scholarly journals IL-12 Administration Reveals Diabetogenic T Cells in Genetically Resistant I-Eα-Transgenic Nonobese Diabetic Mice: Resistance to Autoimmune Diabetes Is Associated with Binding of Eα-Derived Peptides to the I-Ag7 Molecule

2001 ◽  
Vol 167 (7) ◽  
pp. 4104-4114 ◽  
Author(s):  
Sylvie Trembleau ◽  
Silvia Gregori ◽  
Giuseppe Penna ◽  
Irmina Gorny ◽  
Luciano Adorini
Keyword(s):  
T Cells ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice

Diabetes ◽  
1998 ◽  
Vol 47 (6) ◽  
pp. 894-899 ◽  
Author(s):  
R. Tisch ◽  
R. S. Liblau ◽  
X. D. Yang ◽  
P. Liblau ◽  
H. O. McDevitt
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice

2013 ◽  
Vol 191 (2) ◽  
pp. 594-607 ◽  
Author(s):  
Li-Tzu Yeh ◽  
Shi-Chuen Miaw ◽  
Ming-Hong Lin ◽  
Feng-Cheng Chou ◽  
Shing-Jia Shieh ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Cutting Edge: Vasostatin-1–Derived Peptide ChgA29–42 Is an Antigenic Epitope of Diabetogenic BDC2.5 T Cells in Nonobese Diabetic Mice

2011 ◽  
Vol 186 (7) ◽  
pp. 3831-3835 ◽  
Author(s):  
Enayat Nikoopour ◽  
Christian Sandrock ◽  
Katrina Huszarik ◽  
Olga Krougly ◽  
Edwin Lee-Chan ◽  
...  
Keyword(s):  
T Cells ◽  
Cutting Edge ◽  
Antigenic Epitope ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

Long-Term Metabolic Control of Autoimmune Diabetes in Spontaneously Diabetic Nonobese Diabetic Mice by Nonvascularized Microencapsulated Adult Porcine Islets

2009 ◽  
Vol 88 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Hong Cui ◽  
Carol Tucker-Burden ◽  
Sean M. D. Cauffiel ◽  
Adrienne K. Barry ◽  
Neal N. Iwakoshi ◽  
...  
Keyword(s):  
Metabolic Control ◽  
Autoimmune Diabetes ◽  
Diabetic Mice ◽  
Porcine Islets ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

1997 ◽  
Vol 186 (7) ◽  
pp. 989-997 ◽  
Author(s):  
David Kägi ◽  
Bernhard Odermatt ◽  
Peter Seiler ◽  
Rolf M. Zinkernagel ◽  
Tak W. Mak ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Diabetes ◽  
Cytotoxic T Cells ◽  
Disease Onset ◽  
Spontaneous Diabetes ◽  
Cell Loss ◽  
Β Cell ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice ◽  
Deficient Mice

To investigate the role of T cell–mediated, perforin-dependent cytotoxicity in autoimmune diabetes, perforin-deficient mice were backcrossed with the nonobese diabetes mouse strain. It was found that the incidence of spontaneous diabetes over a 1 yr period was reduced from 77% in perforin +/+ control to 16% in perforin-deficient mice. Also, the disease onset was markedly delayed (median onset of 39.5 versus 19 wk) in the latter. Insulitis with infiltration of CD4+ and CD8+ T cells occurred similarly in both groups of animals. Lower incidence and delayed disease onset were also evident in perforin-deficient mice when diabetes was induced by cyclophosphamide injection. Thus, perforin-dependent cytotoxicity is a crucial effector mechanism for β cell elimination by cytotoxic T cells in autoimmune diabetes. However, in the absence of perforin chronic inflammation of the islets can lead to diabetogenic β cell loss by less efficient secondary effector mechanisms.

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