scholarly journals Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression

2015 ◽  
Vol 195 (4) ◽  
pp. 1489-1497 ◽  
Author(s):  
Andrew Jones ◽  
Adeleye Opejin ◽  
Jacob G. Henderson ◽  
Cindy Gross ◽  
Rajan Jain ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Induced Tolerance

T.88. Induced Tolerance to Liver Allografts Involves Apoptosis and the Generation of Regulatory T Cells

2009 ◽  
Vol 131 ◽  
pp. S76
Author(s):  
Masato Fujiki ◽  
Samuel Strober ◽  
Olivia Martinez ◽  
Carlos Esquivel ◽  
Sheri Krams
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Induced Tolerance

Human CD4+ regulatory T cells and activation-induced tolerance

2005 ◽  
Vol 7 (7-8) ◽  
pp. 1023-1032 ◽  
Author(s):  
Ehud Hauben ◽  
Maria Grazia Roncarolo
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Induced Tolerance

CD25+ regulatory T cells transfer n-3 long chain polyunsaturated fatty acids-induced tolerance in mice allergic to cow's milk protein

Allergy ◽  
2013 ◽  
Vol 68 (12) ◽  
pp. 1562-1570 ◽  
Author(s):  
L. W. J. van den Elsen ◽  
L. A. P. M. Meulenbroek ◽  
B. C. A. M. van Esch ◽  
G. A. Hofman ◽  
L. Boon ◽  
...  
Keyword(s):  
Fatty Acids ◽  
T Cells ◽  
Regulatory T Cells ◽  
Polyunsaturated Fatty Acids ◽  
Milk Protein ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Protein ◽  
Induced Tolerance ◽  
Long Chain

scholarly journals Prevention of UV radiation–induced immunosuppression by IL-12 is dependent on DNA repair

2005 ◽  
Vol 201 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Agatha Schwarz ◽  
Akira Maeda ◽  
Kerstin Kernebeck ◽  
Harry van Steeg ◽  
Stefan Beissert ◽  
...  
Keyword(s):  
T Cells ◽  
Dna Repair ◽  
Regulatory T Cells ◽  
Uv Radiation ◽  
Contact Hypersensitivity ◽  
Immune Restoration ◽  
Radiation Induced ◽  
Induced Tolerance ◽  
Deficient Mice ◽  
Solar Ultraviolet

The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to induce deoxyribonucleic acid (DNA) repair. UV-induced DNA damage is an important molecular trigger for UV-mediated immunosuppression. Thus, we initiated studies into immune restoration by IL-12 to discern whether its effects are linked to DNA repair. IL-12 prevented both UV-induced suppression of the induction of contact hypersensitivity and the depletion of Langerhans cells, the primary APC of the skin, in wild-type but not in DNA repair-deficient mice. IL-12 did not prevent the development of UV-induced regulatory T cells in DNA repair-deficient mice. In contrast, IL-12 was able to break established UV-induced tolerance and inhibited the activity of regulatory T cells independent of DNA repair. These data identify a new mechanism by which IL-12 can restore immune responses and also demonstrate a link between DNA repair and the prevention of UV-induced immunosuppression by IL-12.

Regulatory T cells in thymic epithelium-induced tolerance. I. Suppression of mature peripheral non-tolerant T cells

1995 ◽  
Vol 25 (9) ◽  
pp. 2563-2571 ◽  
Author(s):  
Yves Modigliani ◽  
Pablo Pereira ◽  
VÉRonique Thomas-Vaslin ◽  
Josselyne Salaün ◽  
Odile Burlen-Defranoux ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Thymic Epithelium ◽  
Induced Tolerance

scholarly journals Important Role for FcγRIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3+ Regulatory T Cells

2013 ◽  
Vol 191 (8) ◽  
pp. 4412-4422 ◽  
Author(s):  
Jia-Bin Sun ◽  
Zou Xiang ◽  
Kenneth G. C. Smith ◽  
Jan Holmgren
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
B Lymphocytes ◽  
Induced Tolerance
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