scholarly journals Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection

2017 ◽  
Vol 199 (5) ◽  
pp. 1567-1571 ◽  
Author(s):  
Tsukasa Nabekura ◽  
Dagmar Gotthardt ◽  
Kouta Niizuma ◽  
Tihana Trsan ◽  
Tina Jenus ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Cutting Edge ◽  
Mouse Cytomegalovirus ◽  
Cell Responses

scholarly journals Cutting Edge: IL-15-Independent NK Cell Response to Mouse Cytomegalovirus Infection

2009 ◽  
Vol 183 (5) ◽  
pp. 2911-2914 ◽  
Author(s):  
Joseph C. Sun ◽  
Averil Ma ◽  
Lewis L. Lanier
Keyword(s):  
Cell Response ◽  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Cutting Edge ◽  
Mouse Cytomegalovirus

scholarly journals Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection

2018 ◽  
Vol 200 (10) ◽  
pp. 3420-3428 ◽  
Author(s):  
Tsukasa Nabekura ◽  
Zhiying Chen ◽  
Casey Schroeder ◽  
Taeju Park ◽  
Eric Vivier ◽  
...  
Keyword(s):  
Cell Expansion ◽  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Adaptor Proteins ◽  
Mouse Cytomegalovirus

scholarly journals Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC

Blood ◽  
2011 ◽  
Vol 117 (26) ◽  
pp. 7032-7041 ◽  
Author(s):  
Isabel Barao ◽  
Maite Alvarez ◽  
Erik Ames ◽  
Mark T. Orr ◽  
Heather E. Stefanski ◽  
...  
Keyword(s):  
Nk Cells ◽  
Mhc Class I ◽  
Cytomegalovirus Infection ◽  
Immune Reconstitution ◽  
Nk Cell ◽  
Rapid Expansion ◽  
Normal Pattern ◽  
Mouse Cytomegalovirus ◽  
Single Positive ◽  
Independent Expansion

Abstract Natural killer (NK) cell subsets can be defined by the differential expression of inhibitory receptors for MHC class I molecules. Early after congenic HSCT, we found that Ly49G2high single-positive NK cells repopulated, displayed an activated phenotype, and were highly cytolytic. Over time, this subset was replaced with NK cells with a normal pattern of Ly49 expression. Treatment of mice with IL-2 also resulted in the rapid expansion of these Ly49G2high single-positive NK cells. Only the Ly49g (Klra7) Pro1 transcript was highly induced in both HSCT- and IL-2–treated recipients. MHC-independent expansion of the Ly49G2+ subset was also observed after Listeria monocytogenes or mouse cytomegalovirus infection. Our data indicate that during reconstitution after HSCT and various activation stimuli, Ly49G2+ NK cells represent the “first-responder” NK cells, which occur independently of NK-cell licensing via Ly49-MHC interactions. These data suggest that the inhibitory Ly49G2 receptor represents an activation marker on mouse NK cells under various conditions.

scholarly journals Ly49C Impairs NK Cell Memory in Mouse Cytomegalovirus Infection

2016 ◽  
Vol 197 (1) ◽  
pp. 128-140 ◽  
Author(s):  
Catherine A. Forbes ◽  
Anthony A. Scalzo ◽  
Mariapia A. Degli-Esposti ◽  
Jerome D. Coudert
Keyword(s):  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Mouse Cytomegalovirus ◽  
Cell Memory

scholarly journals Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection

2016 ◽  
Vol 7 ◽  
Author(s):  
Maja Arapović ◽  
Ilija Brizić ◽  
Branka Popović ◽  
Slaven Jurković ◽  
Stefan Jordan ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Mouse Cytomegalovirus ◽  
Cell Homeostasis

scholarly journals Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197596 ◽  
Author(s):  
Silvia Gimeno Brias ◽  
Morgan Marsden ◽  
Jessica Forbester ◽  
Mathew Clement ◽  
Cordelia Brandt ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Murine Cytomegalovirus ◽  
Cell Responses ◽  
Interferon Lambda

scholarly journals The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection

2016 ◽  
Vol 12 (9) ◽  
pp. e1005895 ◽  
Author(s):  
Eleni Panagioti ◽  
Anke Redeker ◽  
Suzanne van Duikeren ◽  
Kees LMC Franken ◽  
Jan Wouter Drijfhout ◽  
...  
Keyword(s):  
T Cell ◽  
Cytomegalovirus Infection ◽  
Peptide Vaccine ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Mouse Cytomegalovirus ◽  
Cell Responses
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