scholarly journals Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells

2016 ◽  
Vol 197 (6) ◽  
pp. 2069-2078 ◽  
Author(s):  
A-Jin Lee ◽  
MyungJa Ro ◽  
Jae-Hong Kim
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Mast Cells ◽  
Leukotriene B4 ◽  
Vascular Endothelial ◽  
Leukotriene B4 Receptor ◽  
Endothelial Growth Factor

scholarly journals Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation

2019 ◽  
Vol 20 (12) ◽  
pp. 2897 ◽  
Author(s):  
Sun-Young Kwon ◽  
Jae-Hong Kim
Keyword(s):  
Mast Cells ◽  
Airway Inflammation ◽  
Allergic Inflammation ◽  
Allergic Airway Inflammation ◽  
Leukotriene B4 ◽  
Vascular Endothelial ◽  
Effector Cells ◽  
Elevated Expression ◽  
Leukotriene B4 Receptor ◽  
Endothelial Growth Factor

Mast cells are effector cells in the immune system that play an important role in the allergic airway inflammation. Recently, it was reported that BLT2, a low-affinity leukotriene (LT) B4 receptor, plays a pivotal role in the pathogenesis of allergic airway inflammation through its action in mast cells. We observed that highly elevated expression levels of BLT2 are critical for the pathogenesis leading to allergic airway inflammation, and that if BLT2 expression is downregulated by siBLT2-mediated knockdown, allergic inflammation is dramatically alleviated. Furthermore, we demonstrated that BLT2 mediates the synthesis of vascular endothelial growth factor (VEGF) and Th2 cytokines, such as interleukin (IL)-13, in mast cells during allergic inflammation. Based on the critical roles of BLT2 in mast cells in allergic inflammation, anti-BLT2 strategies could contribute to the development of new therapies for allergic airway inflammation.

scholarly journals Vascular Endothelial Growth Factor–Secreting Mast Cells and Myofibroblasts

2010 ◽  
Vol 30 (6) ◽  
pp. 1220-1227 ◽  
Author(s):  
Suvi Syväranta ◽  
Satu Helske ◽  
Mika Laine ◽  
Jani Lappalainen ◽  
Markku Kupari ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Mast Cells ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Vascular Endothelial Growth Factor (VEGF), Mast Cells and Inflammation

2013 ◽  
Vol 26 (2) ◽  
pp. 327-335 ◽  
Author(s):  
Y.B. Shaik-Dasthagirisaheb ◽  
G. Varvara ◽  
G. Murmura ◽  
A. Saggini ◽  
G. Potalivo ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Mast Cells ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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