scholarly journals Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia

2017 ◽  
Vol 198 (4) ◽  
pp. 1740-1747 ◽  
Author(s):  
Qingsong Yin ◽  
Mariela Sivina ◽  
Harlan Robins ◽  
Erik Yusko ◽  
Marissa Vignali ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

scholarly journals Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

2015 ◽  
Vol 22 (1) ◽  
pp. 167-174 ◽  
Author(s):  
Anna Vardi ◽  
Andreas Agathangelidis ◽  
Evangelia Stalika ◽  
Maria Karypidou ◽  
Alexandra Siorenta ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Antigen Selection

The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire

Blood ◽  
2010 ◽  
Vol 116 (16) ◽  
pp. 2968-2974 ◽  
Author(s):  
Batoul Pourgheysari ◽  
Rachel Bruton ◽  
Helen Parry ◽  
Lucinda Billingham ◽  
Chris Fegan ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Cell Chronic Lymphocytic Leukemia

Abstract B-cell chronic lymphocytic leukemia is associated with immune suppression and an altered T-cell repertoire with expansion of memory cells. Cytomegalovirus (CMV) is a common herpes virus that elicits a strong virus-specific T-cell immune response after infection. We studied the CMV-specific CD4+ T-cell response in 45 patients and 35 control subjects and demonstrated that it was markedly expanded in the patient group, averaging 11% of the CD4+ pool compared with 4.7% in controls. The magnitude of the CMV-specific CD4+ immune response increased with disease stage and was particularly high in patients who received chemotherapy. Within this group, the CMV-specific response comprised over 46% of the CD4+ T-cell repertoire in some patients. Serial analysis revealed that CMV-specific immunity increased during treatment with chemotherapy and remained stable thereafter. CMV-seropositive patients exhibited a markedly altered CD4+ T-cell repertoire with increased numbers of CD45R0+ T cells and a reduction in CD27, CD28, and CCR7 expression. Overall survival was reduced by nearly 4 years in CMV-seropositive patients, although this did not reach statistical significance. CLL patients therefore demonstrate an expansion of the CD4+ CMV-specific immune response, which is likely to contribute to the immunological and clinical features of this disease.

scholarly journals Characterization of human cytomegalovirus peptide–specific CD8+ T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells

Blood ◽  
2002 ◽  
Vol 99 (1) ◽  
pp. 213-223 ◽  
Author(s):  
Karl Peggs ◽  
Stephanie Verfuerth ◽  
Arnold Pizzey ◽  
Jenni Ainsworth ◽  
Paul Moss ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Viral Replication ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity ◽  
Clonal Composition

Under conditions of impaired T-cell immunity, human cytomegalovirus (HCMV) can reactivate from lifelong latency, resulting in potentially fatal disease. A crucial role for CD8+ T cells has been demonstrated in control of viral replication, and high levels of HCMV-specific cytotoxic T-lymphocytes are seen in immunocompetent HCMV-seropositive individuals despite very low viral loads. Elucidation of the minimum portion of the anti-HCMV T-cell repertoire that is required to suppress viral replication requires further study of clonal composition. The ability of dendritic cells to take up and process exogenous viral antigen by constitutive macropinocytosis was used to study HCMV-specific T-cell memory in the absence of viral replication. The specificity and clonal composition of the CD8+ T-cell responses were evaluated using HLA tetrameric complexes and T-cell receptor β chain (TCRBV) spectratypic analyses. There was a skewed reactivity toward the matrix protein pp65, with up to 40-fold expansion of CD8+ T cells directed toward a single peptide-MHC combination. Individual expansions detected on TCRBV spectratype analysis were HCMV-specific and composed of single or highly restricted numbers of clones. There was preferential TCRBV gene usage (BV6.1/6.2, BV8, and BV13 in HLA-A*0201+ individuals) but lack of conservation of CDR3 length and junctional motifs between donors. While there was a spectrum of TCR repertoire diversity directed toward individual MHC-peptide combinations between donors, a relatively small number of clones appeared to predominate the response in each case. These data provide further insight into the range of anti-HCMV responses and will aid the design and monitoring of adoptive immunotherapy protocols.

scholarly journals Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

2018 ◽  
Vol 202 (2) ◽  
pp. 476-483 ◽  
Author(s):  
Paul Lindau ◽  
Rithun Mukherjee ◽  
Miriam V. Gutschow ◽  
Marissa Vignali ◽  
Edus H. Warren ◽  
...  
Keyword(s):  
T Cell ◽  
The Elderly ◽  
Cd8 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

scholarly journals Altered T-cell repertoire diversity in septic shock patients

Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P223
Author(s):  
N Takeyama ◽  
A Tomino ◽  
M Hashiba ◽  
A Hirakawa ◽  
T Hattori ◽  
...  
Keyword(s):  
Septic Shock ◽  
T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 ◽  
Vol 16 (4) ◽  
pp. 176-181 ◽  
Author(s):  
Christophe Pannetier ◽  
Jos Even ◽  
Philippe Kourilsky
Keyword(s):  
T Cell ◽  
Clinical Samples ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

scholarly journals Dacarbazine Treatment before Peptide Vaccination Enlarges T-Cell Repertoire Diversity of Melan-A–Specific, Tumor-Reactive CTL in Melanoma Patients

2010 ◽  
Vol 70 (18) ◽  
pp. 7084-7092 ◽  
Author(s):  
Belinda Palermo ◽  
Duilia Del Bello ◽  
Alessandra Sottini ◽  
Federico Serana ◽  
Claudia Ghidini ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Peptide Vaccination ◽  
Cell Repertoire ◽  
Specific Tumor ◽  
Repertoire Diversity ◽  
Melanoma Patients
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