scholarly journals Cutting Edge: Resident Memory CD8 T Cells Occupy Frontline Niches in Secondary Lymphoid Organs

2014 ◽  
Vol 192 (7) ◽  
pp. 2961-2964 ◽  
Author(s):  
Jason M. Schenkel ◽  
Kathryn A. Fraser ◽  
David Masopust
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Lymphoid Organs ◽  
Cutting Edge ◽  
Memory Cd8 T Cells ◽  
Secondary Lymphoid Organs

scholarly journals IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

2012 ◽  
Vol 72 (14) ◽  
pp. 3570-3581 ◽  
Author(s):  
Jan Emmerich ◽  
John B. Mumm ◽  
Ivan H. Chan ◽  
Drake LaFace ◽  
Hoa Truong ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
De Novo ◽  
Lymphoid Organs ◽  
Secondary Lymphoid Organs

scholarly journals Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs

2015 ◽  
Vol 195 (8) ◽  
pp. 3520-3524 ◽  
Author(s):  
Elizabeth L. Frost ◽  
Anna E. Kersh ◽  
Brian D. Evavold ◽  
Aron E. Lukacher
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cutting Edge ◽  
Memory Cd8 T Cells ◽  
High Affinity

scholarly journals Cutting Edge: IL-15–Independent Maintenance of Mucosally Generated Memory CD8 T Cells

2011 ◽  
Vol 186 (12) ◽  
pp. 6667-6671 ◽  
Author(s):  
Katherine C. Verbist ◽  
Mary B. Field ◽  
Kimberly D. Klonowski
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cutting Edge ◽  
Memory Cd8 T Cells

scholarly journals Cutting Edge: Immediate RANTES Secretion by Resting Memory CD8 T Cells Following Antigenic Stimulation

2003 ◽  
Vol 170 (4) ◽  
pp. 1615-1619 ◽  
Author(s):  
Thierry Walzer ◽  
Antoine Marçais ◽  
Frédéric Saltel ◽  
Chantal Bella ◽  
Pierre Jurdic ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cutting Edge ◽  
Antigenic Stimulation ◽  
Memory Cd8 T Cells

scholarly journals Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs

2016 ◽  
Vol 12 (8) ◽  
pp. e1005799 ◽  
Author(s):  
Heng Giap Woon ◽  
Asolina Braun ◽  
Jane Li ◽  
Corey Smith ◽  
Jarem Edwards ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Lymphoid Organs ◽  
Memory Cd8 T Cells ◽  
Specific Tissue

The Lymphoid Chemokine CCL21 Enhances the Migration- and CTL-Inducing Functions of Dendritic Cells

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 1127-1127
Author(s):  
Cheol Yi Hong ◽  
Pawel Kalinski ◽  
Hyeoung-Joon Kim ◽  
Je-Jung Lee
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd8 T Cells ◽  
Conflicts Of Interest ◽  
Cytotoxic T Cells ◽  
Lymphoid Organ ◽  
Lymphoid Organs ◽  
Dependent Manner ◽  
Migratory Capacity ◽  
Secondary Lymphoid Organs

Abstract Abstract 1127 The migration of dendritic cells (DCs) to secondary lymphoid organs is very important to elicit an adaptive immune response in cancer immunotherapy. Here, we show the effect of lymphoid cytokine on the ability of maturing DCs to migrate in response to the lymph node-associated chemokines. The secondary-lymphoid organ chemokine (SLC/CCL21) during DC maturation dramatically enhanced DC migratory capacity responding to CCL21 and CCL19, and, moreover, produced strongly enhanced cytotoxic T cells, although it did not affect the expression of cell surface markers such as CD80, CD83, CD86, and CCR7 and the production of cytokines such as IL-12p70, IL-10, and IL-23. Mature DCs (mDCs) exposed by chemokine produced higher levels of CXCL10 (IP-10) that is one of the chemokines involved in Th1 attraction, but did not affect the production of Th2-attracting cytokine CCL22, compared with unstimulated mDCs. CCL21-exposed DCs induced strongly enhanced numbers of the interferon-g (IFN-g)-expressing antigen-specific CD8+ T cells against tumor-specific antigens in an CXCL10-dependent manner. Cytotoxic CD8+ T cells stimulated with CCL21-exposed DCs expressed higher level of IFN-g than those stimulated with control mDCs. Interestingly, generation of cytotoxic T cells (CTLs) stimulated by TNFa/IL-1b/IL-6/PGE2-treated DCs (sDCs) supplemented with IP-10 produced strong cytotoxic T cells expressing higher level of IFN-g. Tetramer assay showed that CCL21-treated DCs enhanced generation of antigen-specific CTLs. Taken together, our data suggest that mDCs pre-stimulated by chemokine CCL21 enhanced migratory capacity to secondary lymphoid organs and produced strong cytotoxic T cells via IP-10 signaling pathway. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Cutting Edge: Distinct Roles for T Help and CD40/CD40 Ligand in Regulating Differentiation of Proliferation-Competent Memory CD8+ T Cells

2004 ◽  
Vol 173 (4) ◽  
pp. 2217-2221 ◽  
Author(s):  
Martin F. Bachmann ◽  
Katrin Schwarz ◽  
Petra Wolint ◽  
Edwin Meijerink ◽  
Stephen Martin ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cd40 Ligand ◽  
Cutting Edge ◽  
Memory Cd8 T Cells
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