scholarly journals NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells

2017 ◽  
Vol 198 (8) ◽  
pp. 3336-3344 ◽  
Author(s):  
Jiacheng Bi ◽  
Lulu Cui ◽  
Guang Yu ◽  
Xiaolu Yang ◽  
Youhai Chen ◽  
...  
Keyword(s):  
Nk Cells ◽  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 2

scholarly journals Innate Lymphoid Cells in Human Pregnancy

2020 ◽  
Vol 11 ◽  
Author(s):  
João Mendes ◽  
Ana Luísa Areia ◽  
Paulo Rodrigues-Santos ◽  
Manuel Santos-Rosa ◽  
Anabela Mota-Pinto
Keyword(s):  
Nk Cells ◽  
Innate Lymphoid Cells ◽  
Adverse Outcomes ◽  
Lymphoid Cells ◽  
Perinatal Medicine ◽  
Effector Cells ◽  
Human Pregnancy ◽  
Group 3 ◽  
Group 2 ◽  
In Pregnancy

Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ILCs, group 2 ILCs, group 3 ILCs, and lymphoid tissue inducers (LTi). Functionally, these cells resemble the T helper population but lack the expression of recombinant genes, which is essential for the formation of T cell receptors. In this work, the authors address the distinction between peripheral and decidual NK cells, highlighting their diversity in ILC biology and its relevance to human pregnancy. ILCs are effector cells that are important in promoting immunity, inflammation, and tissue repair. Recent studies have directed their attention to ILC actions in pregnancy. Dysregulation or expansion of pro-inflammatory ILC populations as well as abnormal tolerogenic responses may directly interfere with pregnancy, ultimately resulting in pregnancy loss or adverse outcomes. In this review, we characterize these cells, considering recent findings and addressing knowledge gaps in perinatal medicine in the context of ILC biology. Moreover, we discuss the relevance of these cells not only to the process of immune tolerance, but also in disease.

scholarly journals Androgen signaling negatively controls group 2 innate lymphoid cells

2017 ◽  
Vol 214 (6) ◽  
pp. 1581-1592 ◽  
Author(s):  
Sophie Laffont ◽  
Eve Blanquart ◽  
Magali Savignac ◽  
Claire Cénac ◽  
Gilles Laverny ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Lung Inflammation ◽  
Inflammatory Responses ◽  
Allergic Airway Inflammation ◽  
Innate Lymphoid Cells ◽  
Protective Role ◽  
Lymphoid Cells ◽  
Peripheral Tissues ◽  
Group 2

Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33–driven lung inflammation, correlating with an impaired expansion of lung ILC2s. Importantly, orchiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33–mediated lung inflammation. ILC2Ps express the androgen receptor (AR), and AR signaling inhibits their differentiation into mature ILC2s. Finally, we show that hematopoietic AR expression limits IL-33–driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. Thus, androgens play a crucial protective role in type 2 airway inflammation by negatively regulating ILC2 homeostasis, thereby limiting their capacity to expand locally in response to IL-33.

scholarly journals Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

Immunity ◽  
2014 ◽  
Vol 40 (3) ◽  
pp. 425-435 ◽  
Author(s):  
Timotheus Y.F. Halim ◽  
Catherine A. Steer ◽  
Laura Mathä ◽  
Matthew J. Gold ◽  
Itziar Martinez-Gonzalez ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
T Helper ◽  
T Helper 2 ◽  
Allergic Lung Inflammation ◽  
Group 2

scholarly journals IL-17–producing ST2+ group 2 innate lymphoid cells play a pathogenic role in lung inflammation

2019 ◽  
Vol 143 (1) ◽  
pp. 229-244.e9 ◽  
Author(s):  
Ting Cai ◽  
Jinxin Qiu ◽  
Yan Ji ◽  
Wenjing Li ◽  
Zhaoyun Ding ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Pathogenic Role ◽  
Group 2

scholarly journals Group 2 innate lymphoid cells in lung inflammation

Immunology ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Bobby W.S. Li ◽  
Rudi W. Hendriks
Keyword(s):  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 2

scholarly journals DCIR Modulates Cockroach Allergen-Induced Lung Inflammation through Group 2 innate Lymphoid Cells

2020 ◽  
Vol 145 (2) ◽  
pp. AB14
Author(s):  
Xinyue Hu ◽  
Jingsi Chen ◽  
Chengping Hu ◽  
Danh Do ◽  
Juntao Feng ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Cockroach Allergen ◽  
Group 2

Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation

2018 ◽  
Vol 323 ◽  
pp. 33-40 ◽  
Author(s):  
Fujimi Kudo ◽  
Masashi Ikutani ◽  
Masanori Iseki ◽  
Satoshi Takaki
Keyword(s):  
Cyclosporin A ◽  
Lung Inflammation ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 2
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