scholarly journals Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

2016 ◽  
Vol 198 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Dolores Redondo-Pachón ◽  
Marta Crespo ◽  
Jose Yélamos ◽  
Aura Muntasell ◽  
María José Pérez-Sáez ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Cell Response ◽  
Cytomegalovirus Infection ◽  
Nk Cell ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Risk Factors for Late-Onset Cytomegalovirus Infection or Disease in Kidney Transplant Recipients

2014 ◽  
Vol 97 (5) ◽  
pp. 569-575 ◽  
Author(s):  
Alainna J. Jamal ◽  
Shahid Husain ◽  
Yanhong Li ◽  
Olusegun Famure ◽  
S. Joseph Kim
Keyword(s):  
Risk Factors ◽  
Kidney Transplant ◽  
Cytomegalovirus Infection ◽  
Late Onset ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

scholarly journals CD56+CD57+ infiltrates as the most predominant subset of intragraft natural killer cells in renal transplant biopsies with antibody-mediated rejection

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hey Rim Jung ◽  
Mi Joung Kim ◽  
Yu-Mee Wee ◽  
Jee Yeon Kim ◽  
Monica Young Choi ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Nk Cells ◽  
Natural Killer ◽  
Kidney Transplant ◽  
Graft Failure ◽  
Nk Cell ◽  
Cell Infiltration ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Antibody Mediated Rejection

Abstract Little is known about the characteristics and clinical implications of specific subsets of intragraft natural killer (NK) cells in kidney transplant recipients. We analyzed 39 for-cause renal transplant biopsies performed at our center from May 2015 to July 2017. According to histopathologic reports, 8 patients (20.5%) had no rejection (NR), 11 (28.2%) had T cell-mediated rejections (TCMR) only, and 20 (51.3%) had antibody-mediated rejection (ABMR). NK cells were defined as CD3–CD56+ lymphocytes that are positive for CD57, CD49b, NKG2A, or KIR. The density of NK cells was significantly higher in the ABMR group (2.57 ± 2.58/mm2) than in the NR (0.12 ± 0.22/mm2) or the TCMR (0.25 ± 0.34/mm2) group (P = 0.002). Notably, CD56+CD57+ infiltrates (2.16 ± 1.89) were the most frequently observed compared with CD56+CD49b+ (0.05 ± 0.13), CD56+NKG2A+ (0.21 ± 0.69), and CD56+KIR+ (0.15 ± 0.42) cells in the ABMR group (P < 0.001). Death-censored graft failure was significantly higher in patients with NK cell infiltration than those without (Log-rank test, P = 0.025). In conclusion, CD56+CD57+ infiltrates are a major subset of NK cells in kidney transplant recipients with ABMR and NK cell infiltration is significantly associated with graft failure post-transplant.

Risk of opportunistic infection in kidney transplant recipients with cytomegalovirus infection and associated outcomes

2019 ◽  
Vol 21 (3) ◽  
pp. e13080 ◽  
Author(s):  
Margaret R. Jorgenson ◽  
Jillian L. Descourouez ◽  
Brianna Cardinale ◽  
Beini Lyu ◽  
Brad C. Astor ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Opportunistic Infection ◽  
Cytomegalovirus Infection ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients
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