scholarly journals Human Uveal Melanoma Cells Produce Macrophage Migration-Inhibitory Factor to Prevent Lysis by NK Cells

2000 ◽  
Vol 165 (2) ◽  
pp. 710-715 ◽  
Author(s):  
Amanda C. Repp ◽  
Elizabeth S. Mayhew ◽  
Sherine Apte ◽  
Jerry Y. Niederkorn
Keyword(s):  
Nk Cells ◽  
Uveal Melanoma ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Melanoma Cells ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Human decidual natural killer cells as a source and target of macrophage migration inhibitory factor

Reproduction ◽  
2006 ◽  
Vol 131 (1) ◽  
pp. 175-182 ◽  
Author(s):  
F Arcuri ◽  
M Cintorino ◽  
A Carducci ◽  
S Papa ◽  
M G Riparbelli ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
K562 Cells ◽  
Cytolytic Activity ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Dependent Manner ◽  
Unk Cells

The human uterine mucosa of early pregnancy is largely populated by CD56brightnatural killer (NK) cells (uterine (u) NK cells). The specific functions of these cells are still unknown, but their interaction and response to foetal trophoblasts are thought to be important for the establishment of a successful pregnancy. The study reported herein shows that uNK cells respond to, and produce, macrophage migration inhibitory factor (MIF), a cytokine highly expressed in the human placenta and in the cyclic and pregnant endometrium. Recombinant human MIF reduced in a dose-dependent manner the cytolytic activity of purified uNK cells against K562 cells. RT-PCR, Western blot analysis and ELISA demonstrated the synthesis and secretion of the cytokine by uNK cells. Double immunofluorescence staining showed the presence of MIF in uterine CD56 + cells. Finally, neutralization of the endogenous cytokine by a polyclonal antibody resulted in a sharp increase in the cytolytic activity of uNK cells. These findings indicate the existence of a previously unrevealed paracrine and autocrine action of MIF on uNK cells and support its contribution to the immune privilege at the maternal–foetal interface.

scholarly journals Role of Macrophage Migration Inhibitory Factor (MIF) in Melanoma

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 529 ◽  
Author(s):  
Laura Soumoy ◽  
Nadège Kindt ◽  
Ghanem Ghanem ◽  
Sven Saussez ◽  
Fabrice Journe
Keyword(s):  
Metastatic Melanoma ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Melanoma Cells ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Mutational Status ◽  
Cancer Types ◽  
Reported Data

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine involved in the carcinogenesis of many cancer types. Here, we review the published experimental and clinical data for MIF and its involvement in melanoma. All reported data show that MIF is overexpressed in melanoma cells, especially in case of metastatic disease. Clinical studies also indicate that high MIF expression is positively associated with aggressiveness of the disease. Some data also highlight the implication of MIF in angiogenesis, immunity and metastasis in melanoma cell lines, as well as the availability of different therapeutic options targeting MIF for the treatment of metastatic melanoma. Indeed, the main problem in metastatic melanoma is the lack of long-term effective treatment. This is linked to the capacity of melanoma cells to mutate very quickly and/or activate alternative signaling pathways. Thus, MIF targeting therapies could provide a new effective way of treating melanoma. Moreover, cell sensitivity to MIF depletion does not correlate with the BRAF mutational status. Regarding the fact that many melanoma patients carry a BRAF mutation, and that they develop resistance to BRAF inhibitors, this observation is very interesting as MIF inhibitors could be used to treat many patients in relapse after treatment with an inhibitor of the mutant BRAF protein.

287: Macrophage Migration Inhibitory Factor and its Receptor CD74 are Upregulated in the Urothelium of Interstitial Cystitis Patients

2006 ◽  
Vol 175 (4S) ◽  
pp. 95-96 ◽  
Author(s):  
Pedro L. Vera ◽  
Kenneth A. lczkowski ◽  
Robert M. Moldwin ◽  
Leslie Kushner ◽  
Katherine L. Meyer-Siegler
Keyword(s):  
Interstitial Cystitis ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration
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