scholarly journals Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation

2017 ◽  
Vol 198 (11) ◽  
pp. 4244-4254 ◽  
Author(s):  
Sara A. Gibson ◽  
Wei Yang ◽  
Zhaoqi Yan ◽  
Yudong Liu ◽  
Amber L. Rowse ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Protein Kinase ◽  
Regulatory T Cell ◽  
Th17 Cell ◽  
Protein Kinase Ck2 ◽  
T Cell Differentiation ◽  
Kinase Ck2

scholarly journals Requirement for CD28 in Effector Regulatory T Cell Differentiation, CCR6 Induction, and Skin Homing

2015 ◽  
Vol 195 (9) ◽  
pp. 4154-4161 ◽  
Author(s):  
Ruan Zhang ◽  
Christopher M. Borges ◽  
Martin Y. Fan ◽  
John E. Harris ◽  
Laurence A. Turka
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Differentiation ◽  
Skin Homing

scholarly journals HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling

2020 ◽  
Vol 117 (24) ◽  
pp. 13740-13749 ◽  
Author(s):  
Yusuke Higuchi ◽  
Jun-ichirou Yasunaga ◽  
Yu Mitagami ◽  
Hirotake Tsukamoto ◽  
Kazutaka Nakashima ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Transgenic Mice ◽  
Regulatory T Cell ◽  
T Cell Differentiation ◽  
Cytokine Signaling ◽  
Viral Gene ◽  
Cell Leukemia Virus Type ◽  
Human T Cell

Human T cell leukemia virus type 1 (HTLV-1) is the etiologic agent of a T cell neoplasm and several inflammatory diseases. A viral gene, HTLV-1 bZIP factor (HBZ), induces pathogenic Foxp3-expressing T cells and triggers systemic inflammation and T cell lymphoma in transgenic mice, indicating its significance in HTLV-1–associated diseases. Here we show that, unexpectedly, a proinflammatory cytokine, IL-6, counteracts HBZ-mediated pathogenesis. Loss of IL-6 accelerates inflammation and lymphomagenesis in HBZ transgenic mice. IL-6 innately inhibits regulatory T cell differentiation, suggesting that IL-6 functions as a suppressor against HBZ-associated complications. HBZ up-regulates expression of the immunosuppressive cytokine IL-10. IL-10 promotes T cell proliferation only in the presence of HBZ. As a mechanism of growth promotion by IL-10, HBZ interacts with STAT1 and STAT3 and modulates the IL-10/JAK/STAT signaling pathway. These findings suggest that HTLV-1 promotes the proliferation of infected T cells by hijacking the machinery of regulatory T cell differentiation. IL-10 induced by HBZ likely suppresses the host immune response and concurrently promotes the proliferation of HTLV-1 infected T cells.

Sign in / Sign up

Export Citation Format

Share Document