scholarly journals The Forgotten: Identification and Functional Characterization of MHC Class II Molecules H2-Eb2 and RT1-Db2

2016 ◽  
Vol 196 (3) ◽  
pp. 988-999 ◽  
Author(s):  
Elisa Monzón-Casanova ◽  
Ronald Rudolf ◽  
Lisa Starick ◽  
Ingrid Müller ◽  
Christian Söllner ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Functional Characterization ◽  
Class Ii ◽  
Mhc Class Ii Molecules

scholarly journals Synaptic Clusters of MHC Class II Molecules Induced on DCs by Adhesion Molecule–mediated Initial T-Cell Scanning

2005 ◽  
Vol 16 (7) ◽  
pp. 3314-3322 ◽  
Author(s):  
Hortensia de la Fuente ◽  
María Mittelbrunn ◽  
Lorena Sánchez-Martín ◽  
Miguel Vicente-Manzanares ◽  
Amalia Lamana ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Regulatory Pathway ◽  
Immune Synapse ◽  
Mhc Ii ◽  
Cytoskeleton Reorganization ◽  
Adhesive Contacts ◽  
Enhance Antigen Presentation ◽  
Mhc Class Ii Molecules

Initial adhesive contacts between T lymphocytes and dendritic cells (DCs) facilitate recognition of peptide-MHC complexes by the TCR. In this report, we studied the dynamic behavior of adhesion and Ag receptors on DCs during initial contacts with T-cells. Adhesion molecules LFA-1- and ICAM-1,3-GFP as well as MHC class II-GFP molecules were very rapidly concentrated at the DC contact area. Binding of ICAM-3, and ICAM-1 to a lesser extent, to LFA-1 expressed by mature but not immature DC, induced MHC-II clustering into the immune synapse. Also, ICAM-3 binding to DC induced the activation of the Vav1-Rac1 axis, a regulatory pathway involved in actin cytoskeleton reorganization, which was essential for MHC-II clustering on DCs. Our results support a model in which ICAM-mediated MHC-II clustering on DC constitutes a priming mechanism to enhance antigen presentation to T-cells.

Characterization of bovine MHC class II DRB3 diversity in South American Holstein cattle populations

2015 ◽  
Vol 86 (6) ◽  
pp. 419-430 ◽  
Author(s):  
S.-N. Takeshima ◽  
G. Giovambattista ◽  
N. Okimoto ◽  
Y. Matsumoto ◽  
A. Rogberg-Muñoz ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Holstein Cattle ◽  
South American

scholarly journals Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques

2011 ◽  
Vol 63 (9) ◽  
pp. 611-618 ◽  
Author(s):  
Hannah M. Creager ◽  
Ericka A. Becker ◽  
Kelly K. Sandman ◽  
Julie A. Karl ◽  
Simon M. Lank ◽  
...  
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Full Length ◽  
Cynomolgus Macaques
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