chen ◽  
Danna Zhou ◽  
Runshan Chen ◽  
Xiabing Chen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pcv2 Infection ◽  
Inflammatory Activity ◽  
Anti Inflammatory

The anti-inflammatory activity of telithromycin in a mouse model of septic shock

2007 ◽  
Vol 29 (3) ◽  
pp. 364-365 ◽  
Author(s):  
Magdalena Leiva ◽  
Alfonso Ruiz-Bravo ◽  
Encarnación Moreno ◽  
Maria Jimenez-Valera
Keyword(s):  
Septic Shock ◽  
Mouse Model ◽  
Inflammatory Activity ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document