scholarly journals Human Mast Cells Release Metalloproteinase-9 on Contact with Activated T Cells: Juxtacrine Regulation by TNF-α

2001 ◽  
Vol 167 (7) ◽  
pp. 4008-4016 ◽  
Author(s):  
Dana Baram ◽  
Gayle G. Vaday ◽  
Pazit Salamon ◽  
Ilana Drucker ◽  
Rami Hershkoviz ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Activated T Cells ◽  
Human Mast Cells ◽  
Tnf Α ◽  
Metalloproteinase 9

Human Mast Cells Release Oncostatin M (OSM) Specifically on Contact with Activated T Cells

2006 ◽  
Vol 117 (2) ◽  
pp. S67
Author(s):  
P. Salamon ◽  
N. Shoham ◽  
I. Puxeddu ◽  
F. Levi-Schaffer ◽  
Y.A. Mekori
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Oncostatin M ◽  
Activated T Cells ◽  
Human Mast Cells

Human mast cells release Interleukin-8 and induce neutrophil chemotaxis on contact with activated T cells

Allergy ◽  
2005 ◽  
Vol 60 (10) ◽  
pp. 1316-1319 ◽  
Author(s):  
P. Salamon ◽  
N. G. Shoham ◽  
R. Gavrieli ◽  
B. Wolach ◽  
Y. A. Mekori
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Interleukin 8 ◽  
Neutrophil Chemotaxis ◽  
Activated T Cells ◽  
Human Mast Cells

Human Mast Cells are Activated by Microparticles Released from Activated T cells

2010 ◽  
Vol 125 (2) ◽  
pp. AB180
Author(s):  
I. Shefler ◽  
P. Salamon ◽  
A. Mor ◽  
Y.A. Mekori
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Activated T Cells ◽  
Human Mast Cells

Human mast cells release oncostatin M on contact with activated T cells: Possible biologic relevance

2008 ◽  
Vol 121 (2) ◽  
pp. 448-455.e5 ◽  
Author(s):  
Pazit Salamon ◽  
Nitza G. Shoham ◽  
Ilaria Puxeddu ◽  
Yosef Paitan ◽  
Francesca Levi-Schaffer ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Oncostatin M ◽  
Activated T Cells ◽  
Human Mast Cells

Human Mast Cells Stimulate Activated T Cells

2008 ◽  
Vol 1144 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Theoharis C. Theoharides ◽  
Duraisamy Kempuraj ◽  
Taxiarchis Kourelis ◽  
Akrivi Manola
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Activated T Cells ◽  
Human Mast Cells

scholarly journals Granzyme D Is a Novel Murine Mast Cell Protease That Is Highly Induced by Multiple Pathways of Mast Cell Activation

2013 ◽  
Vol 81 (6) ◽  
pp. 2085-2094 ◽  
Author(s):  
Elin Rönnberg ◽  
Gabriela Calounova ◽  
Bengt Guss ◽  
Anders Lundequist ◽  
Gunnar Pejler
Keyword(s):  
T Cells ◽  
Mast Cell ◽  
Mast Cells ◽  
Serine Proteases ◽  
Cell Activation ◽  
Calcium Ionophore ◽  
Mast Cell Activation ◽  
Activated T Cells ◽  
Mast Cell Protease ◽  
Murine Mast Cell

ABSTRACTGranzymes are serine proteases known mostly for their role in the induction of apoptosis. Granzymes A and B have been extensively studied, but relatively little is known about granzymes C to G and K to M. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, but the function of granzyme D is unknown. Here we show that granzyme D is expressed by murine mast cells and that its level of expression correlates positively with the extent of mast cell maturation. Coculture of mast cells with live, Gram-positive bacteria caused a profound, Toll-like receptor 2 (TLR2)-dependent induction of granzyme D expression. Granzyme D expression was also induced by isolated bacterial cell wall components, including lipopolysaccharide (LPS) and peptidoglycan, and by stem cell factor, IgE receptor cross-linking, and calcium ionophore stimulation. Granzyme D was released into the medium in response to mast cell activation. Granzyme D induction was dependent on protein kinase C and nuclear factor of activated T cells (NFAT). Together, these findings identify granzyme D as a novel murine mast cell protease and implicate granzyme D in settings where mast cells are activated, such as bacterial infection and allergy.

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