scholarly journals Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma

2017 ◽  
Vol 198 (5) ◽  
pp. 1805-1814 ◽  
Author(s):  
Hesam Movassagh ◽  
Lianyu Shan ◽  
Ashfaque Mohammed ◽  
Andrew J. Halayko ◽  
Abdelilah S. Gounni
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma

Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma

2006 ◽  
Vol 1760 (7) ◽  
pp. 1088-1095 ◽  
Author(s):  
Mohamed El Gazzar ◽  
Rabab El Mezayen ◽  
Mark R. Nicolls ◽  
John C. Marecki ◽  
Stephen C. Dreskin
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma

Herbal decoction Divya-Swasari-Kwath attenuates airway inflammation and remodeling through Nrf-2 mediated antioxidant lung defence in mouse model of allergic asthma

Phytomedicine ◽  
2020 ◽  
Vol 78 ◽  
pp. 153295 ◽  
Author(s):  
Acharya Balkrishna ◽  
Siva Kumar Solleti ◽  
Hoshiyar Singh ◽  
Sudeep Verma ◽  
Niti Sharma ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Herbal Decoction

Azithromycin Attenuates Airway Inflammation in a Noninfectious Mouse Model of Allergic Asthma

CHEST Journal ◽  
2009 ◽  
Vol 136 (2) ◽  
pp. 498-506 ◽  
Author(s):  
Avraham Beigelman ◽  
Sean Gunsten ◽  
Cassandra L. Mikols ◽  
Ilan Vidavsky ◽  
Carolyn L. Cannon ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma

scholarly journals Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0167098 ◽  
Author(s):  
Jin Choi ◽  
Bo Kyong Choi ◽  
Jin seok Kim ◽  
Jae-Won Lee ◽  
Hyun Ah Park ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Picroside Ii

scholarly journals Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma

2011 ◽  
Vol 108 (1) ◽  
pp. 130-139 ◽  
Author(s):  
Ren-Long Jan ◽  
Kung-Chih Yeh ◽  
Miao-Hsi Hsieh ◽  
Yen-Lin Lin ◽  
Hui-Fang Kao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Oral Administration ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Transforming Growth Factor ◽  
Allergen Challenge ◽  
Inflammatory Cells ◽  
Airway Responsiveness ◽  
High Dose ◽  
Lactobacillus Gasseri

Probiotics are normal inhabitants of the gastrointestinal tract of man and are widely considered to exert a number of beneficial effects in many diseases. But the mechanism by which they modulate the immune system is poorly understood. The present study was planned to explore the anti-allergic effect of Lactobacillus gasseri on a mouse model of allergic asthma. Dermatophoides pteronyssinus (Der p) sensitised and challenged BALB/c mice were orally administered via oral administration with three different doses of L. gasseri (low, 1 × 106 colony-forming units (CFU); medium, 2 × 106 CFU; high, 4 × 106 CFU), in 700 μl of PBS daily, starting from 2 weeks before Der p sensitisation for 4 weeks. After the allergen challenge, airway responsiveness to methacholine, influx of inflammatory cells to the lung, and cytokine levels in bronchoalveolar lavage (BAL) fluids and splenocytes culture were assessed. Our results showed that oral administration of a high dose of L. gasseri (4 × 106 CFU) decreased airway responsiveness to methacholine, attenuated the influx of inflammatory cells to the airways and reduced the levels of TNF-α, thymus and activation-regulated chemokine (TARC) and IL-17A in BAL fluids of Der p-sensitised and -challenged mice. Moreover, L. gasseri decreased IL-17A production in transforming growth factor-α and IL-6 stimulated splenocytes and cell numbers of IL-17 producing alveolar macrophages in L. gasseri-treated mice as compared to non-treated, Der p-sensitised and -challenged mice. In conclusion, oral administration with L. gasseri can attenuate major characteristics of allergen-induced airway inflammation and IL-17 pro-inflammatory immune response in a mouse model of allergic asthma, which may have clinical implication in the preventive or therapeutic potential in allergic asthma.

Trigonella foenum-graecum alleviates airway inflammation of allergic asthma in ovalbumin-induced mouse model

2017 ◽  
Vol 482 (4) ◽  
pp. 1284-1288 ◽  
Author(s):  
Chun Hua Piao ◽  
Thi Tho Bui ◽  
Chang Ho Song ◽  
Hee Soon Shin ◽  
Dong-Hwa Shon ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Trigonella Foenum Graecum

Platycodin D Attenuates Airway Inflammation in a Mouse Model of Allergic Asthma by Regulation NF-κB Pathway

Inflammation ◽  
2015 ◽  
Vol 38 (3) ◽  
pp. 1221-1228 ◽  
Author(s):  
Tianzhu Zhang ◽  
Shihai Yang ◽  
Juan Du ◽  
Yao Jinfu ◽  
Wang Shumin
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Platycodin D
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