scholarly journals CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells

2016 ◽  
Vol 197 (4) ◽  
pp. 1471-1476 ◽  
Author(s):  
Qianqian Zhang ◽  
Hehua Dai ◽  
Karim M. Yatim ◽  
Khodor Abou-Daya ◽  
Amanda L. Williams ◽  
...  
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
Antigen Presentation ◽  
Pancreatic Islet ◽  
Effector T Cell ◽  
T Cell Migration ◽  
Donor Graft ◽  
Cognate Antigen

scholarly journals Regulatory T Cells from Colon Cancer Patients Inhibit Effector T-cell Migration through an Adenosine-Dependent Mechanism

2016 ◽  
Vol 4 (3) ◽  
pp. 183-193 ◽  
Author(s):  
Patrik Sundström ◽  
Hanna Stenstad ◽  
Veronica Langenes ◽  
Filip Ahlmanner ◽  
Lisa Theander ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cells ◽  
Cell Migration ◽  
T Cell ◽  
Regulatory T Cells ◽  
Cancer Patients ◽  
Effector T Cell ◽  
T Cell Migration ◽  
Dependent Mechanism

scholarly journals Cognate antigen directs CD8+ T cell migration to vascularized transplants

2013 ◽  
Vol 123 (6) ◽  
pp. 2663-2671 ◽  
Author(s):  
Jeffrey M. Walch ◽  
Qiang Zeng ◽  
Qi Li ◽  
Martin H. Oberbarnscheidt ◽  
Rosemary A. Hoffman ◽  
...  
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Migration ◽  
Cognate Antigen

scholarly journals Selective Regulation of CD8 Effector T Cell Migration by the p110γ Isoform of Phosphatidylinositol 3-Kinase

2008 ◽  
Vol 180 (4) ◽  
pp. 2081-2088 ◽  
Author(s):  
Amanda L. Martin ◽  
Matthew D. Schwartz ◽  
Stephen C. Jameson ◽  
Yoji Shimizu
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
Phosphatidylinositol 3 Kinase ◽  
Effector T Cell ◽  
T Cell Migration ◽  
Phosphatidylinositol 3

scholarly journals Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection

2018 ◽  
Vol 29 (6) ◽  
pp. 1596-1600 ◽  
Author(s):  
Andrew D. Hughes ◽  
Fadi G. Lakkis ◽  
Martin H. Oberbarnscheidt
Keyword(s):  
T Cell ◽  
Transplant Rejection ◽  
Three Dimensional ◽  
Histocompatibility Antigens ◽  
Renal Allografts ◽  
Effector T Cell ◽  
T Cell Migration ◽  
Dynamic Events ◽  
Peritubular Capillaries ◽  
Cognate Antigen

Kidney transplantation is the treatment of choice for ESRD but is complicated by the response of the recipient’s immune system to nonself histocompatibility antigens on the graft, resulting in rejection. Multiphoton intravital microscopy, referred to as four-dimensional imaging because it records dynamic events in three-dimensional tissue volumes, has emerged as a powerful tool to study immunologic processes in living animals. Here, we will review advances in understanding the complex mechanisms of T cell–mediated rejection made possible by four-dimensional imaging of mouse renal allografts. We will summarize recent data showing that activated (effector) T cell migration to the graft is driven by cognate antigen presented by dendritic cells that surround and penetrate peritubular capillaries, and that T cell–dendritic cell interactions persist in the graft over time, maintaining the immune response in the tissue.

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