scholarly journals Response to Comment on “Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells”

2017 ◽  
Vol 198 (11) ◽  
pp. 4188.2-4188
Author(s):  
Gera Goverse ◽  
Martje Erkelens ◽  
Reina Mebius
Keyword(s):  
Fatty Acids ◽  
Dendritic Cells ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Intestinal Epithelial ◽  
Tolerogenic Dendritic Cells ◽  
Chain Fatty Acids

Short-chain fatty acids regulate IGF-binding protein secretion by intestinal epithelial cells

1998 ◽  
Vol 275 (1) ◽  
pp. E55-E63 ◽  
Author(s):  
Akiyoshi Nishimura ◽  
Mika Fujimoto ◽  
Satoshi Oguchi ◽  
Robert D. Fusunyan ◽  
Richard P. MacDermott ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Intestinal Epithelial ◽  
Igf Binding ◽  
Igfbp 3 ◽  
Chain Fatty Acids

Gastrointestinal epithelial cells secrete insulin-like growth factor (IGF)-binding proteins (IGFBPs), which modulate the actions of IGFs on cell proliferation and differentiation. Short-chain fatty acids are bacterial metabolites from unabsorbed carbohydrate (including fiber). We hypothesized that they may alter the pattern of IGFBPs secreted by epithelial cells as part of a wider phenomenon by which luminal molecules regulate gastrointestinal epithelial cell signaling. The intestinal epithelial cell line, Caco-2, predominantly secretes IGFBP-3; however, butyrate increased the secretion of IGFBP-2 in a dose-dependent and reversible manner. Butyrate decreased the secretion of IGFBP-3. Butyrate altered only the synthesis and not the cell sorting of IGFBPs because 1) the secretion of IGFBPs remained polarized despite changes in their rates of production, and 2) IGFBP secretion corresponded to mRNA accumulation. The ability of short-chain fatty acids or the fungicide trichostatin A to stimulate IGFBP-2 correlated with their actions on histone acetylation. In conclusion, intestinal epithelial cells respond to short-chain fatty acids by altering secretion of IGFBPs.

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