scholarly journals LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling

2016 ◽  
Vol 196 (6) ◽  
pp. 2799-2808 ◽  
Author(s):  
Guoku Hu ◽  
Ai-Yu Gong ◽  
Yang Wang ◽  
Shibin Ma ◽  
Xiqiang Chen ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Gene Transcription ◽  
Inflammatory Gene

scholarly journals CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes

2008 ◽  
Vol 28 (12) ◽  
pp. 3894-3904 ◽  
Author(s):  
Brandi A. Thompson ◽  
Véronique Tremblay ◽  
Grace Lin ◽  
Daniel A. Bochar
Keyword(s):  
Gene Expression ◽  
Rna Interference ◽  
Chromatin Remodeling ◽  
Gene Transcription ◽  
Chromatin Structure ◽  
Target Genes ◽  
Promoter Regions ◽  
Hairpin Rna ◽  
Short Hairpin ◽  
Targeted Gene Expression

ABSTRACT ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. Here we report that full-length CHD8 interacts directly with β-catenin and that CHD8 is also recruited specifically to the promoter regions of several β-catenin-responsive genes. Our results indicate that CHD8 negatively regulates β-catenin-targeted gene expression, since short hairpin RNA against CHD8 results in the activation of several β-catenin target genes. This regulation is also conserved through evolution; RNA interference against kismet, the apparent Drosophila ortholog of CHD8, results in a similar activation of β-catenin target genes. We also report the first demonstration of chromatin remodeling activity for a member of the CHD6-9 family of proteins, suggesting that CHD8 functions in transcription through the ATP-dependent modulation of chromatin structure.

Therapeutic modulation of inflammatory gene transcription by kinase inhibitors

2002 ◽  
Vol 2 (6) ◽  
pp. 621-632 ◽  
Author(s):  
Yoshi Satoh ◽  
John K Westwick ◽  
Klaus Schwamborn ◽  
Gordon Alton
Keyword(s):  
Gene Transcription ◽  
Kinase Inhibitors ◽  
Inflammatory Gene

Inflammatory gene transcription in human astrocytes exposed to hypoxia: roles of the nuclear factor-κB and autocrine stimulation

2001 ◽  
Vol 119 (2) ◽  
pp. 365-376 ◽  
Author(s):  
Danica Stanimirovic ◽  
Wandong Zhang ◽  
Clare Howlett ◽  
Pierre Lemieux ◽  
Catherine Smith
Keyword(s):  
Gene Transcription ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Inflammatory Gene ◽  
Human Astrocytes ◽  
Autocrine Stimulation

scholarly journals High-throughput DNA analysis shows the importance of methylation in the control of immune inflammatory gene transcription in chronic periodontitis

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Ana Paula De Souza ◽  
Aline Cristiane Planello ◽  
Marcelo Rocha Marques ◽  
Daniel Diniz De Carvalho ◽  
Sergio Roberto Peres Line
Keyword(s):  
Gene Transcription ◽  
High Throughput ◽  
Chronic Periodontitis ◽  
Dna Analysis ◽  
Inflammatory Gene

scholarly journals BET Inhibition AttenuatesHelicobacter pylori–Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation

2016 ◽  
Vol 196 (10) ◽  
pp. 4132-4142 ◽  
Author(s):  
Jinjing Chen ◽  
Zhen Wang ◽  
Xiangming Hu ◽  
Ruichuan Chen ◽  
Judith Romero-Gallo ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Gene Transcription ◽  
Inflammatory Gene

scholarly journals Cooperation between the INO80 Complex and Histone Chaperones Determines Adaptation of Stress Gene Transcription in the Yeast Saccharomyces cerevisiae

2009 ◽  
Vol 29 (18) ◽  
pp. 4994-5007 ◽  
Author(s):  
Eva Klopf ◽  
Ludmila Paskova ◽  
Carme Solé ◽  
Gloria Mas ◽  
Andriy Petryshyn ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Gene Transcription ◽  
Acute Stress ◽  
Histone Chaperones ◽  
Yeast Saccharomyces Cerevisiae ◽  
Direct Function ◽  
Stress Genes ◽  
Active Transcription ◽  
Stress Gene ◽  
Dependent Mechanism

ABSTRACT In yeast, environmental stresses provoke sudden and dramatic increases in gene expression at stress-inducible loci. Stress gene transcription is accompanied by the transient eviction of histones from the promoter and the transcribed regions of these genes. We found that mutants defective in subunits of the INO80 complex, as well as in several histone chaperone systems, exhibit extended expression windows that can be correlated with a distinct delay in histone redeposition during adaptation. Surprisingly, Ino80 became associated with the ORFs of stress genes in a stress-specific way, suggesting a direct function in the repression during adaptation. This recruitment required elongation by RNA polymerase (Pol) II but none of the histone modifications that are usually associated with active transcription, such as H3 K4/K36 methylation. A mutant lacking the Asf1-associated H3K56 acetyltransferase Rtt109 or Asf1 itself also showed enhanced stress-induced transcript levels. Genetic data, however, suggest that Asf1 and Rtt109 function in parallel with INO80 to restore histone homeostasis, whereas Spt6 seems to have a function that overlaps that of the chromatin remodeler. Thus, chromatin remodeling by INO80 in cooperation with Spt6 determines the shape of the expression profile under acute stress conditions, possibly by an elongation-dependent mechanism.

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