scholarly journals Enhanced Cytotoxic CD8 T Cell Priming Using Dendritic Cell–Expressing Human Papillomavirus-16 E6/E7-p16INK4Fusion Protein with Sequenced Anti–Programmed Death-1

2016 ◽  
Vol 196 (6) ◽  
pp. 2870-2878 ◽  
Author(s):  
Tatiana M. Garcia-Bates ◽  
Eun Kim ◽  
Fernando Concha-Benavente ◽  
Sumita Trivedi ◽  
Robbie B. Mailliard ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Cell ◽  
Dendritic Cell ◽  
Cd8 T Cell ◽  
Human Papillomavirus 16 ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
T Cell Priming

scholarly journals Programmed Death-1 Shapes Memory Phenotype CD8 T Cell Subsets in a Cell-Intrinsic Manner

2013 ◽  
Vol 190 (12) ◽  
pp. 6104-6114 ◽  
Author(s):  
Joanna J. Charlton ◽  
Ioannis Chatzidakis ◽  
Debbie Tsoukatou ◽  
Dimitrios T. Boumpas ◽  
George A. Garinis ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Memory Phenotype ◽  
Programmed Death ◽  
A Cell ◽  
Programmed Death 1

scholarly journals Peripheral and Local Human Papillomavirus 16–Specific CD8 + T-Cell Expansions Characterize Erosive Oral Lichen Planus

2015 ◽  
Vol 135 (2) ◽  
pp. 418-424 ◽  
Author(s):  
Manuelle Viguier ◽  
Hervé Bachelez ◽  
Béatrice Poirier ◽  
Jérémy Kagan ◽  
Maxime Battistella ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
T Cell ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Cd8 T Cell ◽  
Human Papillomavirus 16 ◽  
Oral Lichen

scholarly journals Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

Cell Reports ◽  
2015 ◽  
Vol 13 (2) ◽  
pp. 399-411 ◽  
Author(s):  
Jan Dudeck ◽  
Shanawaz Mohammed Ghouse ◽  
Christian H.K. Lehmann ◽  
Anja Hoppe ◽  
Nadja Schubert ◽  
...  
Keyword(s):  
Mast Cell ◽  
T Cell ◽  
Dendritic Cell ◽  
Cd8 T Cell ◽  
T Cell Priming ◽  
Cell Functionality

scholarly journals Dendritic Cell-Secreted Lipocalin2 Induces CD8+ T-Cell Apoptosis, Contributes to T-Cell Priming and Leads to a TH1 Phenotype

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e101881 ◽  
Author(s):  
Melanie Floderer ◽  
Michaela Prchal-Murphy ◽  
Caterina Vizzardelli
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Apoptosis ◽  
Cd8 T Cell ◽  
T Cell Apoptosis ◽  
T Cell Priming

Intraoperative flurbiprofen alters the expression of PD-1, a molecule of immune checkpoint pathway, in patients undergoing elective thoracoscope resection of lung cancer: a randomized controlled trial

2018 ◽  
Author(s):  
Jicheng Hu ◽  
Xiaoqing Chai ◽  
Di Wang ◽  
Shuhua Shu ◽  
Costan Magnussen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Linear Mixed Model ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Control Group ◽  
Long Term Outcome ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
T1 And T2

Abstract Background: This study aimed to determine the influence of intraoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) flurbiprofen on postoperative level of programmed death 1 (PD-1) in patients undergoing thoracoscope surgery. Methods: In this prospective double-blind trial, patients were randomized to receive intralipid (Control group, n=34, 0.1ml/kg, i.v.) or flurbiprofen axetil (Flurbiprofen group, n=34, 1mg/kg, i.v.) before the induction of anesthesia and 6 hours after the initial injection. PD-1 level on T-cell subsets, inflammation and immune markers in peripheral blood were examined before induction of anesthesia (T0), and after surgery (24 hours (T1), 72 hours (T2) and 1 week (T3)). A linear mixed model was used to examine whether the changes from baseline values (T0) between groups were different during our study. Results: The increases in the percentages of PD-1(+)CD8(+) T-cell observed at T1 and T2 in the control group were higher than in the flurbiprofen group (T1:12.91%±1.65% versus 7.86%±5.71%, P=0.031; T2:11.54%±1.54% versus 8.75%±1.73%, P=0.004) while no difference was observed at T1 and T2 between the groups in terms of change in percentages of PD-1(+)CD4(+) T-cell. Moreover, extensive changes in the percentages of lymphocytes subsets and the concentrations of inflammatory markers was observed at T1 and T2 after surgery, and flurbiprofen seemed to attenuate the most of changes. Conclusion: Perioperative administration of flurbiprofen attenuated postoperative PD-1 increase on CD8(+) T-cell up to 72 hours, but not after this time. The clinical relevance of changes with PD-1 to long-term outcome of surgery is still unknown. Trial registration: Chinese Clinical Trail Registry, ChiCTR-IPR-15006482 (date of registration June 2015) Keywords: Immune cells; Lung cancer; Flurbiprofen; Programmed death 1.

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