scholarly journals Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection

2018 ◽  
Vol 200 (9) ◽  
pp. 3160-3169 ◽  
Author(s):  
Xavier Michelet ◽  
Amit Tuli ◽  
Huixian Gan ◽  
Carolina Geadas ◽  
Mahak Sharma ◽  
...  
Keyword(s):  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Plasma Membrane ◽  
Small Gtpase ◽  
Tuberculosis Infection ◽  
Membrane Repair ◽  
Mycobacterium Tuberculosis Infection ◽  
Plasma Membrane Repair

scholarly journals Plasma membrane repairs by small GTPase Rab3a

2016 ◽  
Vol 213 (6) ◽  
pp. 613-615 ◽  
Author(s):  
Camilla Raiborg ◽  
Harald Stenmark
Keyword(s):  
Plasma Membrane ◽  
Small Gtpase ◽  
Membrane Repair ◽  
Cell Biol ◽  
Plasma Membrane Repair

Lysosomes fuse with the plasma membrane to help repair membrane lesions, but how they are positioned close to these lesions is not fully understood. Now, Encarnação et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201511093) demonstrate that the lysosomal GTPase Rab3a and its effectors orchestrate lysosome positioning and plasma membrane repair.

scholarly journals Die another way: Ferroptosis drives tuberculosis pathology

2019 ◽  
Vol 216 (3) ◽  
pp. 471-473 ◽  
Author(s):  
Etienne Meunier ◽  
Olivier Neyrolles
Keyword(s):  
Cell Death ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Regulated Cell Death

In this issue of JEM, Amaral et al. (https://doi.org/10.1084/jem.20181776) provide the first evidence that ferroptosis, a newly described form of regulated cell death, is detrimental for the host during a Mycobacterium tuberculosis infection. This finding has important implications for the development of host-directed therapies for tuberculosis.

scholarly journals Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

2009 ◽  
Vol 10 (8) ◽  
pp. 899-906 ◽  
Author(s):  
Maziar Divangahi ◽  
Minjian Chen ◽  
Huixian Gan ◽  
Danielle Desjardins ◽  
Tyler T Hickman ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Plasma Membrane ◽  
Membrane Repair ◽  
Plasma Membrane Repair

scholarly journals Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Kai S. Beckwith ◽  
Marianne S. Beckwith ◽  
Sindre Ullmann ◽  
Ragnhild S. Sætra ◽  
Haelin Kim ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Plasma Membrane ◽  
Membrane Damage ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Plasma Membrane Damage

scholarly journals Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis

Physiology ◽  
2015 ◽  
Vol 30 (6) ◽  
pp. 438-448 ◽  
Author(s):  
Alisa D. Blazek ◽  
Brian J. Paleo ◽  
Noah Weisleder
Keyword(s):  
Cell Death ◽  
Plasma Membrane ◽  
Cell Membrane ◽  
Cellular Response ◽  
Cellular Functions ◽  
Membrane Repair ◽  
Central Process ◽  
Plasma Membrane Repair ◽  
Molecular Machinery ◽  
Membrane Resealing

Plasma membrane repair is a conserved cellular response mediating active resealing of membrane disruptions to maintain homeostasis and prevent cell death and progression of multiple diseases. Cell membrane repair repurposes mechanisms from various cellular functions, including vesicle trafficking, exocytosis, and endocytosis, to mend the broken membrane. Recent studies increased our understanding of membrane repair by establishing the molecular machinery contributing to membrane resealing. Here, we review some of the key proteins linked to cell membrane repair.

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