scholarly journals B Cell Differentiation Is Associated with Reprogramming the CCCTC Binding Factor–Dependent Chromatin Architecture of the Murine MHC Class II Locus

2014 ◽  
Vol 192 (8) ◽  
pp. 3925-3935 ◽  
Author(s):  
Parimal Majumder ◽  
Christopher D. Scharer ◽  
Nancy M. Choi ◽  
Jeremy M. Boss
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
B Cell Differentiation ◽  
Chromatin Architecture ◽  
Binding Factor

scholarly journals ZBTB32Is an Early Repressor of the CIITA and MHC Class II Gene Expression during B Cell Differentiation to Plasma Cells

2012 ◽  
Vol 189 (5) ◽  
pp. 2393-2403 ◽  
Author(s):  
Hye Suk Yoon ◽  
Christopher D. Scharer ◽  
Parimal Majumder ◽  
Carl W. Davis ◽  
Royce Butler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Differentiation ◽  
B Cell ◽  
Mhc Class Ii ◽  
Plasma Cells ◽  
Class Ii ◽  
B Cell Differentiation

scholarly journals Dedicator of cytokinesis protein 2 couples with lymphoid enhancer–binding factor 1 to regulate expression of CD21 and B-cell differentiation

2019 ◽  
Vol 144 (5) ◽  
pp. 1377-1390.e4 ◽  
Author(s):  
Yukai Jing ◽  
Danqing Kang ◽  
Luyao Liu ◽  
Huang Huang ◽  
Anwei Chen ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
B Cell Differentiation ◽  
Binding Factor

scholarly journals Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells

1997 ◽  
Vol 5 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Suzanne Lombard-Platet ◽  
Valerie Meyer ◽  
Rhodri Ceredig
Keyword(s):  
B Cells ◽  
B Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Invariant Chain ◽  
B Cell Differentiation ◽  
Cell Clones ◽  
Ifn Γ ◽  
B Lymphoid ◽  
Mhc Class Ii Molecules

Pro-B cells are early B-cell progenitors that retain macrophage potential. We have studied MHC class II molecules and invariant chain inducibility on four class II negative mouse pro- B-cell clones. We analyzed the effects of IL-4 and IFN-γ, which represent the major inducers of class II in the B-lymphoid and monocytic/macrophage lineages, respectively. After 48 h of treatment with either cytokine, three pro-B-cell clones (C2.13, A1.5, and F2.2) expressed intracellular invariant chain and cell-surface class II molecules. One clone (D2.1) remained negative. As already reported, more differentiated 70Z/3 pre-B cells were inducible by IL-4 only. These data suggest that the induction of class II and invariant-chain genes are subject to regulation throughout B-cell differentiation.

scholarly journals Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge.

1990 ◽  
Vol 171 (6) ◽  
pp. 2153-2158 ◽  
Author(s):  
J R Tumang ◽  
D N Posnett ◽  
B C Cole ◽  
M K Crow ◽  
S M Friedman
Keyword(s):  
B Cells ◽  
B Cell ◽  
Mhc Class Ii ◽  
Cell Activation ◽  
Cell Interaction ◽  
Class Ii ◽  
B Cell Differentiation ◽  
Th Cells ◽  
Human B Cells ◽  
Th Cell

Experimentally induced murine graft-vs.-host disease may be characterized by hypergammaglobulinemia, autoantibody formation, and immune complex-mediated organ system damage that mimics SLE. These autoimmune phenomena are mediated by abnormal Th-B cell cooperation, across MHC disparities, in which donor-derived allospecific Th cells recognize and interact with MHC class II antigens on the surface of recipient B cells. Microbial toxins, termed superantigens, which bind to MHC class II molecules and activate selected T cells based on TCR variable gene usage, may induce a similar form of Th-B cell interaction. In the present study, we generated and characterized human Th cell lines reactive with the Mycoplasma arthritidis superantigen (MAM). The essential observation is that resting human B cells bind MAM and present it to superantigen-reactive autologous or allogeneic Th cells, resulting in both Th cell activation and a consequent polyclonal Ig response by the superantigen-bearing B cells.

Lupus Regulator Peptide P140 Represses B Cell Differentiation by Reducing HLA Class II Molecule Overexpression

2018 ◽  
Vol 70 (7) ◽  
pp. 1077-1088 ◽  
Author(s):  
Maud Wilhelm ◽  
Fengjuan Wang ◽  
Nicolas Schall ◽  
Jean-François Kleinmann ◽  
Michael Faludi ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
Class Ii ◽  
Hla Class Ii ◽  
B Cell Differentiation

scholarly journals Germinal Center B Cells Regulate Their Capability to Present Antigen by Modulation of HLA-DO

2002 ◽  
Vol 195 (8) ◽  
pp. 1063-1069 ◽  
Author(s):  
Kim S. Glazier ◽  
Sandra B. Hake ◽  
Helen M. Tobin ◽  
Amy Chadburn ◽  
Elaine J. Schattner ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cells ◽  
B Cell ◽  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Germinal Center ◽  
B Cell Differentiation ◽  
Protein Levels ◽  
Peptide Exchange ◽  
Antigen Presenting

Peptide acquisition by MHC class II molecules is catalyzed by HLA-DM (DM). In B cells, HLA-DO (DO) inhibits or modifies the peptide exchange activity of DM. We show here that DO protein levels are modulated during B cell differentiation. Remarkably, germinal center (GC) B cells, which have low levels of DO relative to naive and memory B cells, are shown to have enhanced antigen presentation capabilities. DM protein levels also were somewhat reduced in GC B cells; however, the ratio of DM to DO in GC B cells was substantially increased, resulting in more free DM in GC B cells. We conclude that modulation of DM and DO in distinct stages of B cell differentiation represents a mechanism by which B cells regulate their capacity to function as antigen-presenting cells. Efficient antigen presentation in GC B cells would promote GC B cell–T cell interactions that are essential for B cells to survive positive selection in the GC.

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